5 research outputs found
Lanthanum carbonate - A first line phosphate binder?
- Publication venue
- 'Wiley'
- Publication date
- 01/07/2007
- Field of study
Complement Factor H Gene Mutation Associated with Autosomal Recessive Atypical Hemolytic Uremic Syndrome
- Publication venue
- The American Society of Human Genetics. Published by Elsevier Inc.
- Publication date
- 31/05/2000
- Field of study
Genetic studies into inherited and sporadic hemolytic uremic syndrome
- Author
- Anthony Nicholls
- Ault
- Benigni
- Bergstein
- Berns
- Cameron
- Edelsten
- Farr
- Gasser
- Jansen
- Judith A. Goodship
- Kaplan
- Kaplan
- Kuhn
- Lathrop
- Lian
- Meri
- Moake
- Monnens
- Pangburn
- Paul Warwicker
- Peter Turnpenny
- Pichette
- Pirson
- Reid
- Remuzzi
- Remuzzi
- Ripoche
- Robson
- Roodhooft
- Rosemary L. Donne
- Roy M. Ward
- Sharma
- Sim
- Thompson
- Timothy H.J. Goodship
- Truedsson
- Warwicker
- Weiler
- Yves Pirson
- Zipfel
- Publication venue
- 'Wiley'
- Publication date
- 01/01/1998
- Field of study
Hemolytic uremic syndrome (HUS) in adults carries a high morbidity and mortality, and its cause remains unknown despite many theories. Although familial HUS is rare, it affords a unique opportunity to elucidate underlying mechanisms that mw have relevance to acquired HUS. We have undertaken a genetic linkage study based on a candidate gene approach. A common area bounded by the markers D1S212 and D1S306, a distance of 26 cM located at 1q32 segregated with the disease (Z max 3.94). We demonstrate that the gene for factor II lies within the region. Subsequent mutation analysis of the factor II gene has revealed two mutations in patients with HUS. In an individual with the sporadic/ relapsing form of the disease we have found a mutation comprising a deletion, subsequent frame shift and premature stop codon leading to half normal levels of serum factor H. In one of the three families there is a point mutation in exon 20 causing an arginine to glycine change, which is likely to alter structure and hence function of the factor H protein. Factor H is a major plasma protein that plays a critical regulatory role in the alternative pathway of complement activation. In light of these findings and previous reports of HUS in patients with factor H deficiency, we postulate that abnormalities of factor H may be involved in the etiology of HUS
Genetic studies into inherited and sporadic hemolytic uremic syndrome
- Author
- Anthony Nicholls
- Ault
- Benigni
- Bergstein
- Berns
- Cameron
- Edelsten
- Farr
- Gasser
- Jansen
- Judith A. Goodship
- Kaplan
- Kaplan
- Kuhn
- Lathrop
- Lian
- Meri
- Moake
- Monnens
- Pangburn
- Paul Warwicker
- Peter Turnpenny
- Pichette
- Pirson
- Reid
- Remuzzi
- Remuzzi
- Ripoche
- Robson
- Roodhooft
- Rosemary L. Donne
- Roy M. Ward
- Sharma
- Sim
- Thompson
- Timothy H.J. Goodship
- Truedsson
- Warwicker
- Weiler
- Yves Pirson
- Zipfel
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Stratified analyses refine association between TLR7 rare variants and severe COVID-19
- Author
- A. Gulati
- Aaron Butler
- Aayesha Kazi
- Abdelhakim Altabaibeh
- Abdul Kayani
- Abhinav Gupta
- Abigail Crew
- Abigail Knighton
- Abigail Short
- Abigail Taylor
- Abiola Harrison
- Adam Brayne
- Adam Brown
- Adam Loveridge
- Adama Fofano
- Aditya Kuravi
- Adriana Botello
- Adriana Palom
- Agilan Kaliappan
- Agilan Kaliappan
- Agnieszka Kubisz-Pudelko
- Agustín Albillos
- Ahmed Zaki
- Ailbhe Brady
- Ailsa Golightly
- Ailstair Nichol
- Ainhi Mac
- Ajay Raithatha
- Alain Vuylsteke
- Alan Maclean
- Alan Morrison
- Alan Neal
- Alasdair Bamford
- Alasdair Hay
- Alastair McGregor
- Alastair Rose
- Alastair Thomas
- Aled Morgan
- Alessandra Bandera
- Alessio Gerussi
- Alex Howlett
- Alex Lyon
- Alex McCurdy
- Alex Puxty
- Alexander Hoischen
- Alexandra Metcalfe
- Alexandra Williams
- Alexandre C. Pereira
- Alfredo Serrano-Ruiz
- Alice Harvey
