The Australian Post-War Utopia: Reconsidering Herbert Evatt’s human rights contribution in the 1940’s

This thesis contests the assumption that Herbert Evatt’s 1940’s career was devoted to the promotion of a universal post-war human rights regime. As Australian Minister for External Affairs, Evatt developed an independent small state strategy that pursued a system of international democracy and social justice to facilitate the expansion of Australian influence in the Pacific and curb American hegemony. Evatt’s subscription to the White Australia Policy undermined the realization of human rights by strengthening domestic sovereignty against international intervention. Human rights became the vehicle through which Evatt sought to shape the post-war order for the benefit of Australian national interests

Technological development of Speedway: a review and analysis

From the available literature it is clear that very little experimental testing has been conducted on Speedway frames to date, yet investigations into the physical parameters are fundamental if the sport is to continue to progress technically. The literature suggests that additional investigations into Speedway could provide a beneficial outcome to the sport and produce an increase in the performance of the bike whilst keeping costs low. A technology road map of Speedway was created to assess the technical development of the sport since its establishment and determined the trend in the mainstream popularity of the sport. Torsional and virtual testing was carried out on the Speedway frame, determining key performance parameters and behaviour characteristics of the frame and resulted in a validated FEA model of the Speedway frame being developed. The work reported here facilitates the potential for further development to be undertaken on areas relating to Speedway and in particular the frame. Whilst a validated FEA model was created, the design of the frame could be further optimised to provide a beneficial performance outcome for Speedway

Re-thinking Learning Communities: Using Google+ to invigorate the curriculum and engage learners

This paper details an explorative and experimental project based in the Faculty of Health and Life Sciences at Oxford Brookes University. It is an example of how a virtual space can be used to support and develop a strong and dynamic learning community in which staff and students work alongside to co-produce learning resources to enhance campus-based learning activities. It is likely to be of interest to colleagues who have experienced difficulties with student engagement in virtual learning environments, and those who are interested in developing more dynamic lecture programmes

Enzyme-responsive RGD-functionalised substrates to influence mesenchymal stem cells

Regenerative medicine is a rapidly expanding field of science with an exhaustive volume of literature published on the different strategies used to repair diseased or injured tissue. Recently, stem cells have emerged as a promising candidate in this regard owing to their involvement in embryogenesis, homeostatic turnover and normal tissue repair. Despite this potential, stem cell-based therapies have yet to be fully established in a clinical setting owing to complications associated with their limited numbers, immunogenicity, tumour formation and the ethical considerations surrounding their usage. Furthermore, the mechanisms underlying stem cell differentiation are complex and not fully understood, thus expanding stem cell numbers and predictably directing their commitment toward a desired lineage, represent a major challenge for tissue regeneration strategies. In an attempt to circumvent these problems there is currently a rising interest in biomimetic materials that aim to reproduce the physical architecture, chemical composition and plasticity of the in vivo extracellular environment in an in vitro setting. Furthermore, the need to expand stem cells while maintaining the stem cell phenotype has prompted many to look to the stem cell niche for answers. At the centre of most cellular responses to the physical cues embedded within the ECM are integrins. Integrins are mechanosensitive membrane spanning receptors that link the ECM to the cytoskeleton and thus transmit information from outside the cell into the nucleus, affecting gene transcription via a series of intracellular signalling cascades. To that end, many biomimetic systems incorporate integrin- binding ligands such as the tripeptide RGD. In this work glass surfaces functionalised with RGD were used to study changes in mesenchymal stem cell (MSC) responses to increased integrin binding by using an enzymatic ‘switch’ to reveal surface-bound RGD peptides that have been masked by a large chemical cap (Fmoc). The results of this work demonstrated that RGD- functionalised substrates can support MSC growth and influence them to commit to a particular fate. MSCs on surfaces where integrin-ligand binding was blocked developed a fibroblast-like phenotype whereas MSC grown on surfaces that were later enzymatically digested to reveal the underlying RGD ligands developed an osteoblast phenotype similar to RGD controls

Trends in New South Wales infant hospital admission rates in the first year of life: population-based study

Objective: To examine the trends in hospital admissions in the first year of life and identify whether changes in maternal and infant risk factors explain any changes Design: Population-based study using de-identified linked health data. Participants: All 788,798 liveborn infants delivered in New South Wales from 2001 to 2009 with a linked birth and hospital record. Main outcome measures: The number of infants readmitted to hospital at least once, up to one year of age, per 100 livebirths each year; changes in maternal and infant risk factors were assessed using logistic regression. Results: The number of infants admitted to hospital up to age one decreased 10.5%, from 18.4 per 100 births in 2001 to 16.5 in 2009. Fifty five per cent of this decrease could be explained by changes in factors that are associated with likelihood of hospitalisation; length of stay during the birth admission, maternal age and maternal smoking. The rate of admissions for jaundice and feeding difficulties increased significantly over the study period, while admissions for infections decreased. Conclusions: There has been a decrease in the rate of infants admitted to hospital in the first year of life, which can be partly explained by increasing maternal age, decreasing maternal smoking and a shift to shorter length of hospital stay at birth. Improved maternal and neonatal care in hospital and increased postnatal support at home may have contributed to reduced risk of readmission. The introduction of government policies may explain the rest of the decrease

Chaordic learning systems: reconceptualising pedagogy for the digital age

This article focuses on an explorative and experimental project seeking to implement Chaordic Learning Systems (CLS) as a pedagogic approach in Higher Education. We outline a project that embraced technologies of Web 2.0 to show how both physical and virtual spaces can be used to support and develop a strong and dynamic learning community in which staff and students work alongside each other to co-produce learning resources. Drawing on theories of Communities of Practice and Situated Learning a new teaching framework was introduced to a Level 5 undergraduate module (7.5 ECTS credits) that had not, until this project, used both face-to-face and online learning tools to engage students in the critical and discursive debates pertaining to sport and physical culture. We undertook this project with the belief that Higher Education should be concerned with answering the calls of an increasingly digital society for whom learning is not restricted by the physical boundaries of the university or the political landscape within which learning finds itself

The impact of coronavirus disease 2019 on genitourinary and prostate cancer care and clinical trials: a qualitative exploration of the Australian and New Zealand experience.

Abstract: Purpose: This qualitative study aimed to understand the impact of the coronavirus disease 2019 pandemic from March to November 2020 on healthcare delivery and clinical trials for genitourinary (GU) cancers in Australia. Methods: Annually a pre‐conference workshop is hosted by the Australian New Zealand Urogenital and Prostate Cancer Trials Group for supportive care health professionals. In November 2020, those that selected to attend were invited to participate in a focus group. Workshop and focus group discussions were recorded and transcripts were analyzed thematically. Results: Seventy‐two individuals involved in GU cancer care and clinical trials took part. Participants described negative changes to GU cancer care and clinical trials from the pandemic due to reduced clinical services and increased wait times. Trial recruitment was paused temporarily during lockdowns, and standard treatment protocols were used to limit hospital visits. Trial process changes included electronic capture of informed consent, home delivery of oral medications, and delegations of assessments. These changes increased administrative activity for clinical trial teams and Human Research Ethics Committees. A transition to telehealth enabled continuity of service delivery and trials but reduced the opportunity for face‐to‐face patient consultations with increasing concern about the failure to detect supportive care needs. Conclusion: The pandemic has prompted a critical review of service delivery and clinical trials for people with GU cancers