Thermodynamic Profiles of Galaxy Clusters from a Joint X-ray/SZ Analysis

We jointly analyze Bolocam Sunyaev-Zeldovich (SZ) effect and Chandra X-ray data for a set of 45 clusters to derive gas density and temperature profiles without using spectroscopic information. The sample spans the mass and redshift range $3 \times 10^{14} M_{\odot} \le M_{500} \le 25 \times 10^{14} M_{\odot}$ and $0.15\le z \le 0.89$. We define cool-core (CC) and non-cool core (NCC) subsamples based on the central X-ray luminosity, and 17/45 clusters are classified as CC. In general, the profiles derived from our analysis are found to be in good agreement with previous analyses, and profile constraints beyond $r_{500}$ are obtained for 34/45 clusters. In approximately 30% of the CC clusters our analysis shows a central temperature drop with a statistical significance of $>3\sigma$; this modest detection fraction is due mainly to a combination of coarse angular resolution and modest S/N in the SZ data. Most clusters are consistent with an isothermal profile at the largest radii near $r_{500}$, although 9/45 show a significant temperature decrease with increasing radius. The sample mean density profile is in good agreement with previous studies, and shows a minimum intrinsic scatter of approximately 10% near $0.5 \times r_{500}$. The sample mean temperature profile is consistent with isothermal, and has an intrinsic scatter of approximately 50% independent of radius. This scatter is significantly higher compared to earlier X-ray-only studies, which find intrinsic scatters near 10%, likely due to a combination of unaccounted for non-idealities in the SZ noise, projection effects, and sample selection.Comment: 42 pages, 52 figure

Measuring the dark matter velocity anisotropy in galaxy clusters

The Universe contains approximately 6 times more dark matter than normal baryonic matter, and a directly observed fundamental difference between dark matter and baryons would both be significant for our understanding of dark matter structures and provide us with information about the basic characteristics of the dark matter particle. We discuss one distinctive feature of dark matter structures in equilibrium, namely the property that a local dark matter temperature may depend on direction. This is in stark contrast to baryonic gases. We used X-ray observations of two nearby, relaxed galaxy clusters, under the assumptions of hydrostatic equilibrium and identical dark matter and gas temperatures in the outer cluster region, to measure this dark matter temperature anisotropy beta_dm, with non-parametric Monte Carlo methods. We find that beta_dm is greater than the value predicted for baryonic gases, beta_gas=0, at more than 3 sigma confidence. The observed value of the temperature anisotropy is in fair agreement with the results of cosmological N-body simulations and shows that the equilibration of the dark matter particles is not governed by local point-like interactions in contrast to baryonic gases.Comment: 5 pages, 3 figures, extended discussions, matches accepted versio

Clusters of Galaxies: New Results from the CLEF Hydrodynamics Simulation

Preliminary results are presented from the CLEF hydrodynamics simulation, a large (N=2(428)^3 particles within a 200 Mpc/h comoving box) simulation of the LCDM cosmology that includes both radiative cooling and a simple model for galactic feedback. Specifically, we focus on the X-ray properties of the simulated clusters at z=0 and demonstrate a reasonable level of agreement between simulated and observed cluster scaling relations.Comment: 7 pages, 4 figures, accepted for publication in Advances in Space Research (proceedings of the COSPAR 2004 Assembly, Paris