- Alice Michael Mitchell
- Alice Nicholson
- Alice Poole
- Alice Thomas
- Alicia A.C. Waite
- Alicia Knight
- Alicia Price
- Alison Brown
- Alison Brown
- Alison Durie
- Alison Ghosh
- Alison Harrison
- Alison Lewis
- Alison Lye
- Alison Quinn
- Alison Turnbull
- Alison Williams
- Alison Wilson
- Alissa Kent
- Alistair Gales
- Alistair Hughes
- Alistair Meikle
- Alistair Nichol
- Alistair Roy
- Allison Daniels
- Alun Rees
- Amanda Ayers
- Amanda Cowton
- Amanda Lyle
- Amanda McGregor
- Amanda Sanderson
- Amanda Tyler
- Amanda Whileman
- Amber Cox
- Amber Ford
- Ambreen Tariq
- Amelia Daniel
- Amelia Stacey
- Ami Wilkinson
- Amie Reddy
- Amit Patel
- Amitaa Maharajh
- Amro Katary
- Amy Bowes
- Amy Clark
- Amy Collins
- Amy Cunningham
- Amy Easthope
- Amy Easthope
- Amy Easthope
- Amy Gardner
- Amy Kirkby
- Amy Pickard
- Amy Shepherd
- Ana Alvaro
- Ana Lisboa
- Ana Luisa Tomas
- Ana Vochin
- Anca Gherman
- Andre Franke
- Andrea Biondi
- Andrea Kay
- Andrea Webster
- Andres Naranjo
- Andrew Burtenshaw
- Andrew Fagan
- Andrew Gratrix
- Andrew Higham
- Andrew Higham
- Andrew Stenhouse
- Andrew Swain
- Andy Campbell
- Andy Drummond
- Andy Law
- Anelise C. Zborowski
- Aneta Bociek
- Anezka Pratley
- Angela Allan
- Angela Andrew
- Angela Lombardi
- Angharad Williams
- Angie Fawkes
- Angiy Michael
- Anil Hormis
- Anila Sukumaran
- Anisha Sukha
- Anita Agasou
- Anita Furlong
- Anna Cavazza
- Anna Joseph
- Anna Morris
- Anna Reed
- Anna Reyes
- Anna Roynon-Reed
- Annalisa Dance
- Anne Carter
- Anne Cowley
- Anne Cowley
- Anne Emma Heron
- Anne Haldeos
- Anne Hayes
- Anne Hudson
- Anne Nicholson
- Anne Nicholson
- Anne Saunderson
- Anne Todd
- Anne Zak
- Annette Hilldrith
- Annette Nilsson
- Anthony Barron
- Anthony Gordon
- Anthony Murphy
- Anthony Ng
- Anthony Rostron
- Anton Mayer
- Antonio Julià
- Aparna George
- Archana Bashyal
- Arianna Bellini
- Arianna Tucci
- Armorel Salberg
- Arnold Dela Rosa
- Arunkumar Ganesan
- Ascanio Tridente
- Ashar Ahmed
- Ashley Kinch
- Ashok Sundar
- Asifa Ali
- Atideb Mitra
- Atul Garg
- Audrey Coutts
- Austin Rattray
- Avril Donaldson
- Axel Schmidt
- Ayaa Eltayeb
- Ayesha Javaid
- Azmerelda Abraheem
- Baird Tracy
- Bally Purewal
- Balvinder Baines
- Barbara Winter-Goodwin
- Barney Scholefield
- Barry Milligan
- Beatriz Nafria
- Becky Lenagh
- Beena David
- Beena Eapen
- Belinda Roberts
- Ben Attwood
- Ben Creagh-Brown
- Ben Donne
- Ben Player
- Benedict Andrew
- Benjamin Shelley
- Benjamin Thomas
- Berina Zametica
- Bernadette Gallagher
- Bernadette King
- Bernard Hadebe
- Bethan Blackledge
- Bethan Blackledge
- Bethan Charles
- Bethan Deacon
- Bethan Deacon
- Bethan Gay
- Bethan Ogg
- Bethan Stowe
- Bethany Gumbrill
- Beverley Faulkner
- Beverley Wadams
- Bijal Patel
- Bijoy Mathew
- Borislava Borislavova
- Brendan Sloan
- Brian Digby
- Brian Johnston
- Brian Wilkinson
- Brice Djeugam
- Bridget Fuller
- Bridget Hopkins
- Bridgett Masunda
- Brigid Hairsine
- Brijesh Patel
- Britt-Sabina Löscher
- Bryan Yates
- Callum Kaye
- Callum Mackay
- Camilla Ledgard
- Carey Tierney
- Carina Cruz
- Carl Murphy
- Carla Pothecary
- Carla Pothecary
- Carlos Castro Delgado
- Carly Price
- Carmel Stuart
- Carole Hays
- Caroline Abernathy
- Caroline Burnett
- Caroline Davis
- Caroline Wrey Brown
- Carrie Demetriou
- Carter David
- Caspar I. van der Made
- Catherine Borra
- Catherine Dennis
- Catherine Dexter
- Catherine Jardine
- Catherine Novis
- Cathrine Basikolo
- Cathy Jones
- Cecilia Ahmed
- Cecilia Peters
- Ceilia Boz
- Celia Harris
- Ceri Battle
- Ceri Lynch
- Champa Jetha
- Chantal McParland
- Charlene Davies
- Charles Hinds
- Charles Piercy
- Charlie Dunmore
- Charlie Vigurs
- Charlotte Coates
- Charlotte Downes
- Charlotte Eckbad
- Charlotte Humphrey
- Charlotte Kamundi
- Charlotte Summers
- Charlotte Summers
- Charlotte Willis
- Charmaine Shovelton
- Chenqing Zheng
- Cheryl Finch
- Cheryl Graham
- Cheryl Marriott
