Analysis of Variance in Neuroreceptor Ligand Imaging Studies

Radioligand positron emission tomography (PET) with dual scan paradigms can provide valuable insight into changes in synaptic neurotransmitter concentration due to experimental manipulation. The residual t-test has been utilized to improve the sensitivity of the t-test in PET studies. However, no further development of statistical tests using residuals has been proposed so far to be applied in cases when there are more than two conditions. Here, we propose the residual f-test, a one-way analysis of variance (ANOVA), and examine its feasibility using simulated [11C]raclopride PET data. We also re-visit data from our previously published [11C]raclopride PET study, in which 10 individuals underwent three PET scans under different conditions. We found that the residual f-test is superior in terms of sensitivity than the conventional f-test while still controlling for type 1 error. The test will therefore allow us to reliably test hypotheses in the smaller sample sizes often used in explorative PET studies

Generation of Large Angle Bimodal Sea States using a Single Segmented Wavemaker

International audienc

Improved transient water waves technique for the experimental estimation of ship responses.

National audienceWe consider the transient water waves technique for the experimental determination of Response Amplitude Operators (RAO) of a floating structure. The main advantage of this technique which consists in generating a wave focused near the model and analyzing the resulting motions, is that a single test is required to accurately estimate the RAO in a wide frequency range. The focused wave however may involve non-linear effects. We thus propose an improved method in which the response is linearized by means of crest and trough focusing. The method is applied to a model barge and compared to other classical methods such as regular, random and transient waves. Based on criteria like accuracy, time required and ease of use, focused waves technique appears to provide many advantages to determine RAOs

Génération de Houle Directionnelle Complexes dans le bassin de Centrale Nantes

National audienc

Reproduction Déterministe de Paquets de Vagues Focalisés en Bassin Physique et Numérique

National audienc

Numerical and Physical Experiments of Wave Focusing in Short-Crested Seas

International audienc

Higher Order Spectral Numerical Modeling of a 3D Wave Basin Compared to Experiments

International audienc