3,711 research outputs found
Novel designs for Penning ion traps
Project supported by the European Commission within the FP5 RTD programmes HITRAP and QGATES and the Integrated Project FET/QIPC “SCALA” FP6. We also acknowledge the support from the EPSRC. JRCP acknowledges the support by CONACyT, SEP and the ORS Awards
High Energy Gamma-Ray Emission From Blazars: EGRET Observations
We will present a summary of the observations of blazars by the Energetic
Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory
(CGRO). EGRET has detected high energy gamma-ray emission at energies greater
than 100 MeV from more that 50 blazars. These sources show inferred isotropic
luminosities as large as ergs s. One of the most
remarkable characteristics of the EGRET observations is that the gamma-ray
luminosity often dominates the bolometric power of the blazar. A few of the
blazars are seen to exhibit variability on very short time-scales of one day or
less. The combination of high luminosities and time variations seen in the
gamma-ray data indicate that gamma-rays are an important component of the
relativistic jet thought to characterize blazars. Currently most models for
blazars involve a beaming scenario. In leptonic models, where electrons are the
primary accelerated particles, gamma-ray emission is believed to be due to
inverse Compton scattering of low energy photons, although opinions differ as
to the source of the soft photons. Hardronic models involve secondary
production or photomeson production followed by pair cascades, and predict
associated neutrino production.Comment: 16 pages, 7 figures, style files included. Invited review paper in
"Observational Evidence for Black Holes in the Universe," 1999, ed. S. K.
Chakrabarti (Dordrecht: Kluwer), 215-23
Plans for laser spectroscopy of trapped cold hydrogen-like HCI
Laser spectroscopy studies are being prepared to measure the 1s ground state
hyperfine splitting in trapped cold highly charged ions. The purpose of such
experiments is to test quantum electrodynamics in the strong electric field
regime. These experiments form part of the HITRAP project at GSI. A brief
review of the planned experiments is presented.Comment: 4 pages, 4 figures, accepted for publication (NIMB
On Semiclassical Limits of String States
We explore the relation between classical and quantum states in both open and
closed (super)strings discussing the relevance of coherent states as a
semiclassical approximation. For the closed string sector a gauge-fixing of the
residual world-sheet rigid translation symmetry of the light-cone gauge is
needed for the construction to be possible. The circular target-space loop
example is worked out explicitly.Comment: 12 page
Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of disrupted CNP and GC-B indicate a potential role in growth hormone secretion. In the current study, we investigate the molecular and pharmacological properties of the CNP/GC-B system in somatotrope lineage cells. Primary rat pituitary and GH3 somatolactotropes expressed functional GC-A and GC-B receptors that had similar EC50 properties in terms of cGMP production. Interestingly, GC-B signaling underwent rapid homologous desensitization in a protein phosphatase 2A (PP2A)-dependent manner. Chronic exposure to either CNP or ANP caused a significant down-regulation of both GC-A- and GC-B-dependent cGMP accumulation in a ligand-specific manner. However, this down-regulation was not accompanied by alterations in the sub-cellular localization of these receptors. Heterologous desensitization of GC-B signaling occurred in GH3 cells following exposure to either sphingosine-1-phosphate or thyrotrophin-releasing hormone (TRH). This heterologous desensitization was protein kinase C (PKC)-dependent, as pre-treatment with GF109203X prevented the effect of TRH on CNP/GC-B signaling. Collectively, these data indicate common and distinct properties of particulate guanylyl cyclase receptors in somatotropes and reveal that independent mechanisms of homologous and heterologous desensitization occur involving either PP2A or PKC. Guanylyl cyclase receptors thus represent potential novel therapeutic targets for treating growth-hormone-associated disorders
Nuclei in Strongly Magnetised Neutron Star Crusts
We discuss the ground state properties of matter in outer and inner crusts of
neutron stars under the influence of strong magnetic fields. In particular, we
demonstrate the effects of Landau quantization of electrons on compositions of
neutron star crusts. First we revisit the sequence of nuclei and the equation
of state of the outer crust adopting the Baym, Pethick and Sutherland (BPS)
model in the presence of strong magnetic fields and most recent versions of the
theoretical and experimental nuclear mass tables. Next we deal with nuclei in
the inner crust. Nuclei which are arranged in a lattice, are immersed in a
nucleonic gas as well as a uniform background of electrons in the inner crust.
