Tacrolimus and diabetic ketoacidosis after kidney transplantation in a 15-year-old girl (Case Report)

Tacrolimus is a main drug for induction and maintenance immunosuppression for patients with kidney transplants in many centers. One of important side effect of drug is post-transplant diabetes mellitus. Of course, diabetes ketoacidosis (DKA) is rare. In this report, a 12-year-old girl with DKA was presented after 45 days of kidney transplantation

Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy

Background and Aim: Core needle biopsy (CNB) is less invasive and has fewer side effects compared to surgical procedures, and provides accurate information about the nature of the tumor. The aim of this study was to evaluate the efficacy of CNB in the diagnosis of the cause of lymphadenopathy. Materials and Methods: In this study, 153 patients with lymphadenopathy underwent CNB from 2014 to 2018. Immunohistochemistry staining with appropriate markers was performed. Excisional biopsy, clinical and radiological data were evaluated using spss-21 softwere, data were analyzed by one way ANOVA and tukey test (p<0/05). Results: Diffuse large B-cell lymphoma was more frequent (41%). Histopathological diagnosis of core needle biopsy was correct in 83.23% of the patients,among them 11.11% were confirmed by excisional biopsy and 88.88% by clinical and radiological findings. There was a significant relationship between the mean age of the patients and location of lymphadenopathy (P = 0.02) and also between the mean age and pathology diagnosis (P<0.001). The accuracy, sensitivity, and positive predictive value of CNB were 90%, 100%, and 90%, respectively. Conclusion: Diagnosis of the cause of lymphadenopathy by CNB was correct in most cases and its diagnostic efficacy was confirmed. The present results recommend CNB as a suitable method without side effects for investigation of the cause of lymphadenopathy