An Empirical Analysis of Clinical Legal Education in Middle Age

Modern clinical legal education has turned fifty. Much has been written on its development and history, both as a pedagogy and in relation to the broader enterprise of legal education. But there has been no longitudinal empirical analysis documenting that growth until now. By looking at a series of nationwide surveys starting in 2007 and comparing those results to surveys dating back to the 1970s, this article paints a factual picture of clinical legal education’s progression from early adulthood to middle age

The 2019-20 Survey of Applied Legal Education

This report presents the results of the 2019-20 Center for the Study of Applied Legal Education (CSALE) Survey of Applied Legal Education. The survey was composed of two parts – a Master Survey directed to ABA accredited U.S. law schools and a Sub-Survey distributed to each person teaching in a law clinic or field placement course. Ninety-five percent of law schools and over 1,300 clinical teachers participated in the survey. The results provide valuable insight into clinical programs and law clinic and field placement courses in areas such as design, capacity, administration, funding, and pedagogy, and into the role and status of clinical educators in the legal academy. This is CSALE\u27s fifth triennial survey, following up on surveys in 2007-08, 2010-11, 2013-14, and 2016-17

Comment on: ‘‘The dark nature of Somma-Vesuvius volcano:Evidence from the 3.5 ka BP Avellino eruption’’ by Milia A.Raspini A., Torrente M.M.,

We present here some criticism to the scientific content of the paper of Milia et al. [2007. The dark nature of Somma-Vesuvius volcano: evidence from the 3.5 ka B.P. Avellino eruption. Quaternary International, 173–174, 57–66] published in Quaternary International. Milia et al. (2007) interpreted seismic lines in the Gulf of Naples (southern Italy), and inferred the presence of deposits from a large debris avalanche which occurred just before the Avellino eruption of Somma-Vesuvius volcano. The authors supported their seismic profile interpretation with on-land stratigraphies and logs. However, we present here different on-land data that demonstrate the inconsistency of the occurrence of any debris avalanche before or after the Avellino eruption, and we provide also an alternative interpretation for the observed seismic facies offshore of Somma-Vesuvius

The 2016-17 Survey of Applied Legal Education

This report summarizes the results of the Center for the Study of Applied Legal Education’s (CSALE) 2016-17 Survey of Applied Legal Education. The 2016-17 Survey was CSALE’s fourth triennial survey of law clinic and field placement (i.e., externship) courses and educators. The results provide insight into the state of applied legal education in areas like program design, capacity, administration, funding, and pedagogy, and the role of applied legal education and educators in the legal academy. Law schools, legal educators, scholars, and oversight agencies rely on CSALE’s data. They do so with the summary results provided here, the earlier Reports on CSALE’s 2007-08, 2010-11 and 2013-14 Surveys, and through hundreds of customized reports cross-tabulating various aspects of the data that CSALE has provided to schools, scholars, and legal educators.

Volcaniclastic debris flow occurrences in the Campania region (southern Italy) and their relation to Holocene - late Pleistocene pyroclastic fall deposits: implications for large scale hazard mapping

The Campania Region (Southern Italy) is characterized by the frequent occurrence of volcaniclastic debris flows that produce damage to property and loss of life (more than 170 deaths between 1996 and 1999). Historical investigation allowed the identification of more than 500 events during the last four centuries; in particular, more than half of these occurred in the last 100 years, causing hundreds of deaths. The aim of this paper is to identify debris flow proneness and to quantify hazard. To this end, we compared several elements such as the thickness distribution of pyroclastic fall deposits from the last 18 ka of the Vesuvius and Phlegrean Fields volcanoes, the slopes of relieves, and the historical record of volcaniclastic debris flows from AD 1500 to the present. Results show that flow occurrence is not only a function of the cumulative thickness of past pyroclastic fall deposits but also depends on the age of emplacement. Deposits younger than 10 ka (Holocene eruptions) apparently increase the risk of debris flows, while those older than 10 ka (Late Pleistocene eruptions) seem to play a less prominent role. This is probably in relation to different climatic conditions, and therefore different rates of erosion of pyroclastic falls between the Holocene and the Late Pleistocene. Based on the above considerations, we compiled a large-scale debris flow hazard map of the study area in which five main hazard zones are identified: very low, low, moderate, high and very high

Assessing pyroclastic fall hazard through field data and numerical simulation: Example from Vesuvius

