Gene discovery and genome editing to develop cisgenic crops with improved resistance against pathogen infection

Includes French abstractThe review discusses disease resistance in plants, the improvement of crop plants through genome editing to produce cisgenic cultivars, technologies available for gene discovery, novel mechanisms of resistance, and related regulatory issues. The new cultivars developed from these techniques are broadly grouped as: (i) cisgenic crops, where a gene from a sexually compatible species is replaced or introduced; and (ii) transgenic crops, where a gene from a sexually incompatible plant is replaced or introduced. Precise replacement of non-functional genes (r) with functional R genes using genome editing tools, similar to backcross breeding, can significantly improve resistance in commercial crops