Rippling Waters

https://digitalcommons.library.umaine.edu/mmb-ps/1623/thumbnail.jp

Love Me Lots And Love Me All The Time : Song

https://digitalcommons.library.umaine.edu/mmb-vp/5800/thumbnail.jp

Salute The Flag : March and Two Step

https://digitalcommons.library.umaine.edu/mmb-ps/2482/thumbnail.jp

Transitory and Resilient Salient Issues in Party Manifestos, Finland, 1880s to 2010s : Content Analysis by Means of Topic Modeling

Peer reviewe

Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq

A comprehensive analysis of both the molecular genetic and phenotypic responses of any organism to the space flight environment has never been accomplished because of significant technological and logistical hurdles. Moreover, the effects of space flight on microbial pathogenicity and associated infectious disease risks have not been studied. The bacterial pathogen Salmonella typhimurium was grown aboard Space Shuttle mission STS-115 and compared with identical ground control cultures. Global microarray and proteomic analyses revealed that 167 transcripts and 73 proteins changed expression with the conserved RNA-binding protein Hfq identified as a likely global regulator involved in the response to this environment. Hfq involvement was confirmed with a ground-based microgravity culture model. Space flight samples exhibited enhanced virulence in a murine infection model and extracellular matrix accumulation consistent with a biofilm. Strategies to target Hfq and related regulators could potentially decrease infectious disease risks during space flight missions and provide novel therapeutic options on Earth

Öffentliche Meinung und "Policy Feedback"

Dieser Beitrag diskutiert das wechselseitige Verhältnis von öffentlicher Meinung und Sozialpolitik. Der Rolle der öffentlichen Meinung ist in jüngerer Zeit große Aufmerksamkeit zugekommen aufgrund ihres Einflusses auf sozialpolitisches Handeln politischer Parteien. Wir zeigen in diesem Beitrag unterschiedliche empirische und normative Perspektiven auf, die sich mit dieser Frage beschäftigen. Im zweiten Teil diskutieren wir, wie über Policy Feedback-Prozesse die öffentliche Meinung selbst von bestehenden Policies und Institutionen beeinflusst wird