111 research outputs found
A Study of a Carbonaceous Gold Ore
The presence of graphite in the ore of the Missouri-McKee Mine has made its treatment by the methods now used quite unsatisfactory. The study was undertaken to deÂvelop a new flow sheet which would give a high recovery and yet be economical enough to handle low grade material
The amalgamated duplication of a ring along a multiplicative-canonical ideal
After recalling briefly the main properties of the amalgamated duplication of
a ring along an ideal , denoted by R\JoinI, we restrict our attention
to the study of the properties of R\JoinI, when is a multiplicative
canonical ideal of \cite{hhp}. In particular, we study when every regular
fractional ideal of is divisorial
SOME ABSTRACT PROPERTIES OF SEMIGROUPS APPEARING IN SUPERCONFORMAL THEORIES
A new type of semigroups which appears while dealing with
superconformal symmetry in superstring theories is considered. The ideal series
having unusual abstract properties is constructed. Various idealisers are
introduced and studied. The ideal quasicharacter is defined. Green's relations
are found and their connection with the ideal quasicharacter is established.Comment: 11 page
Formin homology 2 domains occur in multiple contexts in angiosperms
BACKGROUND: Involvement of conservative molecular modules and cellular mechanisms in the widely diversified processes of eukaryotic cell morphogenesis leads to the intriguing question: how do similar proteins contribute to dissimilar morphogenetic outputs. Formins (FH2 proteins) play a central part in the control of actin organization and dynamics, providing a good example of evolutionarily versatile use of a conserved protein domain in the context of a variety of lineage-specific structural and signalling interactions. RESULTS: In order to identify possible plant-specific sequence features within the FH2 protein family, we performed a detailed analysis of angiosperm formin-related sequences available in public databases, with particular focus on the complete Arabidopsis genome and the nearly finished rice genome sequence. This has led to revision of the current annotation of half of the 22 Arabidopsis formin-related genes. Comparative analysis of the two plant genomes revealed a good conservation of the previously described two subfamilies of plant formins (Class I and Class II), as well as several subfamilies within them that appear to predate the separation of monocot and dicot plants. Moreover, a number of plant Class II formins share an additional conserved domain, related to the protein phosphatase/tensin/auxilin fold. However, considerable inter-species variability sets limits to generalization of any functional conclusions reached on a single species such as Arabidopsis. CONCLUSIONS: The plant-specific domain context of the conserved FH2 domain, as well as plant-specific features of the domain itself, may reflect distinct functional requirements in plant cells. The variability of formin structures found in plants far exceeds that known from both fungi and metazoans, suggesting a possible contribution of FH2 proteins in the evolution of the plant type of multicellularity
Kinesin-5: Cross-Bridging Mechanism to Targeted Clinical Therapy.
Kinesin motor proteins comprise an ATPase superfamily that works hand in hand with microtubules in every eukaryote. The mitotic kinesins, by virtue of their potential therapeutic role in cancerous cells, have been a major focus of research for the past 28. years since the discovery of the canonical Kinesin-1 heavy chain. Perhaps the simplest player in mitotic spindle assembly, Kinesin-5 (also known as Kif11, Eg5, or kinesin spindle protein, KSP) is a plus-end-directed motor localized to interpolar spindle microtubules and to the spindle poles. Comprised of a homotetramer complex, its function primarily is to slide anti-parallel microtubules apart from one another. Based on multi-faceted analyses of this motor from numerous laboratories over the years, we have learned a great deal about the function of this motor at the atomic level for catalysis and as an integrated element of the cytoskeleton. These data have, in turn, informed the function of motile kinesins on the whole, as well as spearheaded integrative models of the mitotic apparatus in particular and regulation of the microtubule cytoskeleton in general. We review what is known about how this nanomotor works, its place inside the cytoskeleton of cells, and its small-molecule inhibitors that provide a toolbox for understanding motor function and for anticancer treatment in the clinic
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