Estimation of capital and operation costs of backhoe loaders

Accurate estimation of equipment costs is a key factor in feasibility study and evaluation of design alternatives of mining projects. In this paper, capital and operation costs of backhoe loaders are estimated using multiple linear regression (MLR), based on principle component analysis (PCA). These cost functions are consisted of five independent variables; bucket size, digging depth, dump height, weight and horse power. The MLR is conducted in two steps. At the first correlation between independent variables is omitted using PCA technique. Thereafter, MLR functions are established using selected significant PCs and total cost functions are constituted as functions of initial variables. At the end, accuracy of functions are evaluated using mean absolute error rate method

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

Increasing concern about age-related diseases, particularly musculoskeletal injuries and orthopedic conditions, highlights the need for strategies such as tissue engineering to address them. Surface modification has been developed to create pro-healing interfaces, personalize scaffolds and provide novel medicines. Polydopamine, a mussel-inspired adhesive polymer with highly reactive functional groups that adhere to nearly all substrates, has gained attention in surface modification strategies for biomaterials. Polydopamine was primarily developed to modify surfaces, but its effectiveness has opened up promising approaches for further applications in bioengineering as carriers and nanoparticles. This review focuses on the recent discoveries of the role of polydopamine as a surface coating material, with focus on the properties that make it suitable for tackling musculoskeletal disorders. We report the evolution of using it in research, and discuss papers involving the progress of this field. The current research on the role of polydopamine in bone, cartilage, muscle, nerve, and tendon regeneration is discussed, thus giving comprehensive overview about the function of polydopamine both in-vitro and in-vivo. Finally, the report concludes presenting the critical challenges that must be addressed for the clinical translation of this biomaterial while exploring future perspectives and research opportunities in this area

Hybrid method for selection of the optimal process of leachate treatment in waste treatment and valorization plants or landfills

“The final publication is available at Springer via http://dx.doi.org/10.1007/s10098-014-0834-4”Leachate from waste landfill or treatment plants is a very complex and highly contaminated liquid effluent. In its composition, it is found dissolved organic matter, inorganic salts, heavy metals, and other xenobiotic organic compounds, so it can be toxic, carcinogenic, and capable of inducing a potential risk to biota and humans. European law does not allow such leachate to leave the premises without being depolluted. There are many procedures that enable debugging, always combining different techniques. Choosing the best method to use in each case is a complex decision, as it depends on many tangible and intangible factors that must be weighed to achieve a balance between technical, cost, and environmental sustainability. 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Application of TOPSIS method for selecting the most appropriate blast design

Blasting operation should be performed satisfying some criteria, such as fragmentation, flyrock, and cost. To reach the most appropriate alternative among previous performed blast designs, all the criteria should be simultaneously considered in the analysis. To do so, rather new emerging approaches such as Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), a branch of multi-criteria decision-making techniques could be applied. Using TOPSIS method, the present study tries to investigate the blasting operation in the Tajareh limestone mine and select the most appropriate blasting pattern. According to the obtained results, alternative ten with hole diameter of 64 mm and staggered pattern designed by Ash formula, was selected to be the best decision. Application of this alternative comparatively satisfies both fragmentation and flyrock