A Study in Diphtheria with Special Reference to Opsonins

This present work embodies the results of clinical observations and laboratory investigations and was undertaken with a view to studying the development of the immunity in diptheria. This particular infection was chosen for the subject of study because it has proved a fruitful source of productive reseach in the past; our knowledge of this disease is perhaps more complete than that of any other infection; and clinical material is always readily available for study

Transmission and Reflection of Bose-Einstein Condensates Incident on a Gaussian Potential Barrier

We investigate how Bose-Einstein condensates, whose initial state is either irrotational or contains a single vortex, scatter off a one-dimensional Gaussian potential barrier. We find that for low atom densities the vortex structure within the condensate is maintained during scattering, whereas at medium and high densities, multiple additional vortices can be created by the scattering process, resulting in complex dynamics and disruption of the atom cloud. This disruption originates from two different mechanisms associated respectively with the initial rotation of the atom cloud and the interference between the incident and reflected matter waves. We investigate how the reflection probability depends on the vorticity of the initial state and on the incident velocity of the Bose-Einstein condensate. To interpret our results, we derive a general analytical expression for the reflection coefficient of a rotating Bose-Einstein condensate that scatters off a spatially-varying one-dimensional potential.Comment: 9 pages, 9 figure

Anomalous quantum reflection of Bose-Einstein condensates from a silicon surface: the role of dynamical excitations

We investigate the effect of inter-atomic interactions on the quantum-mechanical reflection of Bose-Einstein condensates from regions of rapid potential variation. The reflection process depends critically on the density and incident velocity of the condensate. For low densities and high velocities, the atom cloud has almost the same form before and after reflection. Conversely, at high densities and low velocities, the reflection process generates solitons and vortex rings that fragment the condensate. We show that this fragmentation can explain the anomalously low reflection probabilities recently measured for low-velocity condensates incident on a silicon surface.Comment: 5 figures, 5 pages, references correcte

Evidence for Lysosomal Enzymes in Acanthamoeba and Their Activity Changes During Encystment

Author Institution: Graduate Program in Zoology and Department of Microbiology, The Ohio State UniversityAssays on cell-free homogenates of Acanthamoeba castellanii reveal that the three hydrolases, acid phosphatase (APase), acid deoxyribonuclease, and acid ribonuclease (RNase), possess pH optima of 5.0, 4.8, and 5.2, respectively. These enzymes exhibit an enhanced sedimentation at 20,000 x g when sucrose is in the homogenizing buffer. Treatment of homogenates with Triton X-100 increases total enzyme activity. These results suggest that the enzymes are particle-bound in lysosomes. During encystment there is a differential decrease in the activity per cell of all three enzymes, with RNase decreasing most rapidly and APase least rapidly. The specific activity of APase increases during encystment even though its activity per cell gradually decreases

Physiological Responses to Acute Silver Exposure in the Freshwater Crayfish (\u3cem\u3eCambarus diogenes diogenes\u3c/em\u3e)—A Model Invertebrate?

Adult crayfish (Cambarus diogenes diogenes) exposed to 8.41 ± 0.17 μg silver/L (19.4% as Ag+) in moderately hard freshwater under flow-through conditions for 96 h exhibited ionoregulatory disturbance, elevated metabolic ammonia (Tamm) production and substantial silver accumulation in the gills, hemolymph, and hepatopancreas. The ionoregulatory disturbance included both a generally reduced unidirectional Na1 influx and an increased unidirectional Na+ efflux, leading to a substantial net loss of Na+ from the silver-exposed crayfish. The Na+ uptake in silver-exposed crayfish differed overall from controls, while the increased Na+ efflux recovered to control values 48 h into the 96 h of exposure. The general inhibition of Na+ uptake could be explained by a reduced sodium/potassium-adenosine triphosphatase (Na/K-ATPase) activity in terminally obtained gill samples from the silver exposed crayfish. The silver-induced effect on Na+ uptake and loss translated to reduced hemolymph Na+ concentrations but not significantly reduced hemolymph Cl- concentrations. Hemolymph Tamm and Tamm efflux both increased in silver-exposed crayfish, indicating an increased metabolic Tamm production. The present study demonstrates that the toxic mechanism of waterborne silver exposure in freshwater crayfish resembles that of freshwater teleost fish. The crayfish might therefore be a useful model system for extending current environmental regulatory strategies, currently based on teleost fish, to invertebrates

