BCS theory of nodal superconductors

This course has a dual purpose. First we review the successes of the weak-coupling BCS theory in describing new classes of superconductors discovered since 1979. They include the heavy-fermion superconductors, high-Tc cuprate superconductors, organic superconductors, Sr2RuO4, etc. Second, we present the quasiclassical approximation introduced by Volovik, which we extend to describe the thermodynamics and the thermal conductivity of the vortex state in nodal superconductors. This approach provides the most powerful tool to identify the symmetry of the energy gap function Delta(k) in these new superconductors.Comment: 31 pages, 33 figure

The Need for Compliance Verification in Collaborative Business Processes

Compliance constrains processes to adhere to rules, standards, laws and regulations. Non-compliance subjects enterprises to litigation and financial fines. Collaborative business processes cross organizational and regional borders implying that internal and cross regional regulations must be complied with. To protect customs’ data, European enterprises must comply with the EU data privacy regulation (general data protection regulation - GDPR) and each member state’s data protection laws. An example of non-compliance with GDPR is Facebook, it is accused for breaching subscriber trust. Compliance verification is thus essential to deploy and implement collaborative business process systems. It ensures that processes are checked for conformance to compliance requirements throughout their life cycle. In this paper we take a proactive approach aiming to discuss the need for design time preventative compliance verification as opposed to after effect runtime detective approach. We use a real-world case to show how compliance needs to be analyzed and show the benefits of applying compliance check at the process design stag

The Need for Compliance Verification in Collaborative Business Processes

Compliance constrains processes to adhere to rules, standards, laws and regulations. Non-compliance subjects enterprises to litigation and financial fines. Collaborative business processes cross organizational and regional borders implying that internal and cross regional regulations must be complied with. To protect customs’ data, European enterprises must comply with the EU data privacy regulation (general data protection regulation - GDPR) and each member state’s data protection laws. An example of non-compliance with GDPR is Facebook, it is accused for breaching subscriber trust. Compliance verification is thus essential to deploy and implement collaborative business process systems. It ensures that processes are checked for conformance to compliance requirements throughout their life cycle. In this paper we take a proactive approach aiming to discuss the need for design time preventative compliance verification as opposed to after effect runtime detective approach. We use a real-world case to show how compliance needs to be analyzed and show the benefits of applying compliance check at the process design stag

Brain monoamine oxidase A activity predicts trait aggression

The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Therefore, a common polymorphism in the MAO A gene (MAOA, Mendelian Inheritance in Men database number 309850, referred to as high or low based on transcription in non-neuronal cells) has been investigated in a number of externalizing behavioral and clinical phenotypes. These studies provide evidence linking the low MAOA genotype and violent behavior but only through interaction with severe environmental stressors during childhood. Here, we hypothesized that in healthy adult males the gene product of MAO A in the brain, rather than the gene per se, would be associated with regulating the concentration of brain amines involved in trait aggression. Brain MAO A activity was measured in vivo in healthy nonsmoking men with positron emission tomography using a radioligand specific for MAO A (clorgyline labeled with carbon 11). Trait aggression was measured with the multidimensional personality questionnaire (MPQ). Here we report for the first time that brain MAO A correlates inversely with the MPQ trait measure of aggression (but not with other personality traits) such that the lower the MAO A activity in cortical and subcortical brain regions, the higher the self-reported aggression (in both MAOA genotype groups) contributing to more than one-third of the variability. Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression

Aligning Monitoring and Compliance Requirements in Evolving Business Networks

Dynamic business networks (BNs) are intrinsically characterised by change. Compliance requirements management, in this context, may become particularly challenging. Partners in the network may join and leave the collaboration dynamically and tasks over which compliance requirements are specified may be consequently delegated to new partners or backsourced by network participants. This paper considers the issue of aligning the compliance requirements in a BN with the monitoring requirements they induce on the BN participants when change (or evolution) occurs. We first provide a conceptual model of BNs and their compliance requirements, introducing the concept of monitoring capabilities induced by compliance requirements. Then, we present a set of mechanisms to ensure consistency between the monitoring and compliance requirements when BNs evolve, e.g. tasks are delegated or backsourced in-house. Eventually, we discuss a prototype implementation of our framework, which also implements a set of metrics to check the status of a BN in respect of compliance monitorability

Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design s

ABSTRACT A refined model of the colchicine site on tubulin was used to design an improved analog of the pyrrole parent compound, JG-03-14. The optimized compound, NT-7-16, was evaluated in biological assays that confirm that it has potent activities as a new colchicine site microtubule depolymerizer. NT-7-16 exhibits antiproliferative and cytotoxic activities against multiple cancer cell lines, with IC 50 values of 10-16 nM, and it is able to overcome drug resistance mediated by the expression of P-glycoprotein and the bIII isotype of tubulin. NT-7-16 initiated the concentration-dependent loss of cellular microtubules and caused the formation of abnormal mitotic spindles, leading to mitotic accumulation. The direct interaction of NT-7-16 with purified tubulin was confirmed, and it was more potent than combretastatin A-4 in these assays. Binding studies verified that NT-7-16 binds to tubulin within the colchicine site. The antitumor effects of NT-7-16 were evaluated in an MDA-MB-435 xenograft model and it had excellent activity at concentrations that were not toxic. A second compound, NT-9-21, which contains dichloro moieties in place of the 3,5-dibromo substituents of NT-7-16, had a poorer fit within the colchicine site as predicted by modeling and the Hydropathic INTeractions score. Biological evaluations showed that NT-9-21 has 10-fold lower potency than NT-7-16, confirming the modeling predictions. These studies highlight the value of the refined colchicine-site model and identify a new pyrrole-based colchicine-site agent with potent in vitro activities and promising in vivo antitumor actions

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a common dietary component that has histone deacetylase inhibition activity and exciting potential in cancer prevention. The mechanisms by which SFN imparts its chemopreventive properties are of considerable interest and little is known of its preventive potential for breast cancer. expression facilitated the induction of cellular apoptosis in human breast cancer cells.Collectively, our results provide novel insights into SFN-mediated epigenetic down-regulation of telomerase in breast cancer prevention and may open new avenues for approaches to SFN-mediated cancer prevention

Gene by Disease Interaction on Orbitofrontal Gray Matter in Cocaine Addiction

Chronic cocaine use has been associated with structural deficits in brain regions having dopamine receptive neurons. However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability. We therefore examined variations in gray matter volume (GMV) as a function of lifetime drug use and the monoamine oxidase A (MAOA) genotype in cocaine use disorders (CUD) and healthy controls