The relationship between clinical-demographic factors with adjustment to infertility in women in Iran

Infertility is an intense and prolonged stressful experience. Despite the high prevalence of infertility and its emotional burden for couples and especially for women, our knowledge regarding factors influencing adjustment to it is limited. The aim of the present study was to investigate the relationship between demographic and clinical factors and adjustment to infertility in women in Iran. A total number of 275 women referring to infertility clinic of Valie-Asr Reproductive Health Research Center (Tehran Imam Khomeini hospital) participated in the study. Data was collected via demographic information questionnaire, Adjustment to Illness Scale (AIS), and Depression Anxiety Stress Scale (DASS). Results showed there were significant relationships between infertility duration and depressionn (p<0/05) and number of treatments had significant relationship with depression (p<0/05) and adjustment (p<0/01). There were also significant differences in scores of depression, anxiety, stress and adjustment in women with different educational levels, women living in Tehran and other cities and women who were employed or housewives. These results can be helpful in identifying high risk patients and planning psychological interventions

Effect of intramural uterine myoma on the outcome of ART cycles

Background: Although the uterine fibroids are common, their influence on fertility remains controversial. The association of submucosal fibroid with subfertility is well recognized, but debate persists as to whether intramural fibroids can cause infertility and the evidence for its effect on pregnancy in cycles of assisted conception remains unclear. Objective: The purpose of present study was to determine the effect of intramural fibroids less than 6 cm not compressing uterine cavity on the outcome of ART cycles in patients undergoing IVF/ICSI cycles. Materials and Methods: In this prospective cohort study, 94 women with uterine intramural fibroids and 184 controls referred to Royan Institute between 2001 and 2002 were enrolled. The intramural fibroids and their location were detected by transvaginal ultrasound performed just before the ART cycle. All patients underwent long standard GnRH agonist protocol. Student t-test and Chi-square test were used for the statistical analysis. Results: The mean age of patients was 33.9 ±3.37 years in myoma group (n=94) and 33.28 ±3.59 years in control group (n=184). The total dose of gonadotropin used, estradiol level on day of hCG administration, the number of metaphase II oocytes retrieved, fertilization rate, number and quality of embryos developed and transferred, the clinical pregnancy and abortion rates were similar in two groups. Conclusion: The presence of intramural fibroids less than 6 cm not compressing endometrial cavity does not adversely affect clinical pregnancy rate in patients undergoing IVF or ICSI