X-MAS2: Study Systematics on the ICM Metallicity Measurements

(Abridged)The X-ray measurements of the ICM metallicity are becoming more frequent due to the availability of powerful X-ray telescope with excellent spatial and spectral resolutions. The information which can be extracted from the measurements of the alpha-elements, like Oxygen, Magnesium and Silicon with respect to the Iron abundance is extremely important to better understand the stellar formation and its evolutionary history. In this paper we investigate possible source of bias connected to the plasma physics when recovering metal abundances from X-ray spectra. To do this we analyze 6 simulated galaxy clusters processed through the new version of our X-ray MAp Simulator, which allows to create mock XMM-Newton EPIC MOS1 and MOS2 observations. By comparing the spectroscopic results to the input values we find that: i) Fe is recovered with high accuracy for both hot (T>3 keV) and cold (T<2 keV) systems; at intermediate temperatures, however, we find a systematic overestimate which depends on the number counts; ii) O is well recovered in cold clusters, while in hot systems its measure may overestimate by a factor up to 2-3; iii) Being a weak line, the measurement of Mg is always difficult; despite of this, for cold systems (T<2 keV) we do not find any systematic behavior, while for very hot systems (T>5 keV) the spectroscopic measurement may be strongly overestimated up to a factor of 4; iv) Si is well recovered for all the clusters in our sample. We investigate in detail the nature of the systematic effects and biases found. We conclude that they are mainly connected with the multi-temperature nature of the projected observed spectra and to the intrinsic limitation of the XMM-Newton EPIC spectral resolution that does not always allow to disentangle among the emission lines produced by different elements.Comment: (e.g.: 17 pages, 8 figures, accepted for publication in the Astrophysical Journal, updated discussion to match published version-new section:6.3

Massive Halos in Millennium Gas Simulations: Multivariate Scaling Relations

The joint likelihood of observable cluster signals reflects the astrophysical evolution of the coupled baryonic and dark matter components in massive halos, and its knowledge will enhance cosmological parameter constraints in the coming era of large, multi-wavelength cluster surveys. We present a computational study of intrinsic covariance in cluster properties using halo populations derived from Millennium Gas Simulations (MGS). The MGS are re-simulations of the original 500 Mpc/h Millennium Simulation performed with gas dynamics under two different physical treatments: shock heating driven by gravity only (GO) and a second treatment with cooling and preheating (PH). We examine relationships among structural properties and observable X-ray and Sunyaev-Zel'dovich (SZ) signals for samples of thousands of halos with M_200 > 5 \times 10^{13} Msun/h and z < 2. While the X-ray scaling behavior of PH model halos at low-redshift offers a good match to local clusters, the model exhibits non-standard features testable with larger surveys, including weakly running slopes in hot gas observable--mass relations and ~10% departures from self-similar redshift evolution for 10^14 Msun/h halos at redshift z ~ 1. We find that the form of the joint likelihood of signal pairs is generally well-described by a multivariate, log-normal distribution, especially in the PH case which exhibits less halo substructure than the GO model. At fixed mass and epoch, joint deviations of signal pairs display mainly positive correlations, especially the thermal SZ effect paired with either hot gas fraction (r=0.88/0.69 for PH/GO at z=0) or X-ray temperature (r=0.62/0.83). We discuss halo mass selection by signal pairs, and find a minimum mass scatter of 4% in the \PH model by combining thermal SZ and gas fraction measurements.Comment: 19 pages, 14 figures, submitted to Ap

In vitro and ex vivo effect of hyaluronic acid on erythrocyte flow properties

<p>Abstract</p> <p>Background</p> <p>Hyaluronic acid (HA) is present in many tissues; its presence in serum may be related to certain inflammatory conditions, tissue damage, sepsis, liver malfunction and some malignancies. In the present work, our goal was to investigate the significance of hyaluronic acid effect on erythrocyte flow properties. Therefore we performed <it>in vitro </it>experiments incubating red blood cells (RBCs) with several HA concentrations. Afterwards, in order to corroborate the pathophysiological significance of the results obtained, we replicated the <it>in vitro </it>experiment with <it>ex vivo </it>RBCs from diagnosed rheumatoid arthritis (RA) patients, a serum HA-increasing pathology.</p> <p>Methods</p> <p>Erythrocyte deformability (by filtration through nucleopore membranes) and erythrocyte aggregability (EA) were tested on blood from healthy donors additioned with purified HA. EA was measured by transmitted light and analyzed with a mathematical model yielding two parameters, the aggregation rate and the size of the aggregates. Conformational changes of cytoskeleton proteins were estimated by electron paramagnetic resonance spectroscopy (EPR).</p> <p>Results</p> <p><it>In vitro</it>, erythrocytes treated with HA showed increased rigidity index (RI) and reduced aggregability, situation strongly related to the rigidization of the membrane cytoskeleton triggered by HA, as shown by EPR results. Also, a significant correlation (r: 0.77, p < 0.00001) was found between RI and serum HA in RA patients.</p> <p>Conclusions</p> <p>Our results lead us to postulate the hypothesis that HA interacts with the erythrocyte surface leading to modifications in erythrocyte rheological and flow properties, both <it>ex vivo </it>and <it>in vitro</it>.</p

