La formación docente en momentos de cambios: ¿Qué nos dicen los profesores principiantes universiatrios?

Este estudio cualitativo con una metodología de estudios de casos múltiple examina la opinión de los profesores principiantes de la Universidad de Barcelona sobre las consecuencias del proceso de implementación del Espacio Europeo de Educación Superior (EEES). Indaga sobre la valoración que realiza el profesorado sobre la formación recibida en el postgrado de 'Iniciación a la docencia universitaria' y sobre los aprendizajes que les generó la experiencia formativa. La muestra de la investigación ha estado constituida por diez profesores principiantes de diferentes ámbitos de conocimiento de la Universidad de Barcelona y los datos proceden de la realización de entrevistas en profundidad. Entre los hallazgos más importantes, cabe destacar su percepción sobre la implementación del EEES y las propuestas que dan sobre los cambios que debería realizar la Universidad para una verdadera reforma de la formación de los docente

Peptide-Based Glioma-Targeted Drug Delivery Vector gHoPe2

Gliomas are therapeutically challenging cancers with poor patient prognosis. New drug delivery strategies are needed to achieve a more efficient chemotherapy-based approach against brain tumors. The current paper demonstrates development of a tumor-targeted delivery vector that is based on a cell-penetrating peptide pVEC and a novel glioma-targeting peptide sequence gHo. The unique tumor-homing peptide gHo was identified using <i>in vitro</i> phage display technology. The novel delivery vector, which we designated as gHoPe2, was constructed by a covalent conjugation of pVEC, gHo, and a cargo; the latter could be either a labeling moiety (such as a fluorescent marker) or a cytostatic entity. Using a fluorescent marker, we demonstrate efficient uptake of the vector in glioma cells and selective labeling of glioma xenograft tumors in a mouse model. This is the first time that we know where <i>in vitro</i> phage display has yielded an efficient, <i>in vivo</i> working vector. We also demonstrate antitumor efficacy of the delivery vector gHoPe2 using a well-characterized chemotherapeutic drug doxorubicin. Vectorized doxorubicin proved to be more efficient than the free drug in a mouse glioma xenograft model after systemic administration of the drugs. In conclusion, we have characterized a novel glioma-homing peptide gHo, demonstrated development of a new and potential glioma-targeted drug delivery vector gHoPe2, and demonstrated the general feasibility of the current approach for constructing cell-penetrating peptide-based targeted delivery systems

Additional file 1 of Radiosynthesis, structural identification and in vitro tissue binding study of [18F]FNA-S-ACooP, a novel radiopeptide for targeted PET imaging of fatty acid binding protein 3

Additional file 1. Supplementary experimental data including NMR and MS spectra, HPLC chromatograms of in vitro plasma stability studies etc