34 research outputs found
Association between biomarkers of inflammation and left ventricular hypertrophy in moderate chronic kidney disease
Relationship between obesity and plasma aldosterone in essential hypertension: influence of gender
Fetuina e massa ventricolare nell’ipertensione essenziale e nell’insufficienza renale cronica di grado moderato
Fetuin-A and left ventricular mass in essential hypertension and in moderate chronic kidney disease.
Markers di fibrosi miocardica e di infiammazione in ipertesi con e senza ipertrofia ventricolare sinistra
Markers di fibrosi miocardica e di infiammazione in ipertesi con e senza ipertrofia ventricolare.
Fetuina e massa ventricolare sinistra nell'ipertensione essenziale e nell'insufficienza renale cronica
The Relationship between an Oxidative Stress Biomarker and Plasma Haemoglobin in Patients with Chronic Kidney Disease
Introduction Evidence suggests that decreased haemoglobin plasma concentration may be a predictor of adverse cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that in CKD patients, oxidative stress could influence the development of cardiovascular damage via a relationship with haemoglobin levels.
Methods We assayed plasma levels of the biomarker of oxidative stress 8-ISO-prostaglandin F2α (8-ISO-PGF2α) and of haemoglobin in 193 stage 2-5 CKD patients, investigating their relationship. Eighty healthy subjects and 80 patients with primary hypertension having normal renal function were enrolled as controls.
Results The CKD group was divided according to 8-ISO-PGF2α quartiles, and decreasing levels of both haemoglobin and estimated glomerular filtration rate (eGFR) along with increasing quartiles were observed. In the 193 CKD patients, the linear analysis of correlation showed inverse correlations of 8-ISO-PGF2α with both haemoglobin and eGFR (r = −0.47; r = −0.81; p < 0.00001, respectively). In the control groups, no correlation between haemoglobin and 8-ISO-PGF2α was found. The multiple regression analysis carried out in CKD patients, by a model with 8-ISO-PGF2α as the dependent variable, and including haemoglobin and all confounding factors, confirmed the inverse relationship between haemoglobin and 8-ISO-PGF2α (β = −0.50; p < 0.00001). In this model, only when eGFR was added did the relationship between haemoglobin and 8-ISO-PGF2α lose statistical significance. In this final multivariate model, 8-ISO-PGF2α correlated independently with eGFR (β = −0.82; p < 0.0001).
Conclusions In CKD, haemoglobin plasma level is inversely related to oxidative stress, depending on GFR. It remains to be elucidated whether or not the biochemistry of nitric oxide and haemoglobin interaction has a role in causing this relationship
Fetuina e massa ventricolare sinistra nell’ipertensione essenziale e nell’insufficienza renale
Parathyroid hormone is inversely related to endothelin-1 in patients on haemodialysis
Aim: Parathyroid hormone secretion is mainly influenced by hypocalcaemia, hyperphosphataemia and vitamin
D deficiency. However, previous in vitro and in vivo studies showed that endothelin-1 can influence parathyroid
hormone secretion. This study was aimed at evaluating this relationship in vivo in uraemic patients.
Methods: Parathyroid hormone and endothelin-1 plasma concentrations were measured in 67 haemodialysed
patients. Patients with history of cardiovascular diseases and those with parathyroid adenoma were excluded.
Results: Plasma levels of endothelin-1 were found to be inversely related to those of parathyroid hormone
(P < 0.04) The multiple regression analysis, carried out considering parathyroid hormone as a dependent
variable, and including age, sex, blood pressure, calcium ¥ phosphorus product, and endothelin-1, demonstrated
that the independent correlates of parathyroid hormone were endothelin-1 (b = -0.276; P = 0.015), and calcium
Â¥ phosphorus product (b = 0.417; P < 0.0001).
Conclusion: For the first time in vivo, we demonstrated an inverse independent relationship between
endothelin-1 and parathyroid hormone in haemodialysed patients. Because both endothelin-1 and parathyroid
hormone are endowed with well-known harmful actions on cardiovascular apparatus, whether such inverse
relation may really influence the natural history of cardiovascular damage due to secondary hyperparathyroidism
remains to be elucidated