Design criteria and performance parameters of an alpha irradiation device for cell studies

An alpha irradiation device is described that utilises a commercially available disc-shaped americium-241 source of 8 cm diameter. The alpha particles traverse a moving collimator and the source is rotated to reduce the influence of source inhomogeneities. Source, collimator and a shutter disc are mounted in a container which is flushed with helium to reduce energy losses of the alpha particles before reaching the exit foil. The shutter disc is activated by a computer-controlled step motor. The broad beam of alpha particles emerges from the exit window of the container with a remaining range in tissue of about 15 mu m. An intermittent computer-controlled use of a preabsorber makes it possible to reduce dose differences within a depth up to 12.5 mu m to not more than +or-3%. With the commercially available americium sources a dose rate of 0.2 Gy min-1 is reached; this can be increased by utilising a somewhat wider collimator

A slowly rotating perfect fluid body in an ambient vacuum

A global model of a slowly rotating perfect fluid ball in general relativity is presented. To second order in the rotation parameter, the junction surface is an ellipsoidal cylinder. The interior is given by a limiting case of the Wahlquist solution, and the vacuum region is not asymptotically flat. The impossibility of joining an asymptotically flat vacuum region has been shown in a preceding work.Comment: 7 pages, published versio

An eco-solution for track & trace of goods and third party logistics

This paper presents a new economic cost-effective solution known as the Web and telephony based method for tracking and tracing of goods and small and medium sized third party logistic providers. Considering that these companies usually operate on very flat margins, a comparison is made of the available track and trace technologies like GPS, mobile phone approximated GPS and Java based cell tracking in terms of costs, operating risks, and other evaluation criteria

His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation

The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions. Inactivation studies were performed with the same radiations. For both mutation and inactivation, the maximum effectiveness per unit absorbed dose was obtained for the characteristic X rays, which have a dose averaged linear energy transfer (LET) of roughly 10 keV/μm. The ratio of the effectiveness of this radiation to γ rays was 2 for inactivation and about 1.4 for the his+ reversion. For both end points the effectiveness decreases substantially at high LET, i.e., for the α particles and the Fe ions. The composition of the bottom and the top agar was the one recommended by Maron and Ames [Mutat. Res. 113, 173-215 (1983)] for application in chemical mutagenicity tests. The experiments with the less penetrating radiations differed from the usual protocol by utilization of a technique of plating the bacteria on the surface of the top agar. As in an earlier study [Roos et al., Radiat. Res. 104, 102-108 (1985)] greatly enhanced yields of mutations, relative to the spontaneous reversion rate, were obtained in these experiments by performing the irradiations 6 h after plating, which differs from the conventional procedure to irradiate the bacteria shortly after plating

Socio-technical paths and crossings in business development

In this paper an evolutionary model of business development is proposed, which links cooperationbetween organizations and their exchanges to path dependence and crossings.While the concept of path dependence restricts action to the exploitation of the existing path, theconcept of crossings emphasizes that within existing structures there are opportunities to take an otherpath. In a case study, over a period of twelve years the business development of a firm and itsevolving network relations are described. To find out if a firm can change is taken path, the conceptsof path dependence and crossings are explored along the cycle of development