S.O.S.

The concept that type 2 diabetes mellitus (T2DM) can be reversed with an intestinal operation is counterintuitive. How could our costliest disease be forced into full, durable, and safe remission with the bypass of a few inches of intestine? Counterintuitive or not, it’s true. Accordingly, we take notice when Sjöström and colleagues (1) in the Swedish Obese Subjects (SOS) study, the longest and most complete bariatric surgery outcome study in the world, document in this issue that bariatric surgery reduces the incidence of heart attacks. The SOS is a prospective, nonrandomized, controlled interventional trial on the effect of bariatric surgery on mortality and morbidity compared with conventional treatment that enrolled 4,047 obese individuals from 1 September 1987 to 31 January 2001. Of these, 2,010 underwent bariatric surgery, and a contemporary matched group of 2,037 did not. The current report compared the 345 diabetic patients who underwent bariatric surgery with the 262 who did not. The authors found that “bariatric surgery was associated with a reduced myocardial infarction incidence� (38/345 [11.0%] in the surgery vs. control group 43/262 [16.4%] [P = 0.017]). The effect was stronger in individuals with higher serum cholesterol and triglycerides at baseline. Not surprising, since the bariatric surgery was associated with significant decreases in body weight, blood glucose, serum triglycerides, systolic and diastolic blood pressure, and an increase in HDL-cholesterol

Hair radioactivity as a measure of exposure to radioisotopes

Since many radioisotopes accumulate in hair, this tropism was investigated by comparing the radioactivity of shaved with plucked hair collected from rats at various time intervals up to 24 hrs after intravenous injection of the ecologically important radioisotopes, iodine-131, manganese-54, strontium-85, and zinc-65. The plucked hair includes the hair follicles where biochemical transformations are taking place. The data indicate a slight surge of each radioisotpe into the hair immediately after injection, a variation of content of each radionuclide in the hair, and a greater accumulation of radioactivity in plucked than in shaved hair. These results have application not only to hair as a measure of exposure to radioisotopes, but also to tissue damage and repair at the hair follicle

Factors Influencing the Consumer Adoption of Mobile QR Code Payments in Indonesian University Students

Abstract . Financial Technology (Fintech) was known to disrupt the financial sector. Fintech ecosystem were mapped by fintechnews.sg (2018) by 9 categories, and payment technology had the biggest distribution with mobile phone as part of this technology. Hootsuite (2019) stated that 60% of Indonesian adult population used smartphone, which explained the rapid growth of smartphone. With common technology of mobile phone camera, QR Code Payment arisen as a prominent mobile payment method. 1005 Indonesian University Students were made as respondents, considering that Ameme (2015)’s explanation that younger people’s technology adoption was bigger than the older ones. This research was purposed to examine the digital savviness of Indonesian University Students, using ratings of six group of activities that considered to be a basic necessities, based on Maslow (1943) and Deci and Ryan (2000). It was known that respondents had average index of “3.02”, and differences of index average happened on groups of sex and monthly income. In addition, current QR code payment adoption were analysed, where 78.91% respondents adopted QR Code Payment, mostly used Go – Pay and most of adopters had purchased food and beverage. Average digital lifestyle index were homogeneous among adopters and non – adopters. In addition, adoption factors were also analysed with UTAUT model, where several factors were known to had a significant influence toward the intention to adopt QR Code Payment, which were Cost (negative), Performance Expectancy (positive), Effort Expectancy (positive) and Social Influence (positive). Involvement was known to played moderation role on PE and SI’s impact toward the intention to adopt.Keywords: UTAUT, QR Code Payment, Cost, Digital Lifestyle Index, Indonesia, University Students

Outcomes of Roux-en-Y gastric bypass surgery for severely obese patients with type 1 diabetes: a case series report

Roux-en-Y gastric bypass surgery (RYGB) reverses type 2 diabetes (DM2) in approximately 83% of patients with morbid or severe obesity. This procedure has been performed in small numbers of severely obese patients with type 1 diabetes (DM1), but the impact on glycemic control and insulin requirement in this population has not been widely described. We report three patients with DM1 and severe obesity that underwent RYGB. Weight, glycemic control, and insulin requirements before and one year after the procedure were compared. Significant weight loss was achieved by all three patients but insulin requirements decreased in only 2 patients. In contrast, glycemic control (A1C) remained suboptimal in all three patients up to one year after the surgery. These findings suggest that RYGB leads to important weight loss and positively affects insulin sensitivity. However, reaching optimal glycemic control in patients with DM1 diabetes remains challenging due to persisting insulin deficiency

Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals?

Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are retained in human skeletal muscle cells raised in culture. Together, these findings are indicative of a dysfunctional global metabolic program with severe obesity which is of an epigenetic or genetic origin. Weight loss via gastric bypass surgery can “turn off” and/or correct components of this metabolic program as insulin sensitivity is restored; however, the impairment in FAO in skeletal muscle remains evident. Physical activity can improve FAO and insulin action, indicating that this patient population is not exercise resistant and that exercise offers a pathway to circumvent the abnormal program. Findings presented in this review will hopefully increase the understanding of and aid in preventing and/or treating the severely obese condition