10 research outputs found

    Tracing Back the Eighteenth Century "Nuptiality Transition" in Finland

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    Official Finnish population statistics starting in 1751 do not provide cross-classifications of age and marital status before 1880. However, declining overall proportions married and declining fertility rates suggest a major change in the marriage pattern during the second half of the eighteenth century. Five sources of information, namely overall proportions married, annual numbers of marriages, sizes of marriage cohorts relative to mortality-adjusted birth cohorts, information on the modal age at marriage from lagged correlation analysis between sizes of birth and marriage cohorts, and trends in age-specific fertility are analyzed to provide information on nuptiality trends. A simulation model based on the Coale-McNeill marriage model yields parameter estimates for the Finnish provinces in 1751-1772, which allow calculation of the "Princeton Index" I_m. The results suggest a "nuptiality transition" from early and almost universal marriage to the so-called "European Marriage Pattern", which is characterized by late marriage and high proportions of unmarried. Provincial level analysis reveals significant east-west differentials with higher proportions marrying and lower mean ages at marriage in the eastern parts of Finland. Non-quantitative historical evidence in general also supports the assumption of a major change in the Finnish nuptiality pattern during the second half of the eighteenth century

    Highlights From the Annual Meeting of the American Epilepsy Society 2022

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    With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health professionals gathered to learn a variety of topics about epilepsy. The program was carefully tailored to meet the needs of professionals with different interests and career stages. This article summarizes the different symposia presented at the meeting. Basic science lectures addressed the primary elements of seizure generation and pathophysiology of epilepsy in different disease states. Scientists congregated to learn about anti-seizure medications, mechanisms of action, and new tools to treat epilepsy including surgery and neurostimulation. Some symposia were also dedicated to discuss epilepsy comorbidities and practical issues regarding epilepsy care. An increasing number of patient advocates discussing their stories were intertwined within scientific activities. Many smaller group sessions targeted more specific topics to encourage member participation, including Special Interest Groups, Investigator, and Skills Workshops. Special lectures included the renown Hoyer and Lombroso, an ILAE/IBE joint session, a spotlight on the impact of Dobbs v. Jackson on reproductive health in epilepsy, and a joint session with the NAEC on coding and reimbursement policies. The hot topics symposium was focused on traumatic brain injury and post-traumatic epilepsy. A balanced collaboration with the industry allowed presentations of the latest pharmaceutical and engineering advances in satellite symposia

    α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Antagonists: From Bench to Bedside

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    Highlights From the Annual Meeting of the American Epilepsy Society 2022

    Full text link
    With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health professionals gathered to learn a variety of topics about epilepsy. The program was carefully tailored to meet the needs of professionals with different interests and career stages. This article summarizes the different symposia presented at the meeting. Basic science lectures addressed the primary elements of seizure generation and pathophysiology of epilepsy in different disease states. Scientists congregated to learn about anti-seizure medications, mechanisms of action, and new tools to treat epilepsy including surgery and neurostimulation. Some symposia were also dedicated to discuss epilepsy comorbidities and practical issues regarding epilepsy care. An increasing number of patient advocates discussing their stories were intertwined within scientific activities.Many smaller group sessions targeted more specific topics to encourage member participation, including Special Interest Groups, Investigator, and Skills Workshops. Special lectures included the renown Hoyer and Lombroso, an ILAE/IBE joint session, a spotlight on the impact of Dobbs v. Jackson on reproductive health in epilepsy, and a joint session with the NAEC on coding and reimbursement policies. The hot topics symposium was focused on traumatic brain injury and post-traumatic epilepsy.A balanced collaboration with the industry allowed presentations of the latest pharmaceutical and engineering advances in satellite symposia.</jats:p

    Pan-cancer analysis of whole genomes

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