Technique for Arthroscopic-Assisted Primary Anterior Cruciate Ligament Reconstruction Using Doubled Tibialis Anterior Tendon

Advances in surgical technique and our knowledge of anterior cruciate ligament (ACL) anatomy have resulted in a marked increase in options for ACL reconstruction. Currently, patient age and activity level, surgeon preference and experience, and cost are factors influencing the type of reconstruction recommended to address knee instability. We present a simplified transtibial method of ACL reconstruction using a single-bundle, doubled tibialis anterior allograft. This method uses fixation with a suspensory device on the femur and a bio-composite interference screw on the tibia. We recommend this simplified technique for primary ACL reconstruction because it minimizes total steps, thus limiting variance, maximizing efficiency, and reducing potential technical error

The cannabis youth treatment (cyt) study: Main findings from two randomized trials

Abstract This article presents the main outcome findings from two inter-related randomized trials conducted at four sites to evaluate the effectiveness and cost-effectiveness of five short-term outpatient interventions for adolescents with cannabis use disorders. Trial 1 compared five sessions of Motivational Enhancement Therapy plus Cognitive Behavioral Therapy (MET/CBT) with a 12-session regimen of MET and CBT (MET/CBT12) and another that included family education and therapy components (Family Support Network [FSN]). Trial II compared the five-session MET/CBT with the Adolescent Community Reinforcement Approach (ACRA) and Multidimensional Family Therapy (MDFT). The 600 cannabis users were predominately white males, aged 15-16. All five CYT interventions demonstrated significant pre-post treatment improvements during the 12 months after random assignment to a treatment intervention in the two main outcomes: days of abstinence and the percent of adolescents in recovery (no use or abuse/dependence problems and living in the community). Overall, the clinical outcomes were very similar across sites and conditions; however, after controlling for initial severity, the most cost-effective interventions were MET/CBT5 and MET/CBT12 in Trial 1 and ACRA and MET/CBT5 in Trial 2. It is possible that the similar results occurred because outcomes were driven more by general factors beyond the treatment approaches tested in this study; or because of shared, general helping factors across therapies that helped these teens attend to and decrease their connection to cannabis and alcohol.

Whole-exome sequencing and clinical interpretation of FFPE tumor samples to guide precision cancer medicine Whole-exome sequencing and clinical interpretation of FFPE tumor samples to guide precision cancer medicine Corresponding Authors

. "Whole-exome sequencing and clinical interpretation of FFPE tumor samples to guide precision cancer medicine." Nature medicine 20 Disclosures: Dr. Garraway and Dr. Wagle are equity holders and consultants in Foundation Medicine. Dr. Garraway is a consultant to Novartis, Millenium/Takeda, and Boehringer Ingelheim, and a recipient of a grant from Novartis. Dr. Getz is a consultant to The Kew Group. Dr. Barbie is a consultant to N-of-1. NIH Public Acces

Bibliographic processes and products, and a bibliography of the published primary-source works of B. F. Skinner

This paper introduces the nature and practice of bibliography (e.g., definition, history, and genres); it reviews the extant B. F. Skinner bibliographies (1958 to 2001); and it describes the methods used in constructing a new, comprehensive, and corrected bibliography of Skinner's primary-source published works. The bibliography includes 291 items from across 16 categories of publications (e.g., books, articles, chapters, monographs, book reviews, manuals, encyclopedia entries, letters to the editor) and lists them in chronological order (1930 to 1999). A discussion section addresses the bibliography's limitations, how it might be enlarged and expanded, its value for qualitative and quantitative historical inquiry, and the beginnings of a “Skinner industry.