Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches

Trial-based economic evaluations are an important aspect of health technology assessment. The availability of patient-level data coupled with unbiased estimates of clinical outcomes means that randomised controlled trials are effective vehicles for the generation of economic data. However there are methodological challenges to trial-based evaluations, which include the collection of reliable data on resource use and cost, choice of health outcome measure, calculating minimally important differences, dealing with missing data, extrapolating outcomes and costs over time and the analysis of multinational trials. This review focuses on the state of the art of selective elements concerning the design, conduct, analysis and reporting of trial-based economic evaluations. The limitations of existing approaches are detailed and novel methods introduced. The review is internationally relevant but with a focus towards practice in the UK

Year in review in Intensive Care Medicine 2010: III. ARDS and ALI, mechanical ventilation, noninvasive ventilation, weaning, endotracheal intubation, lung ultrasound and paediatrics

SCOPUS: re.jinfo:eu-repo/semantics/publishe

A course of mathematics for engineers and scientists: theoretical mechanics

A Course of Mathematics for Engineers and Scientist

A course of mathematics for engineerings and scientists

A Course of Mathematics for Engineers and Scientists, Volume 2 continues the course of pure and applied mathematics for undergraduate science and engineering students. It contains further examples and exercises from examination papers from Oxford University, Cambridge University, and the University of London. The topics covered in this book include differential equations, linear equations, matrices and determinants, vector algebra and coordinate geometry, and differentiation and integration of functions of two or more variables. This book is intended as a reference for students taking scienc

Probability logic and conversation

The Conversational Hypothesis is examined and it is suggested that a primary application of this hypothesis is to solve the problem of indicative conditionals. It is argued that this application fails, and the extent of this failure is documented. The problem is that the Conversational Hypothesis is predicated upon a notion of truth, and conditionals are not truth-bearing objects. A probability alternative is sketched and its advantages underscored. The alternative, while not problem-free, is shown to have conceptual and theoretical strengths which recommend its adoption over the truth-based paradigm