The Wigner-Seitz approximation is adopted in this calculation and each lattice
volume is replaced by a spherical cell. The coexistence of two phases of
nuclear matter - liquid and gas, is considered in this case. We obtain the
equilibrium nucleus corresponding to each baryon density by minimizing the free
energy of the cell. We perform this calculation using Skyrme nucleon-nucleon
interaction with different parameter sets. We find nuclei with larger mass and
charge numbers in the inner crust in the presence of strong magnetic fields
than those of the zero field case for all nucleon-nucleon interactions
considered here. However, SLy4 interaction has dramatic effects on the proton
fraction as well as masses and charges of nuclei. This may be attributed to the
behaviour of symmetry energy with density in the sub-saturation density regime.
Further we discuss the implications of our results to shear mode oscillations
of magnetars.Comment: presented in "Exciting Physics Symposium" held in Makutsi, South
Africa in November, 2011 and to be published in a book by Springer Verla
Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.
The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and GC-B) to generate cGMP. Whereas cGMP-independent signalling has been reported in response to natriuretic peptides, this is mediated via either the clearance receptor (Npr-C) or a renal-specific NPR-Bi isoform, which both lack intrinsic guanylyl cyclase activity. Here, we report evidence of GC-B-dependent cGMP-independent signalling in pituitary GH3 cells. Stimulation of GH3 cells with CNP resulted in a rapid and sustained enhancement of ERK1/2 phosphorylation (P-ERK1/2), an effect that was not mimicked by dibutryl-cGMP. Furthermore, CNP-stimulated P-ERK1/2 occurred at concentrations below that required for cGMP accumulation. The effect of CNP on P-ERK1/2 was sensitive to pharmacological blockade of MEK (U0126) and Src kinases (PP2). Silencing of the GC-B1 and GC-B2 splice variants of the GC-B receptor by using targeted short interfering RNAs completely blocked the CNP effects on P-ERK1/2. CNP failed to alter GH3 cell proliferation or cell cycle distribution but caused a concentration-dependent increase in the activity of the human glycoprotein α-subunit promoter (αGSU) in a MEK-dependent manner. Finally, CNP also activated the p38 and JNK MAPK pathways in GH3 cells. These findings reveal an additional mechanism of GC-B signalling and suggest additional biological roles for CNP in its target tissues
Correlation of Thin-Film Bond Compliance and Bond Fracture Resistance
The integrity of the interfacial bond between a coating and its substrate is of primary importance for any application. A technique for the quantitative nondestructive measurement of the bond fracture energy is essential for evaluating bond integrity. Scanning acoustic microscopy (SAM) provides a method for making localized measurements of film dis-bonds and film bond compliance based on the changes in the surface acoustic wave velocity in the layered medium. The results of these measurements for chrome/gold and gold films on glass substrates are summarized. The compliance of the bond and its fracture energy can be correlated in some film systems. An experiment to determine if this correlation exists for chrome/gold and gold films on sapphire substrates is described. Results of such an experiment would provide an empirical correlation between surface acoustic wave velocity measurements and the fracture energy of the film. The results of an experiment to measure the fracture energy of the interfacial bond between a gold film and the sapphire substrate are described.</p
Multifrequency Strategies for the Identification of Gamma-Ray Sources
More than half the sources in the Third EGRET (3EG) catalog have no firmly
established counterparts at other wavelengths and are unidentified. Some of
these unidentified sources have remained a mystery since the first surveys of
the gamma-ray sky with the COS-B satellite. The unidentified sources generally
have large error circles, and finding counterparts has often been a challenging
job. A multiwavelength approach, using X-ray, optical, and radio data, is often
needed to understand the nature of these sources. This chapter reviews the
technique of identification of EGRET sources using multiwavelength studies of
the gamma-ray fields.Comment: 35 pages, 22 figures. Chapter prepared for the book "Cosmic Gamma-ray
Sources", edited by K.S. Cheng and G.E. Romero, to be published by Kluwer
Academic Press, 2004. For complete article and higher resolution figures, go
to: http://www.astro.columbia.edu/~muk/mukherjee_multiwave.pd
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