Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia : results of the EORTC CLG 58881 and 58951 trials

info:eu-repo/semantics/publishe

Quality of life of long-term childhood acute lymphoblastic leukemia survivors:Comparison with healthy controls

peer reviewed[en] OBJECTIVE: Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long-term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long-term QoL outcomes of survivors of childhood ALL compared to matched population controls. METHODS: QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF-12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF-12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive. RESULTS: One hundred and eighty-six survivors (mean age: 27.6 years; range: 18.1-52.8) at follow-up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self-esteem, Nutrition and Paid Work. CONCLUSIONS: Our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners

Optimisation du traitement biologique aérobie des effluents vinicoles

The aerobic biologic treatment of wine-effluents is often realized by extensive way. In these circumstances, the effluent can be released in the sewage system (BOD less than 500 mg o2/l) after 4 to 5 weeks of treatment. The aim of this experimentation is to intensify the biologic phenomena in order to reduce the time treatment. Many parameters open to improve the treatment have been tested in micro-sewage treatment. The parameters involved was the pH, the temperature, the aeration (physicochemical parameters,) and some biological parameters (yeasts, bacteria, sludge from wine wastewater plant). The observation of COD decreasing shown some interesting parameters. The addition of nitrogen and phosphorus, the temperature and the seeding with sludge from wine wastewater plant are important parameters in the researchway of optimization. / Le traitement biologique aérobie des effluents vinicoles est souvent réalisé de manière extensive par batch. Dans ces conditions, l'effluent devient rejetable dans le réseau d'assainissement (DBO5 inférieure à 500 mg 02/l) qu'après quatre ou cinq semaines de traitement. Cette expérimentation a pour objectif d'intensifier les phénomènes biologiques afin de réduire le temps de traitement. Des micro-épurations ont permis de tester plusieurs facteurs susceptibles d'améliorer le traitement. Ces facteurs étaient de nature physico-chimique (pH, température, aération) et de nature biologique (levure, bactéries, boues de station d'épuration, boues d'origine vinicole). Le suivi de la dégradation de la DCO, par rapport à un témoin a permis de dégager les facteurs intéressants. La complémentation en azote et phosphore, la température et l'ensemencement avec de la biomasse adaptée aux effluents vinicoles sont des paramètres importants dans cette recherche d'optimisation

Une masse indolente et fluctuante sous-cutanée du crâne chez une patiente de 5 ans : démarche et difficultés diagnostiques

International audienc

De la pédiatrie à la médecine adulte : transition des patients drépanocytaires, une étude monocentrique française

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"Frameworks for Research Integration: A Cross-Disciplinary Dialogue", China Media Research, 13(3), pp. 7-16.

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