Effects of Langmuir Kinetics of Two-Lane Totally Asymmetric Exclusion Processes in Protein Traffic

In this paper, we study a two-lane totally asymmetric simple exclusion process (TASEP) coupled with random attachment and detachment of particles (Langmuir kinetics) in both lanes under open boundary conditions. Our model can describe the directed motion of molecular motors, attachment and detachment of motors, and free inter-lane transition of motors between filaments. In this paper, we focus on some finite-size effects of the system because normally the sizes of most real systems are finite and small (e.g., size $\leq 10,000$). A special finite-size effect of the two-lane system has been observed, which is that the density wall moves left first and then move towards the right with the increase of the lane-changing rate. We called it the jumping effect. We find that increasing attachment and detachment rates will weaken the jumping effect. We also confirmed that when the size of the two-lane system is large enough, the jumping effect disappears, and the two-lane system has a similar density profile to a single-lane TASEP coupled with Langmuir kinetics. Increasing lane-changing rates has little effect on density and current after the density reaches maximum. Also, lane-changing rate has no effect on density profiles of a two-lane TASEP coupled with Langmuir kinetics at a large attachment/detachment rate and/or a large system size. Mean-field approximation is presented and it agrees with our Monte Carlo simulations.Comment: 15 pages, 8 figures. To be published in IJMP

FluentEditor: Text-based Speech Editing by Considering Acoustic and Prosody Consistency

Text-based speech editing (TSE) techniques are designed to enable users to edit the output audio by modifying the input text transcript instead of the audio itself. Despite much progress in neural network-based TSE techniques, the current techniques have focused on reducing the difference between the generated speech segment and the reference target in the editing region, ignoring its local and global fluency in the context and original utterance. To maintain the speech fluency, we propose a fluency speech editing model, termed \textit{FluentEditor}, by considering fluency-aware training criterion in the TSE training. Specifically, the \textit{acoustic consistency constraint} aims to smooth the transition between the edited region and its neighboring acoustic segments consistent with the ground truth, while the \textit{prosody consistency constraint} seeks to ensure that the prosody attributes within the edited regions remain consistent with the overall style of the original utterance. The subjective and objective experimental results on VCTK demonstrate that our \textit{FluentEditor} outperforms all advanced baselines in terms of naturalness and fluency. The audio samples and code are available at \url{https://github.com/Ai-S2-Lab/FluentEditor}.Comment: Submitted to ICASSP'202