1 research outputs found
Predictive value of risk factors for periodontitis and assessment criteria of the flow of inflammation in periodontitis on the basis of molecular genetic tests
The article analyzes the predictive value of risk factors for periodontitis, the data obtained from a prospective observation of 150 patients. Evaluation of the flow of the process of inflammation was carried out according to morphological study. Saving inflammatory infiltrate in the background of the anti-microbial treatment stage, accompanied by marked clinical effect was regarded as 'poor' outcome of therapy. Discriminant analysis of anamnestic, clinical, morphological and molecular genetic characteristics of patients allowed to calculate graduation factors predicting. The greatest predictive value is a predictor of 'carrier 2R allele of the gene IL-1 RN, IL-1 family1. Following graduation in molecular genetics predictor is β3R allele of the gene IL-4 and the last one -'allele-308A' gene TNFΞ±Β». Of the predictors of having a digital expression, the greatest predictive value are: the 'age' and 'Limitation of the diseaseβ. This combination of predictors can provide the level of correct prediction in 79.8%.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ³Π½ΠΎΠ·Π½ΠΎΠΉ ΡΠ΅Π½Π½ΠΎΡΡΠΈ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ° ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΈΡΠ°, Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ 150 Π±ΠΎΠ»ΡΠ½ΡΡ
. ΠΡΠ΅Π½ΠΊΠ° Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. Π‘ΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠ΅ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠΈΠ»ΡΡΡΠ°ΡΠ° Π½Π° ΡΠΎΠ½Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΡΠ°ΠΏΠ° Π»Π΅ΡΠ΅Π½ΠΈΡ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π²ΡΠ΅Π³ΠΎΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΡΡΠ΅ΠΊΡΠΎΠΌ, ΡΠ°ΡΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΊΠ°ΠΊ Β«Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΉΒ» ΠΈΡΡ
ΠΎΠ΄ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠΈΡΠΊΡΠΈΠΌΠΈΠ½Π°Π½ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
, ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» ΡΠ°ΡΡΡΠΈΡΠ°ΡΡ Π³ΡΠ°Π΄Π°ΡΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΡΡ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π½ΡΡ ΡΠ΅Π½Π½ΠΎΡΡΡ ΠΈΠΌΠ΅Π΅Ρ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡ Β«Π½ΠΎΡΠΈΡΠ΅Π»ΡΡΡΠ²ΠΎ Π°Π»Π»Π΅Π»Ρ 2R Π³Π΅Π½Π° IL-1RN, ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° IL-1Β». Π‘Π»Π΅Π΄ΡΡΡΠΈΠΌΠΈ ΠΏΠΎ Π³ΡΠ°Π΄Π°ΡΠΈΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠΎΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ Β«Π°Π»Π»Π΅Π»Ρ 3R Π³Π΅Π½Π° IL-4Β» ΠΈ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠΌ - Β«Π°Π»Π»Π΅Π»Ρ -308Π* Π³Π΅Π½Π° TNFΞ±Β». ΠΠ· ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠΎΠ², ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΠΈΡΡΠΎΠ²ΠΎΠ΅ Π²ΡΡΠ°ΠΆΠ΅Π½ΠΈΠ΅, Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΡΡ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π½ΡΡ ΡΠ΅Π½Π½ΠΎΡΡΡ ΠΈΠΌΠ΅ΡΡ: Β«Π²ΠΎΠ·ΡΠ°ΡΡΒ» ΠΈ Β«Π΄Π°Π²Π½ΠΎΡΡΡ Π±ΠΎΠ»Π΅Π·Π½ΠΈΒ». ΠΠ°Π½Π½ΠΎΠ΅ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π° Π² 79,8%