18 research outputs found
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer
The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. We demonstrate that MYC, miR-17-5p, and miR-20a are up-regulated by CCAT2 through TCF7L2-mediated transcriptional regulation. We further identify the physical interaction between CCAT2 and TCF7L2 resulting in an enhancement of WNT signaling activity. We show that CCAT2 is itself a WNT downstream target, which suggests the existence of a feedback loop. Finally, we demonstrate that the SNP status affects CCAT2 expression and the risk allele G produces more CCAT2 transcript. Our results support a new mechanism of MYC and WNT regulation by the novel lncRNA CCAT2 in colorectal cancer pathogenesis, and provide an alternative explanation of the SNP-conferred cancer risk
Serial entrepreneurship, organisational capital and access to venture capital
International audienc
Finance entrepreneuriale: Le créateur d’entreprise et les investisseurs en capital
International audienc
En quoi l’apparition des nouveaux acteurs du financement en capital peut-elle répondre au déficit d’investissement dans les jeunes entreprises de croissance ?
International audienc
Serial entrepreneurship, organisational capital and access to venture capital
International audienc
Dynamics and Performance of French Venture-Backed Firms: Empirical Evidence
International audienc
… Et pour quelques euros de plus : Une contribution à la connaissance des pratiques d’equity crowdfunding
International audienc
Entrepreneuriat répété, capital organisationnel et accès au financement par capital-risque
International audienc
The influence of prior entrepreneurial experience on the survival of start-ups: the case of French ICT start-ups financed by venture capital
International audienc