- Chetan Parmar
- Chloe Davison
- Chloe Lyons
- Chloe Rishton
- Chris Marsh
- Chris P. Ponting
- Chris Thorpe
- Christine Almaden-Boyle
- Christine Eastgate-Jackson
- Christine Sicat
- Christopher Fine
- Christopher McParland
- Christopher Thompson
- Christopher Wasson
- Christopher Whitton
- Chrsitopher Woodford
- Chunda Sri-Chandana
- Ciara Collins
- Claire Cheyne
- Claire Fox
- Claire Gorman
- Claire Hewitt
- Claire Jarman
- Claire Jennings
- Claire Marie Beith
- Claire Nolan
- Claire Phillips
- Claire Phillips
- Claire Prendergast
- Clare Bradley
- Clare Buckley
- Clare Finney
- Clare Smedley
- Clare Tibke
- Clare Whyte
- Colene Adams
- Colin Begg
- Colin Begg
- Colin Wells
- Corinne Pawley
- Corrienne McCulloch
- Craig Brandwood
- Craig Brantwood
- Craig Denmade
- Craig Sell
- Cristiana Bianco
- Dabheoc Coleman
- Dan Hawcutt
- Dana Raynard
- Daniel Horner
- Daniel Martin
- Daniel Menzies
- Daniele Cristiano
- Daniele Prati
- Danielle Childs
- Danielle McLaughlan
- Danielle Thornton
- Danielle Walker
- Danny McAuley
- Daphene Clarke
- Dario Salutous
- Dariusz Tetla
- Darsh Potla
- Dave Hope
- Dave Vedage
- David Antcliffe
- David Baptista
- David Brealey
- David Brealey
- David Collier
- David Ellinghaus
- David Foote
- David Golden
- David Helm
- David Loader
- David Maslove
- David O. Hamilton
- David Pogson
- David Shaw
- David Tyl
- David Wright
- Dawn Collier
- Dawn Hales
- Dawn Jones
- Dawn Law
- Dawn Trodd
- Deanna Stephens
- Debbie Branney
- Debbie Hamilton
- Deborah Afolabi
- Deborah Baines
- Deborah Butcher
- Deborah Dawson
- Deborah Melia
- Deborah Smyth
- Deborah Warren
- Deborah White
- Dee Mullan
- Dee Mullan
- Deepak Subramanian
- Deirdre Fottrell-Gould
- Delordson Kallon
- Denise Cosgrove
- Denise Donaldson
- Denise Griffin
- Denise McFarland
- Denise O'Connor
- Denise Skinner
- Denise Skinner
- Denise Webster
- Dewi Williams
- Dhanalakshmi Bakthavatsalam
- Dhaneesha Senaratne
- Dharam Purohit
- Di Wood
- Diane Kelly
- Diane Lomas
- Dina Bell
- Dominic Strachan
- Donna Duffin
- Dorota Banach
- Dorota Burda
- Dorota Potoczna
- Dr Ben Chandler
- Drew Goodchild
- Duncan Kaye
- Eamon Coughlan
- Eamon Raith
- Eamon Raith
- Edna Fernandes Da Gloria
- Edward Combes
- Edward Jude
- Ekaterina Watson
- Ekta Merwaha
- Elaine Brinkworth
- Elaine Heeney
- Elaine Stephenson
- Eleanor Andrews
- Eleanor Corcoran
- Eleanor Moncur
- Eleanor Smith
- Elena Anastasescu
- Elena Apetri
- Elena Maccacari
- Elizabeth Allan
- Elizabeth Goff
- Elizabeth Gordon
- Elizabeth Horsley
- Elizabeth Radford
- Elizabeth Smithson
- Elizabeth Stones
- Elizabeth Timlick
- Elizabeth Wilby
- Ellen Brown
- Ellen Jerome
- Ellen Knights
- Ellie Davies
- Ellie Mcmaster
- Elvezia M. Paraboschi
- Emily Beech
- Emily Bevan
- Emily Johnson
- Emily London
- Emily Peasgood
- Emily Peasgood
- Emma Carter
- Emma Collins
- Emma Dobson
- Emma Dooks
- Emma Fisher
- Emma Gendall
- Emma Goodwin
- Emma Lee
- Emma Low
- Emma McKenna
- Emma Meadows
- Emma Perkins
- Emma Stoddard
- Emma Tagliavini
- Emma Thomas
- Emma Tilney
- Emma Virgilio
- Emma Williams
- Eoghan Meaney
- Erika Salciute
- Eriko Morino
- Erin Collins
- Erin Trumper
- Erola Pairo-Castineira
- Estefania Treus Gude
- Esther Daubney
- Esther Duncan
- Esther Mwaura
- Ethel Black
- Euan Murdoch
- Eva Beranova
- Evie Headlam
- Evita Pappa
- Faith Kibutu
- Farah Nasir
- Fatima Bibi
- Faye Moore
- Felicity Anderson
- Felicity Williams
- Ffyon Davies
- Filip Taneski
- Fiona Auld
- Fiona Barrett
- Fiona Farquhar
- Fiona Griffiths
- Fiona Kelly
- Fiona McNeela
- Fiona Trim
- Fiona Wakinshaw
- Flora Peyvandi
- Fran Hurford
- Francesco Blasi
- Francesco Malvestiti
- Frater Alasdair
- Gabor Debreceni
- Gabriella Lindergard
- Gamu Lubimbi
- Gareth A.L. Jones
- Gareth Hughes
- Gareth Kennard-Holden
- Gary H. Mills
- Gary Semple
- Gayathri Subramanian
- Gayatri Ramakrishnan
- Gemma Castaño-Vinyals
- Gemma Millen