Structural characterization of copper(II) binding to α-Synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

The aggregation of α -synuclein (AS) is characteristic of Parkinson’s disease and other neurodegenerative synucleinopathies. We demonstrate here that Cu(II) ions are effective in accelerating AS aggregation at physiologically relevant concentrations without altering the resultant fibrillar structures. By using numerous spectroscopic techniques (absorption, CD, EPR, and NMR), we have located the primary binding for Cu(II) to a specific site in the N terminus, involving His-50 as the anchoring residue and other nitrogen oxygen donor atoms in a square planar or distorted tetragonal geometry. The carboxylate-rich C terminus, originally thought to drive copper binding, is able to coordinate a second Cu(II) equivalent, albeit with a 300-fold reduced affinity. The NMR analysis of AS–Cu(II) complexes reveals the existence of conformational restrictions in the native state of the protein. The metallobiology of Cu(II) in Parkinson’s disease is discussed by a comparative analysis with other Cu(II)-binding proteins involved in neurodegenerative disorders

Effects of Selection and Covariance on X-ray Scaling Relations of Galaxy Clusters

We explore how the behavior of galaxy cluster scaling relations are affected by flux-limited selection biases and intrinsic covariance among observable properties. Our models presume log-normal covariance between luminosity (L) and temperature (T) at fixed mass (M), centered on evolving, power-law mean relations as a function of host halo mass. Selection can mimic evolution; the \lm and \lt relations from shallow X-ray flux-limited samples will deviate from mass-limited expectations at nearly all scales while the relations from deep surveys (10^{-14} \cgsflux) become complete, and therefore unbiased, at masses above \sims 2 \times 10^{14} \hinv \msol. We derive expressions for low-order moments of the luminosity distribution at fixed temperature, and show that the slope and scatter of the \lt relation observed in flux-limited samples is sensitive to the assumed \lt correlation coefficient. In addition, \lt covariance affects the redshift behavior of halo counts and mean luminosity in a manner that is nearly degenerate with intrinsic population evolution.Comment: 5pages, 4 Figures, Submitted to MNRA

LoCuSS: Comparison of Observed X-ray and Lensing Galaxy Cluster Scaling Relations with Simulations

The Local Cluster Substructure Survey (LoCuSS, Smith et al.) is a systematic multi-wavelength survey of >100 X-ray luminous galaxy clusters (0.14<z<0.3) selected from the ROSAT all sky survey. We used data on 37 LoCuSS clusters from the XMM-Newton archive to investigate the global scaling relations of galaxy clusters. The scaling relations based solely on the X-ray data obey empirical self-similarity and reveal no additional evolution beyond the LSS growth. Weak lensing mass measurements are also available in the literature for 19 of the clusters with XMM-Newton data. The average of the weak lensing mass to X-ray based mass ratio is 1.09+/-8, setting the limit of the non-thermal pressure support to 9+/-8%. The mean of the weak lensing mass to X-ray based mass ratio of these clusters is ~1 with 31-51% scatter. The scatter in the mass--observable relations (M-Y_X, M-M_{gas} and M-T) is smaller using X-ray based masses than using weak lensing masses by a factor of 2. Using the scaled radius defined by the Y_X profile, we obtain lower scatter in the weak lensing mass based mass--observable relations. The normalization of the M-Y_X relation (also M-M_{gas} and M-T relations) using X-ray (weak lensing) mass estimates is lower than the one from simulations by up to 20% at ~3 sigma (~2 sigma) significance. Despite the large scatter in the X-ray to lensing comparison, the agreement between these two completely independent observational methods is an important step towards controlling astrophysical and measurement systematics in cosmological scaling relations.Comment: 56 pages, 32 figure, 2008A&A...482..451Z, typos corrected in Table A.