The Association Between the Coach-Athlete Relationship and Burnout Among High School Coaches

Burnout is a term that continues to raise considerable concern among high school coaches and administrators (Raedeke, 1997) and has shown to have negative effects on coaches and athletes alike (Price & Weiss, 2000; Vealey, Armstrong, & Comar, 1998). While burnout has shown to have significant adverse effects, few studies have examined how the coach-athlete relationship may affect a coach s level of perceived burnout. This study sought to understand if the coach-athlete relationship predicted coach burnout. High school coaches (69 males, 62 females) completed the Coach-Athlete Relationship Questionnaire (CART-Q; Jowett & Ntoumanis, 2004), the Coaching Burnout Questionnaire, a modified version of the Athlete Burnout Questionnaire (ABO; Raedeke & Smith. 2001), as well as demographic and background assessments. Results of a multivariate multiple regression indicated that coaches who perceived themselves as committed and had complementary goals with their athletes, showed significantly lower levels o f burnout on all three dimensions. Results indicate that coaches should strive to ensure that they have goals that align with their athletes ’goals and develop a sustained and committed relationship with their players

Chemistry in isolation: High CCH/HCO+ line ratio in the AMIGA galaxy CIG 638

Multi-molecule observations towards an increasing variety of galaxies have been showing that the relative molecular abundances are affected by the type of activity. However, these studies are biased towards bright active galaxies, which are typically in interaction. We study the molecular composition of one of the most isolated galaxies in the local Universe where the physical and chemical properties of their molecular clouds have been determined by intrinsic mechanisms. We present 3 mm broad band observations of the galaxy CIG 638, extracted from the AMIGA sample of isolated galaxies. The emission of the J=1-0 transitions of CCH, HCN, HCO+, and HNC are detected. Integrated intensity ratios between these line are compared with similar observations from the literature towards active galaxies including starburst galaxies (SB), active galactic nuclei (AGN), luminous infrared galaxies (LIRG), and GMCs in M33. A significantly high ratio of CCH with respect to HCN, HCO+, and HNC is found towards CIG 638 when compared with all other galaxies where these species have been detected. This points to either an overabundance of CCH or to a relative lack of dense molecular gas as supported by the low HCN/CO ratio, or both. The data suggest that the CIG 638 is naturally a less perturbed galaxy where a lower fraction of dense molecular gas, as well as a more even distribution could explain the measured ratios. In this scenario the dense gas tracers would be naturally dimmer, while the UV enhanced CCH, would be overproduced in a less shielded medium.Comment: Letter accepted for publication in A&

A disk census for the nearest group of young stars: Mid-infrared observations of the TW Hydrae Association

A group of young, active stars in the vicinity of TW Hydrae has recently been identified as a possible physical association with a common origin. Given its proximity ($\sim$50 pc), age ($\sim$10 Myr) and abundance of binary systems, the TW Hya Association is ideally suited to studies of diversity and evolution of circumstellar disks. Here we present mid-infrared observations of 15 candidate members of the group, 11 of which have no previous flux measurements at wavelengths longer than 2$\mu$m. We report the discovery of a possible 10$\mu$m excess in CD -33$^{\circ}$7795, which may be due to a circumstellar disk or a faint, as yet undetected binary companion. Of the other stars, only TW Hya, HD 98800, Hen 3-600A, and HR 4796A -- all of which were detected by IRAS -- show excess thermal emission. Our 10$\mu$m flux measurements for the remaining members of the Association are consistent with photospheric emission, allowing us to rule out dusty inner disks. In light of these findings, we discuss the origin and age of the TW Hya Association as well as implications for disk evolution timescales.Comment: 10 pages and 1 PostScript figure, accepted for publication in The Astrophysical Journal Letter