- Gemma Williams
- Gemma Wray
- Geoff Watson
- George Franke
- George Tsinaslanidis
- Georgia Bercades
- Georgia Durrant
- Georgia Efford
- Georgina Randell
- Geraldine Hambrook
- Geraldine Sloane
- Geraldine Ward
- Giacomo Grasselli
- Gill Arbane
- Gillian Andrew
- Gillian Bell
- Gillian Hobden
- Giuseppe Citerio
- Giuseppe Foti
- Gladys Martir
- Glykeria Pakou
- Gordan McCreath
- Gordon Houston
- Grace Padden
- Grainne O'Connor
- Gwenllian Sera Howe
- Gwyneth Davies
- Hafiz Rehman
- Hamza Meghari
- Hannah Ellis
- Hannah Golding
- Hannah Sainsbury
- Hannah Williams
- Hannah-Louise Wood
- Hanning Mal
- Harini Rangarajan
- Harish Venkatesh
- Harriet Kent
- Harriet Noble
- Harriet Pearson
- Hayley Bates
- Hayley Blakemore
- Hayley Middleton
- Heather Biggs
- Heather Button
- Heather Fox
- Heather McGuinness
- Heather Passmore
- Heather Savill
- Heather Weston
- Heather Willis
- Helder Filipe
- Helen Blackman
- Helen Campbell
- Helen Hanson
- Helen Hill
- Helen Holcombe
- Helen Jeffrey
- Helen Langton
- Helen Millward
- Helen Newell
- Helen Quinn
- Helen Szoor-McElhinney
- Helen T-Michael
- Helen Tench
- Helen Thomas
- Helen Tivenan
- Helen Tranter
- Helen Trower
- Helen Wassall
- Helen Whittle
- Helen Wild
- Helena Hanratty
- Helena Prady
- Henrik Reschreiter
- Henry Houlden
- Hollie Bancroft
- Hollie Brooke
- Hollie Curgenven
- Holly Belfield
- Holly Coles
- Hugh Montgomery
- Ian Clement
- Ian Edmond
- Ian Turner-Bone
- Ian White
- Igor Otahal
- Igor Otahal
- Ilaria Beretta
- Imrun Nagra
- India McKenley
- Indra Chadbourn
- Inez Wynter
- Ingeborg D. Welters
- Ingrid Hass
- Inthakab Ali Mohamed Ali
- Iona Burn
- Irene Macharia
- Irene Pinzuti
- Irving Mayangao
- Isheunesu Mapfunde
- Isobel Birkinshaw
- Isobel Sutherland
- Ivone Lancoma-Malcolm
- J. Kenneth Baillie
- J. Kenneth Baillie
- J. Kenneth Baillie
- Jacinta Guerin
- Jack Biddle
- Jack Dalziel
- Jack Easton
- Jackie Green
- Jacqueline Daglish
- Jacqueline McCormick
- Jacqueline Smith
- Jacqueline Thomas
- Jacqui Smith
- Jacyntha Khera
- Jade Bryant
- Jade Cole
- Jade Harris
- Jade Harris
- Jade Liew
- Jaime Carungcong
- Jaime Fernandez-Roman
- James Furniss
- James Hornsby
- James Jones
- James Morgan
- James Rand
- James Scriven
- James Scriven
- James Scriven
- James Watson
- Jamie Matthews
- Jamila Kassam
- Jana Gurasashvili
- Jane Beadle
- Jane Gaylard
- Jane Gaylard
- Jane Gregory
- Jane Hunt
- Jane Ireland
- Jane Martin
- Jane Perez
- Jane Pheby
- Jane Weaver
- Janet Imeson-Wood
- Janet McGowan
- Janet Phipps
- Janet Ryan-Smith
- Janet Sargeant
- Janice Hartley
- Janine Birch
- Janine Mallinson
- Jannik Boos
- Jasmine Egan
- Jasmine Medhora
- Jason Cupitt
- Jason Sowter
- Jaspret Gill
- Javier Fernandez
- Jay Naisbitt
- Jayachandran Radhakrishnan
- Jayaprakash Singh
- Jayne Craig
- Jayne Evitts
- Jayne Willson
- Jean Wilson
- Jeanette Hargreaves
- Jeff Little
- Jen Meikle
- Jen Service
- Jenkins Samuel
- Jennifer Anderson
- Jennifer Philbin
- Jennifer Valentine
- Jennifer Whitbread
- Jenny Birch
- Jenny Ritzema
- Jeremy Bewley
- Jeremy Scanlon
- Jerik Verula
- Jeronimo Moreno-Cuesta
- Jess Caterson
- Jess Perry
- Jessica Jones
- Jessica Pendlebury
- Jessica Reynolds
- Jessica Thrush
- Jesus M. Banales
- Jez Pinnell
- Jiantao Chen
- Jill Greig
- Jisha Mathew
- Jo Dasgin
- Jo Fletcher
- Jo Singleton
- Jo Stickley
- Jo-Anna Conyngham
- Joachim L. Schultze
- Joana Queiroz
- Joana Texeira
- Joann Barker
- Joanna Brown
- Joanna Butler
- Joanna Matheson
- Joanna Wong
- Joanne Bradley-Potts
- Joanne Deery
- Joanne Donnachie
- Joanne Finn
- Joanne Hawes
- Joanne Hutter
- Joanne Ingham
- Joanne Rhodes
- Joanne Riches
- Joanne Riches
- Joanne Rothwell
- Joanne Waldron
- Joannne Lewis
- Joby Cole
- Jocelyn Keshet-Price
- Jodie Hunt
- John Allan
- John Hardy
- John Norris
- John Rawlins
- John Smith
- Johnny Millar
- Jonathan Aldridge
- Jonathan Fox
- Jonathan Hatton
- Jonathan Hulme