A general methodology of pyroclastic fall hazard assessment is proposed on the basis of integrated results of field studies and numerical simulations. These approaches result in two different methods of assessing hazard: (1) the ‘‘field frequency,’’ based on the thickness and distribution of past deposits and (2) the ‘‘simulated probability,’’ based on the numerical modeling of tephra transport and fallout. The proposed methodology mostly applies to volcanoes that, by showing a clear correlation between the repose time and the magnitude of the following eruptions, allows the definition of a reference ‘‘maximum expected event’’ (MEE). The application to Vesuvius is shown in detail. Using the field frequency method, stratigraphic data of 24 explosive events in the 3–6 volcanic explosivity index range in the last 18,000 years of activity are extrapolated to a regular grid in order to obtain the frequency of exceedance in the past of a certain threshold value of mass loading (100, 200, 300, and 400 kg/m2). Using the simulated probability method, the mass loading related to the MEE is calculated based on the expected erupted mass (5 1011 kg), the wind velocity profiles recorded during 14 years, and various column heights and grain-size populations. The role of these factors was parametrically studied performing 160,000 simulations, and the probability that mass loading exceeded the chosen threshold at each node was evaluated. As a general rule, the field frequency method results are more reliable in proximal regions, provided that an accurate database of field measurements is available. On the other hand, the simulated probability method better describes events in middle distal areas, provided that the MEE magnitude can be reliably assumed. In the Vesuvius case, the integration of the two methods results in a new fallout hazard map, here presented for a mass loading value of 200 kg/m2

Behaviour of adenylic and pyridinic compounds in gingival tissue after a short-term exposure to air

Biochemical variations of adenine and pyridine compounds in human gingival grafts during the period between excision and implantation have been studied. These groups of compounds are considered as «indicators» of the metabolic and energetic status of the living cells. Adenylic compounds such as ATP, ADP and AMP are involved in numerous metabolic processes as «modulators» of allosteric enzymes.NAD+ and NADP+ are involved in the carbohydrate metabolism as co-factors of many reactions of oxydoreduction. The exposure to air of the gingival tissue induces modifications in the energy state of the cells as well as in the ox-reox system. No variation is detectable in the intermediates of the pyridine compounds cycle.Dans des gencives humaines prélevées pour des greffes, ont été étudiées, à certains intervalles de temps entre le prélèvement et la greffe, les variations biochimiques des composés adényliques et pyridiniques, qui sont les «indicateurs» des conditions énergétiques et métaboliques du tissu. Des composés comme l’ATP, l’ADP et l’AMP participent à de nombreux processus métaboliques comme «modulateurs» des enzymes allostériques. NAD+ et NADP + participent au métabolisme des carbohydrates comme co-facteurs de nombreuses réactions d’oxydoréduction. Une brève exposition de la gencive à l’air provoque des changements dans le métabolisme des cellules et du système d’oxydoréduction. Il n’y a pas de variation notable dans les composés intermédiaires du cycle pyridinique

Tracking and characterization of partial and full epithelial-mesenchymal transition cells in a mouse model of metastatic breast cancer

The various stages of epithelial-mesenchymal transition (EMT) generate phenotypically heterogeneous populations of cells. Here, we detail a dual recombinase lineage tracing system using a transgenic mouse model of metastatic breast cancer to trace and characterize breast cancer cells at different EMT stages. We describe analytical steps to label cancer cells at an early partial or a late full EMT state, followed by tracking their behavior in tumor slice cultures. We then characterize their transcriptome by five-cell RNA sequencing. For complete details on the use and execution of this protocol, please refer to Luond et al. (2021)

The Endocannabinoid System: A Putative Role in Neurodegenerative Diseases

BACKGROUND: Following the characterization of the chemical structure of D9-tetrahydrocannabinol (THC), the main psychoactive constituent of marijuana, researchers have moved on with scientific valuable explorations. OBJECTIVES: The aim of this review is to highlight the role of endocannabinoid system in neurodegenerative diseases. MATERIALS AND METHODS: The article is a critical analysis of the most recent data currently present in scientific literature on the subject; a qualitative synthesis of only the most significant articles has been performed. RESULTS: In central nervous system, endocannabinoids show a neuromodulatory function, often of retrograde type. This way, they play an important role in synaptic plasticity and in cognitive, motor, sensory and affective processes. In addition, in some acute or chronic pathologies of central nervous system, such as neurodegenerative and neuroinflammatory diseases, endocannabinoids can perform a pro-homeostatic and neuroprotective function, through the activation of CB1 and CB2 receptors. Scientific evidence shows that an hypofunction or a dysregulation of the endocannabinoid system may be responsible for some of the symptoms of diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s, Parkinson’s and Alzheimer’s diseases. CONCLUSIONS: The important role played by endocannabinoid system promises interesting developments, in particular to evaluate the effectiveness of new drugs in both psychiatry and neurology