2,085 research outputs found
Gene Transcription Changes in Asthmatic Chronic Rhinosinusitis with Nasal Polyps and Comparison to Those in Atopic Dermatitis
Asthmatic chronic rhinosinusitis with nasal polyps (aCRSwNP) is a common disruptive eosinophilic disease without effective medical treatment. Therefore, we sought to identify gene expression changes, particularly those occurring early, in aCRSwNP. To highlight expression changes associated with eosinophilic epithelial inflammation, we further compared the changes in aCRSwNP with those in a second eosinophilic epithelial disease, atopic dermatitis (AD), which is also closely related to asthma.Genome-wide mRNA levels measured by exon array in both nasosinus inflamed mucosa and adjacent polyp from 11 aCRSwNP patients were compared to those in nasosinus tissue from 17 normal or rhinitis subjects without polyps. Differential expression of selected genes was confirmed by qRT-PCR or immunoassay, and transcription changes common to AD were identified. Comparison of aCRSwNP inflamed mucosa and polyp to normal/rhinitis tissue identified 447 differentially transcribed genes at > or = 2 fold-change and adjusted p-value < 0.05. These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased IL1RL1 (IL33 receptor) and EMR1&3 and decreased CRISP2&3. A down-regulated PDGFB-centric network involving several smooth muscle-associated genes was also implicated. Genes at 17q11.2, genes associated with alternative activation or smooth muscle, and the IL1RL1 gene were also differentially transcribed in AD.Our data implicate several genes or gene sets in aCRSwNP and eosinophilic epithelial inflammation, some that likely act in the earlier stages of inflammation. The identified gene expression changes provide additional diagnostic and therapeutic targets for aCRSwNP and other eosinophilic epithelial diseases
Improved Measurement of the Form Factors in the Decay Lambda_c^+ --> Lambda e^+ nu_e
Using the CLEO detector at the Cornell Electron Storage Ring, we have studied
the distribution of kinematic variables in the decay Lambda_c^+ -> Lambda e^+
nu_e. By performing a four-dimensional maximum likelihood fit, we determine the
form factor ratio, R = f_2/f_1 = -0.31 +/- 0.05(stat) +/- 0.04(syst), the pole
mass, M_{pole} = (2.21 +/- 0.08(stat) +/- 0.14(syst)) GeV/c^2, and the decay
asymmetry parameter of the Lambda_c, alpha_{Lambda_c} = -0.86 +/- 0.03(stat)
+/- 0.02(syst), for = 0.67 (GeV/c^2)^2. We compare the angular
distributions of the Lambda_c^+ and Lambda_c^- and find no evidence for
CP-violation: A_{Lambda_c} = (alpha_{Lambda_c^+} + alpha_{Lambda_c^-})/
(alpha_{Lambda_c^+} - alpha_{Lambda_c^-}) = 0.00 +/- 0.03(stat) +/- 0.01(syst)
+/- 0.02, where the third error is from the uncertainty in the world average of
the CP-violating parameter, A_{Lambda}, for Lambda -> p pi^-.Comment: 8 pages postscript,also available through
http://www.lns.cornell.edu/public/CLNS/2004/, submitted to PR
Observation of the Hadronic Transitions Chi_{b 1,2}(2P) -> omega Upsilon(1S)
The CLEO Collaboration has observed the first hadronic transition among
bottomonium (b bbar) states other than the dipion transitions among vector
states, Upsilon(nS) -> pi pi Upsilon(mS). In our study of Upsilon(3S) decays,
we find a significant signal for Upsilon(3S) -> gamma omega Upsilon(1S) that is
consistent with radiative decays Upsilon(3S) -> gamma chi_{b 1,2}(2P), followed
by chi_{b 1,2} -> omega Upsilon(1S). The branching ratios we obtain are
Br(chi_{b1} -> omega Upsilon(1S) = 1.63 (+0.35 -0.31) (+0.16 -0.15) % and
Br(chi_{b2} -> omega Upsilon(1S) = 1.10 (+0.32 -0.28) (+0.11 - 0.10)%, in which
the first error is statistical and the second is systematic.Comment: submitted to XXI Intern'l Symp on Lepton and Photon Interact'ns at
High Energies, August 2003, Fermila
Branching Fractions of tau Leptons to Three Charged Hadrons
From electron-positron collision data collected with the CLEO detector
operating at CESR near \sqrt{s}=10.6 GeV, improved measurements of the
branching fractions for tau decays into three explicitly identified hadrons and
a neutrino are presented as {\cal
B}(\tau^-\to\pi^-\pi^+\pi^-\nu_\tau)=(9.13\pm0.05\pm0.46)%, {\cal B}(\tau^-\to
K^-\pi^+\pi^-\nu_\tau)=(3.84\pm0.14\pm0.38)\times10^{-3}, {\cal B}(\tau^-\to
K^-K^+\pi^-\nu_\tau)=(1.55\pm0.06\pm0.09)\times10^{-3}, and {\cal B}(\tau^-\to
K^-K^+K^-\nu_\tau)<3.7\times10^{-5} at 90% C.L., where the uncertainties are
statistical and systematic, respectively.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, to appear in Phys. Rev. Let