- Jonathan Whiteside
- Jordan Alfonso
- Jordan Frankham
- Jordan Jarmain
- Jordi Barretina
- Jordi Margalef
- Jose Cebrian Suarez
- Joseph Carter
- Joseph Duffield
- Joseph Dykes
- Joshua Cooper
- Josie Goodsell
- Joslan Scherewode
- Joy Dawson
- Joy Dearden
- Joy Wilkins
- Judith Highgate
- Judith Highgate
- Judy Coyle
- Julia Heggemann
- Julia Hindale
- Julia Sampson
- Julian Knight
- Julian Shiel
- Julie Camsooksai
- Julie Colley
- Julie Melville
- Julie Newman
- Julie Newman
- Julie North
- Julie Summers
- Julie Tebbutt
- Julie Zamikula
- Juliet Parkin
- June Taylor
- K. Webster
- Kamal Liyanage
- Kamal Patel
- Kanta Mahay
- Karen Austin
- Karen Beaumont
- Karen Black
- Karen Burns
- Karen Burt
- Karen Castle
- Karen Connolly
- Karen Convery
- Karen Hansson
- Karen Jackson-Lawrence
- Karen Knowles
- Karen Reid
- Karen Salmon
- Karen Shuker
- Karen Williams
- Kat Rhead
- Katarina Manso
- Katarzyna Hafezi
- Kate Beesley
- Kate Briton
- Kate Colette Tatham
- Kate Darlington
- Kate Hammerton
- Kate Harrington
- Kate Howard
- Kate Long
- Kate Pye
- Katerina Stroud
- Katharine Duffy
- Katherine Mackintosh
- Katherine Schon
- Kathleen Holding
- Kathryn Birchall
- Kathryn Cawley
- Kathryn Hall
- Kathryn Hanson
- Kathryn Norman
- Kathryn Potts
- Kathryn Puxty
- Kathryn Sian Allison
- Kathryn Simpson
- Kathryn Slevin
- Kathryn Sollesta
- Kathy Brickell
- Kathy Dent
- Kathy Rowan
- Kati Hayes
- Katie Adams
- Katie Archer
- Katie Birchall
- Katie Dale
- Katie Douglas
- Katie Riches
- Katie Stammers
- Katie Sweet
- Katie White
- Katy Collins
- Katy English
- Katy Fidler
- Kay Cawthron
- Kay Elston
- Kay Fernandes
- Kay Housley
- Kayleigh Gilbert
- Kayleigh Spencer
- Keith Hugill
- Kelly Hard
- Kelly Holdroyd
- Kelly Pritchard
- Ken Inweregbu
- Keri Turner
- Kerry Elliott
- Kerry Simpson
- Kerry Smith
- Kerstin U. Ludwig
- Kevin Donnelly
- Kevin O'Reilly
- Kevin Rooney
- Kim Davies
- Kim Golder
- Kimberley Netherton
- Kimberley Rogerson
- Kirsten King
- Kirsten Sellick
- Kirstie Morrice
- Kirsty Prager
- Kizzy Baines
- Koldo Garcia-Etxebarria
- Komala Karthik
- Konrad Rawlik
- Kris Bauchmuller
- Kristine Criste
- Krithivasan Praman
- Kugan Xavier
- Kumar Rohit
- Lace Rosaroso
- Lai Lim
- Lance Turtle
- Lara Bunni
- Lara Smith
- Latha Aravindan
- Latha Durga
- Laura Bough
- Laura Catlow
- Laura Gomes de Almeida Martins
- Laura Harrison
- Laura Jayne Durrans
- Laura Johnson
- Laura King
- Laura O'Malley
- Laura Okeefe
- Laura Ortiz-Ruiz de Gordoa
- Laura Ortiz-Ruiz de Gordoa
- Laura Rachele Bettini
- Laura Rad
- Laura Rooney
- Laura Sweeney
- Laura Thrasyvoulou
- Laura Wild
- Laura Wilding
- Lauran O'Neill
- Laurel Kolakaluri
- Lauren Booker
- Leanne Milner
- Lear Matapure
- Lee Murphy
- Lee-Ann Bayo
- Lenka Cagova
- Leonie Benham
- Lesley Harden
- Lesley Stevenson
- Lesley Symon
- Lesley Thomis
- Letizia Zitter
- Lewis Mallon
- Li Lim
- Liam Botfield
- Liam McMorrow
- Liana Lankester
- Lidia Ramos
- Lijun Ding
- Lina Grauslyte
- Linda Folkes
- Linda O'Brien
- Linda Park
- Lindsey Woods
- Linsha George
- Lisa Armstrong
- Lisa Cooper
- Lisa Gemmell
- Lisa Gledhill
- Lisa Grimmer
- Lisa Hesseldon
- Lisa Hudig
- Lisa Roche
- Lisa Roche
- Lisa Shaw
- Liz Lennon
- Liz Nicol
- Liza Keating
- Llinos Davies
- Llucia Carbral-Ortega
- Lorenza Nwafor
- Lorenzo Miano
- Loreta Mostoles
- Lorna Donnelly
- Lorna Murphy
- Lorraine Stephenson
- Lorraine Thornton
- Louise Akeroyd
- Louise Allen
- Louise Cabrelli
- Louise Cullum
- Louise Findlay
- Louise Foster
- Louise Ma
- Louise Macgillivray
- Louise McCormack
- Louise Mew
- Louise Ting
- Louise Tonks
- Louise Wilcox
- Lowell Ling
- Luca V.C. Valenti
- Lucie Garner
- Lucy Barclay
- Lucy Gurr
- Lucy Howie
- Lucy Marshall
- Lucy Morris
- Lucy Mwaura
- Lucy Pippard
- Lucy Ryan
- Lucy Worsley
- Luigi Barberis
- Luigi Barberis
- Luis Bujanda
- Luisa Ronzoni
- Luke Chetam
- Luke Hodgson
- Luke Newey
