Map of Kewaunee County, Wisconsin.

"Copyrighted 1895 by Rooney & Schleis.""E.P. Knoll & Co., Map Publishers, 8 North Sixth St., Phila., Pa.""Entered according to act of Congress in the year 1890 by Brice and Smith in the office of Librarian of Congress."LC Land ownership maps, 1426Includes business directory, population statistical table, list of county officers, views of public, and commercial properties.LC copy imperfect: Mounted on cloth backing, original sheets sectioned into 4 panels to enable folding. DLCLC copy hand colored and mounted on linen. DL

Cardiovascular and Metabolic Responses to Water Aerobics Exercise in Middle-Aged and Older Adults.

Color poster with text, images, and tables describing research conducted by Amy L. Nikolai, Brittany A. Novotny, Cortney L. Bohnen, and Kathryn M. Schleis, advised by Lance C. Dalleck.The purpose of this study was(a)to assess the cardiovascular and metabolic responses to water aerobic exercise and(b)to determine if water aerobics exercise meets the American College of Sports Medicine (ACSM) guidelines for improving and maintaining cardiorespiratory fitness.University of Wisconsin--Eau Claire Office of Research and Sponsored Programs

Clinical features and prognosis of Type 2 Myocardial Infarction in acutely decompensated diabetic patients

BACKGROUND: After the introduction of the universal definition of myocardial infarction, the incidence and diagnosis of type 2 myocardial infarction have risen dramatically, yet there are no clear guidelines on clinical management. Diabetic patients are at high risk for developing type 2 myocardial infarction when admitted in a decompensated state, and they are also at high risk for future cardiovascular events. METHODS: We performed a retrospective analysis of 1058 patients admitted with diabetic ketoacidosis or hyperosmolar hyperglycemic state between 2011 and 2016. Patients were included if they had cardiac troponin I measured within 24 hours of admission, were older than 18 years of age, and had no evidence of acute coronary syndrome on admission. Baseline characteristics, admission laboratory test results, major adverse cardiovascular events, cardiac stress testing, and coronary angiography data up to 1 year after admission were reviewed. Patients were categorized into 2 groups: those with and those without type 2 myocardial infarction. The study had 2 endpoints: mortality and major adverse cardiac events (MACE) at 1 year and an abnormal result on stress test or coronary angiography at 1 year. RESULTS: Of the 845 patients who met the inclusion criteria, 133 patients (15%) had type 2 myocardial infarction on admission. Patients with type 2 myocardial infarction were at a significantly higher risk for mortality and MACE at 1 year than those without. Patients with type 2 myocardial infarction were also at higher risk for developing an abnormal result on stress test or coronary angiography within 1 year of admission as compared with those without type 2 myocardial infarction (40% vs 24%; odds ratio 2; P = .0699). CONCLUSION: Acutely decompensated diabetic patients with type 2 myocardial infarction are at increased risk for death and MACE. These patients may also be at risk for undiagnosed coronary artery disease

Resistance of canine lymphoma cells to adenoviral infection due to reduced cell surface RGD binding integrins

Recombinant adenovirus vectors (Ad) have been recognized as effective in vivo gene delivery vehicles and utilized as gene therapy agents for a number of cancers. The elucidation of viral entry mechanisms has allowed the development of recombinant vectors that exploit existing cell surface receptors to achieve entry into the cell. B lymphocytes are normally resistant to infection by adenovirus 5, likely due to the lack of the Coxsackie and Adenovirus receptor (CAR). Using reverse-transcriptase PCR and flow cytometry, the CD40 receptor has been shown to be expressed on many lymphoma cells. We exploited this finding to develop a gene therapy strategy for treatment of canine B-cell lymphoma. Ad5 was targeted to cells expressing CD40 via CD40 ligand (CD40L) and was effective in infecting CD40-expressing control cells; however, both primary canine lymphoma cells and cell lines demonstrated limited evidence of transduction. Following receptor binding, adenovirus entry into cells may require interaction with αvβ3/5 integrins; we demonstrate that canine lymphoma cells are deficient in these integrins. Reduced αvβ3 integrin expression may render these cells incapable of internalizing Ad vectors. Thus, any viral targeting approaches for treatment of canine lymphoma must also take into account the potential lack of internalization signals