Development and Characterization of Eudragit RS 100 Loaded Microsponges and its Colonic Delivery Using Natural Polysaccharides

In the present work, paracetamol loaded eudragit based microsponges were prepared using quasi-emulsion solvent diffusion method. The compatibility of the drug with various formulation components was established. Process parameters were analyzed in order to optimize the formulation. Shape and surface morphology of the microsponges were examined using scanning electron microscopy. The colon specific formulations were prepared by compression coating of microsponges with pectin:hydroxypropylmethylcellulose (HPMC) mixture followed by tabletting. The in vitro dissolution studies were done on all formulations and the results were evaluated kinetically and statically. The kinetics of release study showed that the release data followed Higuchi matrix and the main mechanism of drug release from microsponges was diffusion. In vitro studies exhibited that compression coated colon specific tablet formulations started the release the drug at the 6th hour corresponding to the arrival time to proximal colon

Operation Lal Dora: India's aborted military intervention in Mauritius

As India expands its strategic reach in the Indian Ocean, it will need friends that it can count on. The island state of Mauritius has long been one of India's closest allies in the region. This article discusses India's plans for a military intervention in Mauritius in 1983 to prevent a feared coup that may have threatened India's interests. A naval task force was readied, but the intervention did not proceed because of disagreements in India's leadership. Instead New Delhi facilitated a political solution to the crisis that firmly consolidated its special role. This previously undisclosed episode sheds light on India's thinking about the Indian Ocean, the alignment of India's interests with the United States, and India's military capabilities

ASEAN: perspectives on economic integration: ASEAN capital market integration: issues and challenges

I am grateful for the assistance of Kaleon Leong and Chong Wui Jean in the preparation of this paper. The paper draws on the work of the ASEAN Integration plan and other related papers for which the author gratefully acknowledges. The views expressed in the paper do not necessarily reflect the views of the Securities Commission