- Luke Stephen Prockter Moore
- Luke Ward
- Lutece Brimfield
- Lydia Ashton
- Lynn Abel
- Lynn Glass
- Lynn Prentice
- Lynn Wren
- Lynne Turner
- Lynne Van Koutrik
- Maaike Swets
- Madeleine Anderson
- Maeve Cockrell
- Maggie Fearby
- Mahitha Gummadi
- Maia Aquino
- Maie Templeton
- Maines Msiska
- Mairi Mascarenhas
- Mairi Ward
- Malcolm G. Semple
- Malcolm Sim
- Malcolm Watters
- Malik Saleem
- Mandeep Phull
- Mandy Beekes
- Mandy Carnahan
- Mandy Gill
- Maninderpal Matharu
- Manish Chablani
- Manjit Purewal
- Manolis Kogevinas
- Manu Shankar-Hari
- Manu Shankar-Hari
- Marc Lyons
- Marcela Paola Vizcaychipi
- Margaret Carmody
- Margaret Langley
- Margaret Taylor
- Maria Alvarez Corral
- Maria Bokhari
- Maria Buti
- Maria Croft
- Maria Crowley
- Maria Depante
- Maria Faulkner
- Maria Grazia Valsecchi
- Maria Hobrok
- Maria Lazo
- Maria Lopez Martinez
- Maria Newton
- Maria Poulaka
- Maria Thanasi
- Maria Thompsom
- Marianne O'Hara
- Marie Callaghan
- Marie Home
- Marie Williams
- Marie Zechner
- Mariella D'Angiò
- Marina Elena Cazzaniga
- Marius Vaida
- Mark Birt
- Mark Blunt
- Mark Brunton
- Mark De Neef
- Mark J. Peters
- Mark McPhail
- Mark Verlander
- Mark Vertue
- Mark Vertue
- Marlies Ostermann
- Martin Dent
- Martin Hruska
- Martina Coulding
- Martina Marotti
- Martyn Clark
- Martyna Marani
- Marwa Abdelrazik
- Mary Bellamy
- Mary Hilton
- Mary Wright
- Maryanne Wills
- Mathew Varghese
- Matt Bromley
- Matt Casey
- Matt Thomas
- Matthew Bolton
- Matthew Collis
- Matthew Frise
- Matthew Halkes
- Matthew Jackson
- Matthew Robinson
- Matthew Smith
- Matthew White
- Matthew Wiles
- Maudrian Burton
- Maureen Holland
- Mauro D'Amato
- Max Head Fourman
- Mcdonald Mupudzi
- Meena Raj
- Meg Hibbert
- Megan Brady
- Megan Jones
- Megan Meredith
- Meherunnisa Khan
- Mel Hayman
- Melanie Caswell
- Melanie Clapham
- Melanie Kent
- Melanie Slaughter
- Melanie Taylor
- Melanie Taylor
- Melanie Tolson
- Melchizedek Penacerrada
- Meriel Woodruff
- Mervin Mahenthran
- Meryem Allen
- Metod Oblak
- Michael Bell
- Michael Bentley
- Michael Brett
- Michael Leigh
- Michael MacMahon
- Michael Margarson
- Michael McAlindon
- Michael Spivey
- Michaela Duskova
- Michaela Hill
- Michele Clark
- Michelle Bates
- Michelle Bruce
- Michelle Clarkson
- Michelle Davies
- Michelle Davies
- Michelle Edwards
- Michelle Male
- Michelle Mulcahy
- Michelle Smyth
- Mihaela Das
- Mini Thankachen
- Minnie Gellamucho
- Miranda Forsey
- Miranda Forsey
- Miranda Odam
- Miriam Davey
- Mirriam Sangombe
- Mishell Cunningham
- Mital Patel
- Mohamed Elsaadany
- Monalisa Nayak
- Monica Latif
- Monica Popescu
- Muhammad Hijazi
- Muhmmad Nauman Akhtar
- Munzir Elhassan
- Musarat Hussain
- Muthu Thirumaran
- Mybaya Hellen
- Mybaya Hellen
- Nageswar Bandla
- Naiara Cother
- Naomi Oakley
- Naomi Rogers
- Natalia Blay
- Natalia Michalak-Glinska
- Natalia Waddington
- Natalie Dormand
- Natalie Keenan
- Natalie Pattison
- Natalie Rodden
- Natalie Stroud
- Natasha Schumacher
- Nazima Pathan
- Neil Davidson
- Neil Flint
- Neil Richardson
- Neus Grau
- Niall MacCallum
- Nichola Harris
- Nichola Motherwell
- Nicholas Cowley
- Nicholas Love
- Nicholas Roe
- Nick Parkinson
- Nick Truman
- Nicky Day
- Nicola Baxter
- Nicola Butterworth-Cowin
- Nicola Jacques
- Nicola Lancaster
- Nicola Proudfoot
- Nicola Slawson
- Nicola Thomson
- Nicola Wrobel
- Nicoletta Sacchi
- Nigel Capps
- Nigel White
- Nikhil Bhatia
- Nikitas Nikitas
- Nikki Crisp
- Nikki White
- Nikki Yun
- Nikole Runciman
- Nirav Shah
- Noreen Clarke
- Norfaizan Ahmad
- Nycola Muchenje
- Obiageri Ezeobu
- Olaf Riess
- Oleksandra Prysyazhna
- Oliver Jones
- Oliver Mercer
- Oliver Mitchelmore
- Oliver Polgar
- Oliver Smith
- Olivia Kelsall
- Olivia Walton
- Olivier Zongo
- Olugbenga Akinkugbe
- Olumide Olufuwa
- Oluronke Adanini
- Owen Richards
- Pamela Bremmer
- Paolo Bonfanti
- Parisa Mahjoob
- Parminder Bhuie
- Patel Rekha
- Patricia Doble
