Diseño y construcción Bodytech Centro Comercial Gran Plaza El Ensueño Bogotá

La construcción del nuevo Centro Comercial El Ensueño en la localidad de Ciudad Bolívar, al sur de la ciudad de Bogotá, representa una oportunidad de negocio para la empresa Bodytech, que con el propósito de expansión de la marca en un sector que ha venido creciendo demográficamente. El proyecto presentado en este trabajo de grado abarca la formulación de la oportunidad de negocio, el estudio técnico, estudio financiero y el plan de gestión del proyecto desarrollando las áreas de conocimiento establecidas por la Guía del PMBOK (6 Ed.)The construction of the new El Ensueño Shopping Center in the town of Ciudad Bolívar, south of the city of Bogotá, represents a business opportunity for the Bodytech company, which with the purpose of expanding the brand in a sector that has been growing demographically. The project presented includes the formulation of the business opportunity, the technical study, the financial study, and the project management plan, developing the knowledge areas established by the PMBOK Guide (6 Ed.

Alimentos funcionales: avances de aplicación en agroindustria

Contexto: Se realizó un estudio acerca de los compuestos bioactivos de ciertos alimentos, teniendo en cuenta los beneficios que generan a la salud humana. Método: En este trabajo se presenta una revisión bibliográfica de las diferentes aplicaciones de los alimentos funcionales y su aplicación en la agroindustria. Resultados: Los malos hábitos alimenticios pueden generar un déficit en el requerimiento de compuestos bioactivos importantes para el buen funcionamiento del organismo; a su vez, la demanda y la tendencia de consumo de alimentos funcionales se hace cada vez más grande debido a los múltiples beneficios y usos potenciales que se pueden obtener de éstos, junto con las necesidades nutricionales básicas que se requieren. Conclusiones: Se evidencia el interés por realizar nuevos estudios en la obtención de este tipo de alimentos. Para esto, se deberán incorporar nuevos ingredientes en matrices alimentarias, con el fin de preservar los compuestos bioactivos y que ejecuten su principal función: que aparte de nutrir, reduzcan o controlen diversas enfermedades que en algunos casos pueden ser crónicas

Alimentos funcionales: avances de aplicación en agroindustria

Context: A study was made about the bioactive compounds of certain foods, while taking into account the benefits they generate to human health.Method: This article presents a bibliographic review of the different applications of functional foods and their application in agroindustry.Results: It was found that bad eating habits can generate a deficit in the requirement of bioactive compounds important for the proper functioning of the organism. On the other hand, the demand and the trend of consumption of functional foods is getting bigger due to the multiple benefits and potential uses that can be obtained from them, along with the basic nutritional needs they cover.Conclusions: There is evidence of interest in conducting new studies about obtaining this type of food. For this, new ingredients should be incorporated in food matrices, in order to preserve the bioactive compounds and that they perform their main function (apart from nourish): to reduce or control various diseases that may be chronic in some cases.Contexto: Se realizó un estudio acerca de los compuestos bioactivos de ciertos alimentos, teniendo en cuenta los beneficios que generan a la salud humana.Método: En este trabajo se presenta una revisión bibliográfica de las diferentes aplicaciones de los alimentos funcionales y su aplicación en la agroindustria.Resultados: Los malos hábitos alimenticios pueden generar un déficit en el requerimiento de compuestos bioactivos importantes para el buen funcionamiento del organismo; a su vez, la demanda y la tendencia de consumo de alimentos funcionales se hace cada vez más grande debido a los múltiples beneficios y usos potenciales que se pueden obtener de éstos, junto con las necesidades nutricionales básicas que se requieren.Conclusiones: Se evidencia el interés por realizar nuevos estudios en la obtención de este tipo de alimentos. Para esto, se deberán incorporar nuevos ingredientes en matrices alimentarias, con el fin de preservar los compuestos bioactivos y que ejecuten su principal función: que aparte de nutrir, reduzcan o controlen diversas enfermedades que en algunos casos pueden ser crónicas

Ven, una historia te contaré: Estrategia didáctica que potencia la comunicación en las infancias sordas

Ven, una historia te contaré:Estrategia didáctica quepotencia la comunicaciónen las infancias sorda

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewiring. Here we show that the transcriptional co-activator peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) suppresses prostate cancer progression and metastasis. A metabolic co-regulator data mining analysis unveiled that PGC1α is downregulated in prostate cancer and associated with disease progression. Using genetically engineered mouse models and xenografts, we demonstrated that PGC1α opposes prostate cancer progression and metastasis. Mechanistically, the use of integrative metabolomics and transcriptomics revealed that PGC1α activates an oestrogen-related receptor alpha (ERRα)-dependent transcriptional program to elicit a catabolic state and metastasis suppression. Importantly, a signature based on the PGC1α–ERRα pathway exhibited prognostic potential in prostate cancer, thus uncovering the relevance of monitoring and manipulating this pathway for prostate cancer stratification and treatment

The EU Center of Excellence for Exascale in Solid Earth (ChEESE): Implementation, results, and roadmap for the second phase

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Management of acute diverticulitis with pericolic free gas (ADIFAS). an international multicenter observational study

Background: There are no specific recommendations regarding the optimal management of this group of patients. The World Society of Emergency Surgery suggested a nonoperative strategy with antibiotic therapy, but this was a weak recommendation. This study aims to identify the optimal management of patients with acute diverticulitis (AD) presenting with pericolic free air with or without pericolic fluid. Methods: A multicenter, prospective, international study of patients diagnosed with AD and pericolic-free air with or without pericolic free fluid at a computed tomography (CT) scan between May 2020 and June 2021 was included. Patients were excluded if they had intra-abdominal distant free air, an abscess, generalized peritonitis, or less than a 1-year follow-up. The primary outcome was the rate of failure of nonoperative management within the index admission. Secondary outcomes included the rate of failure of nonoperative management within the first year and risk factors for failure. Results: A total of 810 patients were recruited across 69 European and South American centers; 744 patients (92%) were treated nonoperatively, and 66 (8%) underwent immediate surgery. Baseline characteristics were similar between groups. Hinchey II-IV on diagnostic imaging was the only independent risk factor for surgical intervention during index admission (odds ratios: 12.5, 95% CI: 2.4-64, P =0.003). Among patients treated nonoperatively, at index admission, 697 (94%) patients were discharged without any complications, 35 (4.7%) required emergency surgery, and 12 (1.6%) percutaneous drainage. Free pericolic fluid on CT scan was associated with a higher risk of failure of nonoperative management (odds ratios: 4.9, 95% CI: 1.2-19.9, P =0.023), with 88% of success compared to 96% without free fluid ( P <0.001). The rate of treatment failure with nonoperative management during the first year of follow-up was 16.5%. Conclusion: Patients with AD presenting with pericolic free gas can be successfully managed nonoperatively in the vast majority of cases. Patients with both free pericolic gas and free pericolic fluid on a CT scan are at a higher risk of failing nonoperative management and require closer observation

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI