The University of Alaska Anchorage experience

In the fall 2005, when two faculty librarians at the University of Alaska Anchorage’s (UAA) Consortium Library realized that three people on the library staff were enrolled in library school, they saw the perfect opportunity to start a discussion group that would benefit both currently employed librarians and students entering the information field. The original three students were enrolled in the MLIS distance program at the University of Washington, working in the Consortium Library, and taking classes part-time. The two faculty librarians had been out of library school for more than ten years by then, so the intent was to organize a forum with an informal, relaxed atmosphere that would be an engaging way to keep up with current curricula, to learn about class projects the students were working on, and to hear about their experiences. While the librarians learned from the students, the students could, in turn, share their new expertise with the library faculty. That was the beginning of what came to be known as FLIP: Future Library and Information Science People.1 Now, nearly seven years later, FLIP is still going strong. What the name stands for has changed slightly—to Future Librarians and Information Professionals—and the membership has expanded to include anyone considering a career as a librarian or enrolling in an MLS or MLIS program. Characterizing FLIP as a “mentoring” program misses the mark, since so much more than just mentoring is happening. Because the benefits go both ways, we prefer the term “un-mentoring” to describe FLIP. Regardless of its definition or description, however, the original purpose remains the same: to provide an informal discussion forum that enriches library school studies with librarian expertise, advice, and insight

Unified explanation of the Kadowaki-Woods ratio in strongly correlated materials

Discoveries of ratios whose values are constant within broad classes of materials have led to many deep physical insights. The Kadowaki-Woods ratio (KWR) compares the temperature dependence of a metal's resistivity to that of its heat capacity; thereby probing the relationship between the electron-electron scattering rate and the renormalisation of the electron mass. However, the KWR takes very different values in different materials. Here we introduce a ratio, closely related to the KWR, that includes the effects of carrier density and spatial dimensionality and takes the same (predicted) value in organic charge transfer salts, transition metal oxides, heavy fermions and transition metals - despite the numerator and denominator varying by ten orders of magnitude. Hence, in these materials, the same emergent physics is responsible for the mass enhancement and the quadratic temperature dependence of the resistivity and no exotic explanations of their KWRs are required.Comment: Final version accepted by Nature Phy

A New Optimal Stepsize For Approximate Dynamic Programming

Approximate dynamic programming (ADP) has proven itself in a wide range of applications spanning large-scale transportation problems, health care, revenue management, and energy systems. The design of effective ADP algorithms has many dimensions, but one crucial factor is the stepsize rule used to update a value function approximation. Many operations research applications are computationally intensive, and it is important to obtain good results quickly. Furthermore, the most popular stepsize formulas use tunable parameters and can produce very poor results if tuned improperly. We derive a new stepsize rule that optimizes the prediction error in order to improve the short-term performance of an ADP algorithm. With only one, relatively insensitive tunable parameter, the new rule adapts to the level of noise in the problem and produces faster convergence in numerical experiments.Comment: Matlab files are included with the paper sourc

A Cholecystokinin B Receptor-Specific Aptamer Does Not Activate Receptor Signaling

Targeted nanoparticles which deliver effective doses of chemotherapeutic drugs directly to pancreatic tumors could improve treatment efficacy without the toxicities associated with systemic drug administration. One protein on tumor cells that can be targeted by nanoparticles is a G-protein coupled cell surface receptor, the cholecystokinin B receptor (CCKBR). Previously, we had shown that attaching the CCKBR ligand gastrin to the surface of nanoparticles can enhance their up-take by tumors. The drawback of using gastrin is that it can also activate the receptor, causing tumor cell growth. This study shows that a DNA aptamer that binds to the CCKBR and enhances nanoparticle up-take by tumors does not activate this receptor. PANC-1 cells, a cultured human pancreatic cancer cell line, were treated for 24 h with CCKBR aptamer 1153. Cell lysates were run on Bis-Tris gels, transferred to membranes, blocked in 5% BSA and incubated overnight with primary antibodies, including antibodies directly against phosphorylated-Akt (Ser473), total Akt, and beta-actin, a protein loading control. Although the CCKBR aptamer 1153 is internalized by pancreatic cancer cells in a receptor-mediated fashion, it does not stimulate cell proliferation. Because of this, we anticipate that it will not activate CCKBR signaling. If aptamer 1153 does not activate downstream receptor signaling, our future work will test whether the aptamer could be used to specifically direct drug-containing nanoparticles to tumors, making chemotherapy treatments for pancreatic cancer patients more effective with fewer off-target effects and toxicity