Microsatellite instability predicts response to anti-PD1 immunotherapy in metastatic melanoma

No abstract available</p

Thin Melanoma: a Generic Term Including Four Histological Subtypes of Cutaneous Melanoma

No abstract available</p

Sudden infant death syndrome: revealing this mystery is possible

Dear Editor, The sudden and unexpected loss of an infant in the first months of life is a heartbreaking and devastating experience for any parent. Understandably, it can be an extremely distressing time for the mother, who may often find herself unfairly burdened with guilt. When this tragic event occurs, a thorough investigation becomes necessary to determine the cause of death and also absolve the mother of any responsibility. [...

The "Hepatic core": how to reach it

The "hepatic core" has to be considered a zone inside the hepatic parenchyma where different liver segments converge

The association between tumor-infiltrating lymphocytes (TILs) and metastatic course in neuroendocrine neoplasms.

A moderate lymphocytic infiltration was found in about 25% of these well-differentiated neoplasms, all of which had no distant metastases to liver or pulmonary hilar lymph nodes during a follow-up period &gt;10&nbsp;years; mild or absent lymphocytic infiltrates have been observed in those cases with metastatic spread, discovered synchronously or after follow-up of 10&nbsp;years (P&nbsp;&lt;&nbsp;.05)

Microinvasive radial growth phase of cutaneous melanoma: A histopathological and immunohistochemical study with diagnostic implications

Cutaneous melanoma (M) can develop through two progression phases: the radial growth phase of M (RGPM) and the vertical one. This distinction has a practical relevance in defining lesions with potential for a metastatic course. We analyzed the morphological attributes (intraepidermal proliferation type, inflammatory infiltrate, mitogenicity, Breslow thickness, Clark level, ulceration) and the immunohistochemical profile (S100, Melan A, HMB45, p16INK4a, CD117, Ki67, Cyclin D1, E Cadherin, Podoplanin) of 12 microinvasive RGPMs in absence of regression, with almost 10 years of follow-up. Immunohistochemistry (IHC) revealed that S100, Melan A, and HMB45 maintain a high expression in M cells in both epidermal and dermal compartments. Interestingly, an overexpression of p16INK4a in the nests of dermal microinvasion has been ascertained in all our cases. On the other hand, we found an attenuation of expression for CD117, Ki67, Cyclin D1, and E Cadherin in the migration phase from the epidermis to dermis. Each phase in M progression appears characterized by a specific immunohistochemical profile, as a result of molecular alterations. The long-term follow-up of our case series showed that microinvasive RGPM without regression is not tumori-genic and is devoid of metastatic potential; therefore, its accurate categorization is important. Conversely, microinvasive RGPM with regression should be classified as melanocytic tumor with uncertain biological potential. IHC for p16INK4a can be helpful in the diagnosis of microinvasive M on challenging cutaneous biopsies. Moreover, it can be applied as an immunohistochemical discriminator to distinguish microinvasive RGPM from in situ RGPM and microinvasive RGPM from dysplastic nevi

Subcutaneous Cavernous Angiolipoma: a New Soft-tissue Entity

No Abstract available</p