343 research outputs found

    Torture On Trial: How The Alien Tort Statute May Expose The United States Government\u27s Illegal Extraordinary Rendition Program Through Its Use Of A Private Contractor

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    While traveling through Pakistan, British resident Binyam Mohamed (Mohamed) was arrested and handed over to U.S. government agents for four months of abusive first-round interrogation while denied access to a legal representation.\u2

    Exploring U.S. Air Force Online Communities of Practice: An Examination of Content Management Practices

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    The management of knowledge assets has become increasingly important as organizations recognize the strategic value of knowledge. In an attempt to capitalize on its potential, many organizations have turned to Internet technologies for capturing, managing and disseminating their vast amounts of explicit knowledge. One application of such technology can be found in the use of on-line collaborative workspaces. These virtual workspaces facilitate and promote an environment for capturing and sharing knowledge among members of a particular field, task, or common practice. Despite the implied efficiency of such an approach, an ever-increasing volume of information/knowledge may impede the ability of users to navigate successfully through the workspace thus undermining the user participation and illustrating the importance of effective content management (CM). This exploratory study uses case studies to examine the CM practices of eight U.S. Air Force online communities of practice. The findings suggest that the development of formal CM processes, and procedures may help solve future CM problems as well as increase the benefits associated with on-line CoP usage

    Physical separation from the mate diminishes male’s attentiveness towards other females: a study in monogamous prairie voles Microtus ochrogaster

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    We tested whether continuous cohabitation in monogamous voles affects the mated male’s attentiveness to his breeding partner versus another female. Each male was housed in a 3-chamber apparatus with a Focal female (FF) and a Control female (CF) for 13 days then placed in a T-maze to assess his attentiveness to and memory of those females. The Distal male remained physically separated from both females, but received their distal cues. The Separate male cohabited with the FF for 3 days then remained physically separated from both females. The Disrupt male’s continuous cohabitation with the FF was disrupted by having him physically separated from her after 10 days and placed with the CF for the last 3 days. The Continuous male cohabited continuously with the FF for 13 days. With females in the T-maze, the Separate and Disrupt males spent more time near the FF’s box and the Disrupt males spent more time manipulating the FF’s box than the CF’s box. The Separate males groomed themselves more when near the FF’s box than the CF’s box. The Distal and Continuous males’ attentiveness to the two females did not differ. Results suggest that physical distance from the partner may reduce male’s attentiveness toward other potential mates. Prairie voles might be similar to socially monogamous primates in using tactile cues as a signal for maintaining their social bonds

    Response to comment on 'Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity'

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    Lambert et al. question our retrospective and holistic epidemiological assessment of the role of chytridiomycosis in amphibian declines. Their alternative assessment is narrow and provides an incomplete evaluation of evidence. Adopting this approach limits understanding of infectious disease impacts and hampers conservation efforts. We reaffirm that our study provides unambiguous evidence that chytridiomycosis has affected at least 501 amphibian species

    Novel Interactome of \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e Myosin Type II Identified by a Modified Integrated Membrane Yeast Two-Hybrid (iMYTH) Screen

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    Nonmuscle myosin type II (Myo1p) is required for cytokinesis in the budding yeast Saccharomyces cerevisiae. Loss of Myo1p activity has been associated with growth abnormalities and enhanced sensitivity to osmotic stress, making it an appealing antifungal therapeutic target. The Myo1p tail-only domain was previously reported to have functional activity equivalent to the full-length Myo1p whereas the head-only domain did not. Since Myo1p tail-only constructs are biologically active, the tail domain must have additional functions beyond its previously described role in myosin dimerization or trimerization. The identification of new Myo1p-interacting proteins may shed light on the other functions of the Myo1p tail domain. To identify novel Myo1p-interacting proteins, and determine if Myo1p can serve as a scaffold to recruit proteins to the bud neck during cytokinesis, we used the integrated split-ubiquitin membrane yeast two-hybrid (iMYTH) system. Myo1p was iMYTH-tagged at its C-terminus, and screened against both cDNA and genomic prey libraries to identify interacting proteins. Control experiments showed that the Myo1p-bait construct was appropriately expressed, and that the protein colocalized to the yeast bud neck. Thirty novel Myo1p-interacting proteins were identified by iMYTH. Eight proteins were confirmed by coprecipitation (Ape2, Bzz1, Fba1, Pdi1, Rpl5, Tah11, and Trx2) or mass spectrometry (AP-MS) (Abp1). The novel Myo1p-interacting proteins identified come from a range of different processes, including cellular organization and protein synthesis. Actin assembly/disassembly factors such as the SH3 domain protein Bzz1 and the actin-binding protein Abp1 represent likely Myo1p interactions during cytokinesis

    Strengthening a culture of prevention in low- and middle-income countries: Balancing scientific expectations and contextual realities

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    Relevant initiatives are being implemented in low- and middle-income countries (LMICs) aimed at strengthening a culture of prevention. However, cumulative contextual factors constitute significant barriers for implementing rigorous prevention science in these contexts, as defined by guidelines from high-income countries (HICs). Specifically, disseminating a culture of prevention in LMICs can be impacted by political instability, limited health coverage, insecurity, limited rule of law, and scarcity of specialized professionals. This manuscript offers a contribution focused on strengthening a culture of prevention in LMICs. Specifically, four case studies are presented illustrating the gradual development of contrasting prevention initiatives in northern and central México, Panamá, and Sub-Saharan Africa. The initiatives share the common goal of strengthening a culture of prevention in LMICs through the dissemination of efficacious parenting programs, aimed at reducing child maltreatment and improving parental and child mental health. Together, these initiatives illustrate: (a) the relevance of adopting a definition of culture of prevention characterized by national commitments with expected shared contributions by governments and civil society, (b) the need to carefully consider the impact of context when promoting prevention initiatives in LMICs, (c) the iterative, non-linear, and multi-faceted nature of promoting a culture of prevention in LMICs, and (d) the importance of committing to cultural competence and shared leadership with local communities for the advancement of prevention science in LMICs. Implications for expanding a culture of prevention in LMICs are discussed

    Customs Law

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    This article summarizes important developments in 2014 in customs law, including U.S. judicial decisions, trade, legislative, administrative, and executive developments, as well as Canadian and European legal developments
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