Detecting a rotation in the epsilon Eridani debris disc

The evidence for a rotation of the epsilon Eridani debris disc is examined. Data at 850 micron wavelength were previously obtained using the Submillimetre Common User Bolometer Array (SCUBA) over periods in 1997-1998 and 2000-2002. By chi-square fitting after shift and rotation operations, images from these two epochs were compared to recover proper motion and orbital motion of the disc. The same procedures were then performed on simulated images to estimate the accuracy of the results. Minima in the chi-square plots indicate a motion of the disc of approximately 0.6'' per year in the direction of the star's proper motion. This underestimates the true value of 1'' per year, implying that some of the structure in the disc region is not associated with epsilon Eridani, originating instead from background galaxies. From the chi-square fitting for orbital motion, a counterclockwise rotation rate of ~2.75 degrees per year is deduced. Comparisons with simulated data in which the disc is not rotating show that noise and background galaxies result in approximately Gaussian fluctuations with a standard deviation +/-1.5 degrees per year. Thus counterclockwise rotation of disc features is supported at approximately a 2-sigma level, after a 4-year time difference. This rate is faster than the Keplerian rate of 0.65 degrees per year for features at ~65 AU from the star, suggesting their motion is tracking a planet inside the dust ring. Future observations with SCUBA-2 can rule out no rotation of the epsilon Eridani dust clumps with ~4-sigma confidence. Assuming a rate of about 2.75 degrees per year, the rotation of the features after a 10-year period could be shown to be >1 degree per year at the 3-sigma level.Comment: 8 pages, 6 figure

Priorities and Preconditions for Successful Investment in Smallholder Agriculture in Sub-Saharan Africa

In the past couple of years, there has been resurgence in interest in smallholder agriculture as a potential driver for growth and poverty reduction in Sub-Saharan Africa. However, there remains considerable skepticism as to whether public investment in smallholder agriculture will lead to the desired growth and poverty reduction, given a general pessimism about "absorptive capacity" for (public) investment in Africa, the perception of failure of past agricultural investment and the observation that current conditions are unconducive to agricultural growth in Africa. This paper combines experiences of two UK-based NGOs dedicated to promoting smallholder agriculture and strengthening rural livelihoods in Africa with insights from academic literature on African agriculture and rural markets to set out an agenda for investment in smallholder agriculture in Africa. It identifies priorities for public investment, but also key issues related to "absorptive capacity" that need to be addressed if such investment is to succeed in generating agricultural growth and poverty reduction. Particular emphasis is placed on: a) investment in human and organisational capacity of smallholder farmers; b) investment in coordinated service provision to equip producers to respond to evolving market opportunities; c) the process of developing and implementing credible agricultural development strategies at both national and local level, and; d) reform of Ministries of Agriculture to support this process.International Development,

FES rehabilitation platform with real-time control and performance feedback.

Osteoporosis after spinal cord injury is associated with low-trauma fractures, and consequently with increased risk of morbidity and mortality. The loss of bone mass density (BMD) due to paraplegia can be reduced through cyclical electrically-induced muscle contractions. Here we propose an FES control system based on posture switching, that induces transient loading of the lower limbs during a set of standing postures. This aims to produce an increased, evenly distributed BMD, whilst minimising FES-induced muscle fatigue. Here we describe the design and assessment of the FES exercising platform, comprising a controllable multi-channel electrical stimulator and an instrumented standing frame. The platform supports standing and postural shifting, provides real-time human-in-the-loop FES control with on-line feedback to the user. The platforms is used to investigate the effect of regular exercise on the distribution of BMD in people with paraplegia

Centrosomes are multifunctional regulators of genome stability

The maintenance of genome stability is critical for proper cell function, and loss of this stability contributes to many human diseases and developmental disorders. Therefore, cells have evolved partially redundant mechanisms to monitor and protect the genome. One subcellular organelle implicated in the maintenance of genome stability is the centrosome, best known as the primary microtubule organizing center of most animal cells. Centrosomes serve many different roles throughout the cell cycle, and many of those roles, including mitotic spindle assembly, nucleation of the interphase microtubule array, DNA damage response, and efficient cell cycle progression, have been proposed to help maintain genome stability. As a result, the centrosome is itself a highly regulated entity. Here, we review evidence concerning the significance of the centrosome in promoting genome integrity. Recent advances permitting acute and persistent centrosome removal suggest we still have much to learn regarding the specific function and actual importance of centrosomes in different contexts, as well as how cells may compensate for centrosome dysfunction to maintain the integrity of the genome. Although many animal cells survive and proliferate in the absence of centrosomes, they do so aberrantly. Based on these and other studies, we conclude that centrosomes serve as critical, multifunctional organelles that promote genome stability