Adaptive potential assessment of future teachers at the first stage of their professional training

The health-saving component of the educational environment requires improvement in the organization of physical culture and health, medical and preventive, psychological and pedagogical work to overcome maladjustment and develop the models of personal safe behavior from the first steps in the teaching professio

Evaluation of the adaptive potential of first-graders with normal speech development and speech disorders

The objective of our research was to evaluate and compare the results of the study of physical development, somatic health, and adaptive capabilities of younger students with normal speech development and speech disorders during entering the school. The physical development of students was assessed using the somatometric, somatoscopic, and physiometric method

Systematic risk assessment of the formation of the respiratory system pathology in the pressure member of refractory products

The analysis of dust loading in 15 press operators refractories PervouralDinas plant (Sverdlovsk region, Russia), are exposed to harmful production factors (dust, free silica, vibration, industrial noise, physical exertion), were examined at the Yekaterinburg MedicalResearchCenter for Prophylaxis and Health Protection in Industrial Workers for the period 2018-2019.Проведен анализ пылевой нагрузки у 15 прессовщиков огнеупорных изделий Первоуральского динасового завода (Свердловская область, Россия), подвергающихся воздействию вредных производственных факторов (пыли свободного диоксида кремния, вибрации производственного шума, физического перенапряжения), находившихся на обследовании в ФБУН «ЕМНЦ ПОЗРПП»Роспотребнадзора за период 2018-2019 гг

Study of the organization of drinking regime in Yekaterinburg schools

The purpose of the study– assessment of the organization of the drinking regime in the schools of the city of Yekaterinburg.Цель исследования – оценка организации питьевого режима в школах города Екатеринбург

Current status of nuclear cardiology in the Russian Federation

The article is devoted to the analysis of the current status of nuclear cardiology in the Russian Federation. The data on the number of facilities performing radionuclide investigations for the diagnosis and monitoring of the treatment of cardiovascular diseases, their staffing and equipment are given. The statistics of the conducted nuclear cardiology tests for 2018-2020 are given, as well as their methods, features and diagnostic significance are described

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Previously Undescribed Gross HACE1 Deletions as a Cause of Autosomal Recessive Spastic Paraplegia

Spastic paraplegia and psychomotor retardation with or without seizures (SPPRS, OMIM 616756) is a rare genetic disease caused by biallelic pathogenic variants in the HACE1 gene. Originally, these mutations have been reported to be implicated in tumor predisposition. Nonetheless, via whole exome sequencing in 2015, HACE1 mutations were suggested to be the cause of a new autosomal recessive neurodevelopmental disorder, which is characterized by spasticity, muscular hypotonia, and intellectual disability. To date, 14 HACE1 pathogenic variants have been described; these variants have a loss-of-function effect that leads to clinical presentations with variable severities. However, gross deletions in the HACE1 gene have not yet been mentioned as a cause of spastic paraplegia. Here, we report a clinical case involving a 2-year-old male presenting with spasticity, mainly affecting the lower limbs, and developmental delay. Exome sequencing, chromosomal microarray analysis, and mRNA analysis were used to identify the causative gene. We revealed that the clinical findings were due to previously undescribed HACE1 biallelic deletions. We identified the deletion of exon 7: c.(534+1_535-1)_(617+1_618-1)del (NM_020771.4) and the gross deletion in the 6q16.3 locus, which affected the entire HACE1 gene: g.105018931_105337494del, (GRCh37). A comprehensive diagnostic approach for the patients with originally homozygous mutations in HACE1 is required since false homozygosity results are possible. More than 80% of the described mutations were reported to be homozygous. Initial hemizygosity is hard to detect by quantitative methods, and this may challenge molecular diagnostic identification in patients with spastic paraplegia

EFFECTS OF PHOTOHEMOTHERAPY ON THE CLINICAL COURSE OF BRONCHIAL ASTHMA

Background: Anti-inflammatory and immunoregulatory effects of photohemotherapy have been demonstrated in myocarditis, chronic obstructive pulmonary disease, some autoimmune and other disorders. There are only limited reports on the use of photohemotherapy in bronchial asthma (BA). Aim: To assess the influence of blue- and red-light photohemotherapy on clinical course of BA. Materials and methods: 480 hospitalized patients with persistent moderate BA and mild (44.5%) or moderate (55.5%) exacerbation were randomized to receive standard therapy of asthma exacerbation and photohemotherapy (treatment group, n=250) or standard therapy only (control group, n=230). Blue-light photohemotherapy (photodiode apparatus Solaris, n=220) or redlight photohemotherapy (helium-neon gas laser, n=30) was applied according to the schedule: procedure duration – 30 minutes, number of sessions – 5–7, every 2–3 days. Results: In asthma exacerbation, adding photohemotherapy to standard treatment was associated with more rapid improvement of clinical symptoms: maximal total asthma scores were achieved by the day 7–10 in patients with mild exacerbation and by the day 10–14 in patients with moderate exacerbation. Therapeutic effects of blue-light photohemotherapy were superior to those of red-light photohemotherapy. The data of 3-year follow-up supported the role of photohemotherapy in achieving asthma control: in the treatment group, proportion of patients with total control of asthma was 1.3-fold higher and one-year hospitalization number was lower by 34.8% compared with the controls. Conclusion: Blue-light and red-light photohemotherapy positively influences the clinical course of asthma and is associated with faster remission achievement and reduction of duration and frequency of hospitalizations