15 research outputs found

    THE UN-DESIGN AND DESIGN OF INSULIN: STRUCTURAL EVOLUTIONWITH APPLICATION TO THERAPEUTIC DESIGN

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    Instability and performance limits of distributed simulators of feedforward queueing networks

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    In this article we study the performance of distributed simulation of open feedforward queueing networks, by analyzing queueing models of message flows in distributed discrete event simulators. We view each logical process in a distributed simulation as comprising a message sequencer with associated message queues, followed aby an event processor. We introduce the idealized, but analytically useful, comcept of maximum lookahead. We show that, with quite general stochatstic assumptions for message arrival and time-stamp processes, the meassage queues are unstable for conservative sequencing, and for conservative sequencing with maximum lookahead and hence for optimistic resequencing, and for any resequenceing algorithm that does not employ interprocessor flow control. Finally, we provide formulas for the throughput of distributed simulators of feedforward queueing networks

    Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

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    The purpose of this research was to explore theapplication of ionic interactions between naproxen sodium (NS) and chitosan (CH) in complexes (NSC) prepared by tray drying (TD) and spray drying (SD) methods. Drug–polymer ratio (1:1) in the NSC was optimized on the basis of dialysis studies. The particulate systems of NSC were prepared by tray drying (TD) and spray drying (SD) methods. Release retarding polymers were added to the NSC and to the physical mixtures containing NS–CH and their effects on water uptake, matrix erosion and drug release at different pH were compared. Spray dried complexes (SDC) were spherical, free flowing, light and fine amorphous particles in contrast to the crystalline, hard, tenacious, irregularly shaped, denser tray dried complexes (TDC) with poor flowability. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and Fourier transform infrared (FTIR) patterns confirm the conversion of crystalline to high energy amorphous phase suitable for ionic interactions in NSC. Presence of release retarding polymers, kappa carrageenan and hydroxypropylmethylcellulose (HPMC) in the NSC compacts retarded the drug release and improved the matrix integrity. Carrageenan matrices exhibited more retardation than HPMC tablets. FTIR patterns, erosion, swelling and drug release from matrices support ionic interactions between NS and CH in NSC. The reasons for retarded drug release from the chitosan matrices at acidic pH include poor solubility of drug at acidic pH, formation of a rate limiting polymer gel barrier along the periphery of matrices and the ionic interactions between oppositely charged moieties
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