Uncertainty quantification for personalized analyses of human proximal femurs

Computational models for the personalized analysis of human femurs contain uncertainties in bone material properties and loads, which affect the simulation results. To quantify the influence we developed a probabilistic framework based on polynomial chaos (PC) that propagates stochastic input variables through any computational model. We considered a stochastic E-ρ relationship and a stochastic hip contact force, representing realistic variability of experimental data. Their influence on the prediction of principal strains (ϵ1 and ϵ3) was quantified for one human proximal femur, including sensitivity and reliability analysis. Large variabilities in the principal strain predictions were found in the cortical shell of the femoral neck, with coefficients of variation of Math Eq. Between 60-80% of the variance in ϵ1 and ϵ3 are attributable to the uncertainty in the E-ρ relationship, while Math Eq are caused by the load magnitude and 5-30% by the load direction. Principal strain directions were unaffected by material and loading uncertainties. The antero-superior and medial inferior sides of the neck exhibited the largest probabilities for tensile and compression failure, however all were very small (Math Eq). In summary, uncertainty quantification with PC has been demonstrated to efficiently and accurately describe the influence of very different stochastic inputs, which increases the credibility and explanatory power of personalized analyses of human proximal femurs

A Parallel High-Order Fictitious Domain Approach for Biomechanical Applications

The focus of this contribution is on the parallelization of the Finite Cell Method (FCM) applied for biomechanical simulations of human femur bones. The FCM is a high-order fictitious domain method that combines the simplicity of Cartesian grids with the beneficial properties of hierarchical approximation bases of higher order for an increased accuracy and reliablility of the simulation model. A pre-computation scheme for the numerically expensive parts of the finite cell model is presented that shifts a significant part of the analysis update to a setup phase of the simulation, thus increasing the update rate of linear analyses with time-varying geometry properties to a range that even allows user interactive simulations of high quality. Paralellization of both parts, the pre-computation of the model stiffness and the update phase of the simulation is simplified due to a simple and undeformed cell structure of the computation domain. A shared memory parallelized implementation of the method is presented and its performance is tested for a biomedical application of clinical relevance to demonstrate the applicability of the presented method

Phase-field modeling of brittle fracture with multi-level hp-FEM and the finite cell method

The difficulties in dealing with discontinuities related to a sharp crack are overcome in the phase-field approach for fracture by modeling the crack as a diffusive object being described by a continuous field having high gradients. The discrete crack limit case is approached for a small length-scale parameter that controls the width of the transition region between the fully broken and the undamaged phases. From a computational standpoint, this necessitates fine meshes, at least locally, in order to accurately resolve the phase-field profile. In the classical approach, phase-field models are computed on a fixed mesh that is a priori refined in the areas where the crack is expected to propagate. This on the other hand curbs the convenience of using phase-field models for unknown crack paths and its ability to handle complex crack propagation patterns. In this work, we overcome this issue by employing the multi-level hp-refinement technique that enables a dynamically changing mesh which in turn allows the refinement to remain local at singularities and high gradients without problems of hanging nodes. Yet, in case of complex geometries, mesh generation and in particular local refinement becomes non-trivial. We address this issue by integrating a two-dimensional phase-field framework for brittle fracture with the finite cell method (FCM). The FCM based on high-order finite elements is a non-geometry-conforming discretization technique wherein the physical domain is embedded into a larger fictitious domain of simple geometry that can be easily discretized. This facilitates mesh generation for complex geometries and supports local refinement. Numerical examples including a comparison to a validation experiment illustrate the applicability of the multi-level hp-refinement and the FCM in the context of phase-field simulations