Asthma in changing environments - chances and challenges of international research collaborations between South America and Europe - study protocol and description of the data acquisition of a case-control-study

<p>Abstract</p> <p>Background</p> <p>Asthma in children is an emerging public health problem in South America. So far, research in this part of the world is limited. This paper presents the methodology and description of the data acquisition of an asthma case-control study conducted in the Central South of Chile.</p> <p>Methods/Design</p> <p>A hospital-based case-control study about asthma (188 cases, 294 controls) in children (6-15 years) was carried out in Valdivia, Chile between November 2008 and December 2009. Data on asthma risk factors were collected by computer-assisted personal interview using validated questions from e.g. ISAAC phase II. Data on household dust exposure (endotoxin, allergen analyses), skin prick tests to most common allergens, stool examinations for parasitic infection, and blood samples (total IgE, genetics) were collected. Additionally, 492 randomly chosen blood donors were recruited in order to assess allele frequencies in the population of Valdivia.</p> <p>Discussion</p> <p>Overall 1,173 participants were contacted. Response was 82% among cases and 65% among controls. Atopic sensitization was high (78% among cases, 47% among controls). Cases had a statistically significantly (p < .0001) increased self-reported 12-month prevalence of symptoms of rhinitis (82% vs. 51%) and wheeze (68% vs. 16%). The study is well placed to address current hypotheses about asthma and its correlates in the South American context. Results of this study might help develop novel, innovative and individualized prevention strategies in countries in transition with respect to the South American context.</p

Morphogrammata / The lettered Art of Optatian. Figuring Cultural Transformations in the Age of Constantine

This volume explores one of the most complex, multifaceted and momentous of all western cultural transformations: the refashioning of the Roman principate under the emperor Constantine in the early fourth century AD. It does so through the kaleidoscopic lens of one of antiquity’s most fascinating (and maligned) artists, Publilius Optatianus Porfyrius. Optatian’s experiments with word and image are little known among classicists. But, as contributors to this volume argue, his ‘morphogrammatic’ creations uniquely reflect, figure and shape the cultural dynamics of the fourth century. This is the first edited book dedicated to Optatian’s picture-poems and their various historical contexts. By bringing together different disciplinary perspectives (including ancient history, classical philology, art history, theology, philosophy and media studies), the volume demonstrates how Optatian gave form to the various political, intellectual and cultural currents of his age. At the same time, contributors champion Optatian as a uniquely creative artist – and one who anticipated some of our most pressing literary critical, art historical and philosophical concerns today