- Patricia Turner
- Patricia Williams
- Patrick MacGoey
- Patrick Phillips
- Patrizia Ebano
- Paul Bradley
- Paul Dark
- Paul Fineran
- Paul Paul
- Paula Hilltout
- Paula Hutton
- Paula Rogers
- Paula Saunderson
- Pauline Austin
- Pauline Boyle
- Pauline Mercer
- Pauline O'Neil
- Pedro Silva
- Penny Parsons
- Peter Alexander
- Peter Anderson
- Peter Bamford
- Peter Barry
- Peter Harding
- Peter Horby
- Peter J. McGuigan
- Peter J.M. Openshaw
- Peter Jackson
- Peter May
- Peter O'Brien
- Petra Polgarova
- Phil Donnison
- Philip Robinson
- Philippa Springle
- Phillipa Wakefield
- Phoebe Coghlan
- Pietro Invernizzi
- Pippa Hartridge
- Polly Rice
- Poonam Ranga
- Pradeep Shanmugasundaram
- Prisca Gondo
- Priya Daniel
- Priyai Parkinson
- Rachael Campbell
- Rachael Campbell
- Rachael Dore
- Rachael Lucas
- Rachael Stead
- Rachel Anne Hughes
- Rachel Bolton
- Rachel Gascoyne
- Rachel Harford
- Rachel Law
- Rachel Lorusso
- Rachel Mutch
- Rachel Nixon
- Rachel Pollard
- Rachel Prout
- Rachel Rikunenko
- Rachel Thomas
- Rachel Vincent
- Rachel Walker
- Radha Sundaram
- Rafael de Cid
- Raine Astin-Chamberlain
- Rajdeep Sandhu
- Rajeev Jha
- Rajeev Jha
- Rajnish Saha
- Rajvinder Shokkar
- Raquel Gomez
- Ravi Bhatterjee
- Ravishankar Rao Baikady
- Rebecca Brady
- Rebecca Collins
- Rebecca Crowe
- Rebecca Cusack
- Rebecca Flanagan
- Rebecca Kanu
- Rebecca Lidstone-Scott
- Rebecca Marshall
- Rebecca Seaman
- Rebecca Tutton
- Rebecca Wilcox
- Rebecca Wolf-Roberts
- Rebekah Chan
- Rebekah Johnson
- Redmond Tully
- Reece Doonan
- Reena Khade
- Rehana Bi
- Remi Paramsothy
- Reni Jacob
- Retno Wulandari
- Rhianna Jones
- Rhiannan Harling
- Rhys Davies
- Richard Clark
- Richard Clark
- Richard Lean
- Richard Partridge
- Richard Price
- Richard Pugh
- Richard Simms
- Richard Stewart
- Rikki Crawley
- Risna Haq
- Rita Fernandes
- Rita Kumar
- Ritoo Kapoor
- Rizwana Kausar
- Rob Charnock
- Robert Hull
- Robert Parker
- Roceld Rojo
- Roger Thompson
- Rohit Saha
- Roman Genetu
- Romina Pepermans Saluzzio
- Ronda Loosley
- Roonak Nazari
- Rosaleen Herdman-Grant
- Rosalind Boyle
- Rosane Joseph
- Rosanna Asselta
- Rosario Lim
- Roseanna Matt
- Rosemary Harper
- Rosie Baruah
- Rosie Joy
- Rosie Reece-Anthony
- Ross Hendry
- Ross Kitson
- Rosslyn Halls
- Ruddy Jim
- Rugia Montaser
- Rumanah Girach
- Russell Barber
- Ruth Armstrong
- Ruth Bellwood
- Ruth Bowles
- Ruth Charlesworth
- Ruth Penn
- Ruth Tampsett
- Ruth Worner
- Ryan Howle
- Ryan O'Leary
- Ryan Shaw
- Sabi Gurung Rai
- Saima Ashraf
- Salah Turki
- Sally Humphreys
- Sally Pitts
- Sallyanne Trotman
- Salma Kadiri
- Sam Dale
- Sam Moultrie
- Samantha Anderson
- Samantha Coetzee
- Samantha Keenan
- Samantha Leggett
- Samantha Mellor
- Samantha Roche
- Sameena Mohamed Ally
- Samia Hussain
- Samiran Ray
- Samuel Hey
- Samuel Saad
- Sanal Jose
- Sandra Greer
- Sandra May
- Sandra Pearson
- Sara Bennett
- Sara Campos
- Sara Clohisey
- Sara Clohisey
- Sara Marsal
- Sara Mingo Garcia
- Sara Salmi
- Sara Smuts
- Sara Walker
- Sara-Beth Sutherland
- Sarah Bean
- Sarah Beavis
- Sarah Benyon
- Sarah Bird
- Sarah Blow
- Sarah Board
- Sarah Buckley
- Sarah Clamp
- Sarah Clark
- Sarah Clayton
- Sarah Cornell
- Sarah Farnell-Ward
- Sarah Hanley
- Sarah Hierons
- Sarah Jenkins
- Sarah Keith
- Sarah Law
- Sarah Liderth
- Sarah Marsh
- Sarah McCafferty
- Sarah Melling
- Sarah Mitchard
- Sarah Purvis
- Sarah Rowland-Jones
- Sarah Shelton
- Sarah Shepardson
- Sarah Stone
- Sarah Williams
- Sarah Winnard
- Sarwat Arif
- Sasha Carter
- Schvearn Allen
- Scott Latham
- Scott Warden
- Sean Cutler
- Serena Pelusi
- Shaman Jhanji
- Shameer Gopal
- Shamiso Masuko
- Shane McIvor
- Sharon Turney
- Shauna Bartley
- Sheena Murphy
- Sheena Quaid
- Sheila Morris
- Sheila Mtuwa
- Sheila Munt
- Shereen Bano
- Shiney Cherian
- Shona C. Moore
- Shondipon Laha
- Shruti Agrawal
- Shuying Wei
- Sian Gibson
- Sian Jones
- Sian Saha