Anti-Search for the Glueball Candidate f_J(2220) in Two-Photon Interactions
Using 13.3 fb^{-1} of e^+e^- data recorded with the CLEO II and CLEO II.V
detector configurations at CESR, we have searched for f_J(2220) decays to
K^0_{S} K^0_{S} in untagged two-photon interactions. We report an upper limit
on the product of the two-photon partial width and the branching fraction,
Gamma_gamma gamma cdot B (f_J(2220) to K^0_{S} K^0_{S}) of less than 1.1 eV at
the 95% C.L: systematic uncertainties are included. This dataset is four times
larger than that used in the previous CLEO publication.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, Submitted to PRD (R
Search for CP Violation in D^0--> K_S^0 pi^+pi^-
We report on a search for CP violation in the decay of D0 and D0B to Kshort
pi+pi-. The data come from an integrated luminosity of 9.0 1/fb of e+e-
collisions at sqrt(s) ~ 10 GeV recorded with the CLEO II.V detector. The
resonance substructure of this decay is well described by ten quasi-two-body
decay channels (K*-pi+, K*0(1430)-pi+, K*2(1430)-pi+, K*(1680)-pi+, Kshort rho,
Kshort omega, Kshort f0(980), Kshort f2(1270), Kshort f0(1370), and the ``wrong
sign'' K*+ pi-) plus a small non-resonant component. We observe no evidence for
CP violation in the amplitudes and phases that describe the decay D0 to K_S^0
pi+pi-.Comment: 10 pages, 3 figures, also available at
http://w4.lns.cornell.edu/public/CLNS/, submitted to PR
Observation of a Narrow Resonance of Mass 2.46 GeV/c^2 Decaying to D_s^*+ pi^0 and Confirmation of the D_sJ^* (2317) State
Using 13.5 inverse fb of e+e- annihilation data collected with the CLEO II
detector we have observed a narrow resonance in the Ds*+pi0 final state, with a
mass near 2.46 GeV. The search for such a state was motivated by the recent
discovery by the BaBar Collaboration of a narrow state at 2.32 GeV, the
DsJ*(2317)+ that decays to Ds+pi0. Reconstructing the Ds+pi0 and Ds*+pi0 final
states in CLEO data, we observe peaks in both of the corresponding
reconstructed mass difference distributions, dM(Dspi0)=M(Dspi0)-M(Ds) and
dM(Ds*pi0)=M(Ds*pi0)-M(Ds*), both of them at values near 350 MeV. We interpret
these peaks as signatures of two distinct states, the DsJ*(2317)+ plus a new
state, designated as the DsJ(2463)+. Because of the similar dM values, each of
these states represents a source of background for the other if photons are
lost, ignored or added. A quantitative accounting of these reflections confirms
that both states exist. We have measured the mean mass differences
= 350.0 +/- 1.2 [stat] +/- 1.0 [syst] MeV for the DsJ*(2317) state, and
= 351.2 +/- 1.7 [stat] +/- 1.0 [syst] MeV for the new DsJ(2463)+
state. We have also searched, but find no evidence, for decays of the two
states via the channels Ds*+gamma, Ds+gamma, and Ds+pi+pi-. The observations of
the two states at 2.32 and 2.46 GeV, in the Ds+pi0 and Ds*+pi0 decay channels
respectively, are consistent with their interpretations as (c anti-strange)
mesons with orbital angular momentum L=1, and spin-parities of 0+ and 1+.Comment: 16 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, version to be published in Physical
Review D; minor modifications and fixes to typographical errors, plus an
added section on production properties. The main results are unchanged; they
supersede those reported in hep-ex/030501
Further Experimental Studies of Two-Body Radiative \Upsilon Decays
Continuing our studies of radiative Upsilon(1S) decays, we report on a search
for Upsilon to gamma eta and Upsilon to gamma f_{J}(2220) in 61.3 pb^{-1} of
e^{+}e^{-} data taken with the CLEO II detector at the Cornell Electron Storage
Ring. For the gamma eta search the three decays of the eta meson to
pi^{+}pi^{-}pi^{0}, pi^{0}pi^{0}pi^{0}, and gamma gamma were investigated. We
found no candidate events in the two (3\pi)^{0} modes and no significant excess
over expected backgrounds in the gamma gamma mode to set a limit on the
branching fraction of B(Upsilon to gamma eta) < 2.1 x 10^{-5} at 90% C.L. The
three charged two-body final states h h-bar (h = pi^{+}, K^{+}, p) were
investigated for f_{J}(2220) production, with one, one, and two events found,
respectively. Limits at 90% C.L. of B(\Upsilon to gamma f_{J}) x B(f_{J} to h
h-bar) ~ 1.5 x 10^{-5} have been set for each of these modes. We compare our
results to measurements of other radiative Upsilon decays, to measurements of
radiative J/psi decays, and to theoretical predictions.Comment: 19 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, submitted to Physical Review
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