- Sibet Joseph
- Silvia Tavares
- Simon Oxspring
- Simon Whiteley
- Sinduya Srikaran
- Sinead Donlon
- Sinead Kelly
- Siobhain Carmody
- Sivarupan Selvanayagam
- Sohphie Birch
- Sonia Sathe
- Sonia Sousa Arias
- Sonja Monnery
- Sophie Arnold
- Sophie Kennedy-Hay
- Sophie Murdoch
- Sophie Packham
- Sophie Twiss
- Sorrell Tilbey
- Soumendu Manna
- Srikanth Chukkambotla
- Srinivas Jakkula
- Stacey Duffy
- Stavros Fotiadis
- Stella Metherell
- Stephanie Bell
- Stephanie Finn
- Stephanie Lee
- Stephanie Rees
- Stephen Bonner
- Stephen Brett
- Stephen Cole
- Stephen Cole
- Stephen Digby
- Stephen Duberly
- Stephen Preston
- Steve Dodds
- Steve Rose
- Steven Henderson
- Steven Liggett
- Stuart D'Sylva
- Stuart McKechnie
- Stuart Moss
- Sue Mepham
- Sue Spencer
- Sukamal Das
- Suleman Mulla
- Sumit Kumar
- Sundeep Kaul
- Susan Anderson
- Susan Butler
- Susan Chapman
- Susan Fowler
- Susan Hope
- Susan O'Connell
- Susana Iraola-Guzmán
- Susannah Glasgow
- Susannah Leaver
- Susanne Cathcart
- Susie Ferguson
- Susie O'Sullivan
- Suzanne Allibone
- Suzanne Brooks
- Suzanne Campbell
- Suzanne Clements
- Suzanne Wood
- Suzie Marriott
- Sweyn Garrioch
- Syamlan Ali
- Tabitha Newman
- Tabitha Rees
- Tahera Patel
- Tahira Ishaq
- Tamas Szakmany
- Tammy Gilchrist
- Tara McHugh
- Tatiana Pogreban
- Taya Anderson
- Teishel Joefield
- Teresa Behan
- Teresa Scott
- Terry Martin
- Thogulava Kannan
- Thomas Bemand
- Thomas Kong
- Thomas Lamb
- Tim Geary
- Tim Martindale
- Tim Owen Jones
- Tim Smith
- Tim Smith
- Timothy Felton
- Timothy Walsh
- Tina Coventry
- Tinashe Samakomva
- Tobias Rankin
- Tom Lawton
- Tonicha Nortcliffe
- Tony Wackett
- Toran Williams
- Tracey Cosier
- Tracey Hodgkiss
- Tracie Arden
- Tracy Duncan
- Tracy Hazelton
- Tracy Lewis
- Tracy Marsden
- Tracy Wood
- Trevor Paterson
- Una Poultney
- Val Irvine
- Valeria Rimoldi
- Valerie Beech
- Valerie Joan Page
- Valli Ratnam
- Vanessa Linnett
- Vanessa Rivers
- Varun Sarathy
- Veronica Wagstaff
- Veronika Pristopan
- Vicky Martinson
- Vicky Thomas
- Vicky Thwaites
- Vicky Thwaites
- Victoria Bastion
- Victoria Bridgett
- Victoria Clark
- Victoria Frost
- Victoria Lake
- Victoria Maynard
- Victoria Maynard
- Victoria Parris
- Victoria Parris
- Victoria Slater
- Victoria Tuckey
- Victoria Turner
- Victoria Waugh
- Vidya Kasipandian
- Vikki Crickmore
- Vikram Anumakonda
- Vinodh Krishnamurthy
- Vinodh Krishnamurthy
- Vishal Amin
- Wall Alanna
- Waqas Khaliq
- Waqas Khaliq
- Watkins Claire
- Wendy Goddard
- Wendy Harrison
- Wendy McCormick
- West Joe
- Wiesia Woodyatt
- Wild Laura
- William James Hurt
- Wilna Oosthuyzen
- Xavier Farré
- Xinyi Qiu
- Yasmin Choudhury
- Yasmin Death
- Yasmin Hussain
- Yolanda Baird
- Yusuf Cheema
- Yvette Thirlwall
- Yvonne Jackson
- Zahira Maqsood
- Zakaula Belagodu
- Zena Bradshaw
- Ziortza Fernandez
- Zoe Alldis
- Zoe Coton
- Zoe Daly
- Zoe Garland
- Zoe Lamond
- Zoe Prime
- Zoe Scott
- Zohra Omar
- Zohreh Farzad
- Publication venue
- Elsevier
- Publication date
- 01/10/2024
- Field of study
Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (<60 years) cases with no reported clinical risk factors (n = 378), compared to 0.24% of controls (odds ratio [OR] = 12.3, p = 1.27 × 10−10). Incorporation of the results of either functional assays or protein modeling led to a pronounced increase in effect size (ORmax = 46.5, p = 1.74 × 10−15). Association signals for the X-chromosomal gene TLR7 were also detected in the female-only subgroup, suggesting the existence of additional mechanisms beyond X-linked recessive inheritance in males. Additionally, supporting evidence was generated for a contribution to severe COVID-19 of the previously implicated genes IFNAR2, IFIH1, and TBK1. Our results refine the genetic contribution of rare TLR7 variants to severe COVID-19 and strengthen evidence for the etiological relevance of genes in the interferon signaling pathway