9,471 research outputs found

    Lesson Plan For Teaching Flannery O\u27Connor\u27s A Good Man Is Hard To Find

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    Suitable for high school and college and university classes. Developed by a Swarthmore College student, Adriana Obiols Roca, with feedback from Professor Peter Schmidt, as a final assignment in English 71D, The Short Story in the U.S., spring 2014. Learning Objectives. Students will: understand the differences between direct and indirect characterization and be able to identify examples of each; understand the uses of irony and foreshadowing in the story as well as more generally in literature; become acquainted with Flannery O’Connor and her writing style, particularly with her use of the grotesque; explore the complexity of the themes present in the story and the characters O’Connor has created, especially the Misfit and the grandmother; exercise a variety of critical thinking and analytical skills in order to form ideas and opinions about O\u27Connor\u27s story and her writing strategies; practice reading comprehension and summarization; employ and practice writing skills in an essay assignment

    Identifying Free-Riding in Energy-Conservation Programs Using Revealed Preference Data

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    Identifying the incidence of free-ridership is significant to a range of issues relevant to program evaluation, including the calculation of net program benefits and more general assessments of political acceptability. Estimates of freeridership in the area of energy policy frequently rely on ex-post surveys that ask program participants whether they would have behaved differently in the absence of program support.The present paper proposes an ex-ante approach to the calculation of the free-rider share using revealed preference data on home renovations from Germany’s residential sector.We employ a discretechoice model to simulate the effect of grants on renovation choices, the output from which is used to assess the extent of free-ridership under a contemporary subsidy program. Aside from its simplicity, a key advantage of the approach is that it bestows policymakers with an estimate of free-ridership prior to program implementation.Energy efficiency, residential sector,random utility model, discrete choice simulation

    Primary Care Validation of a Single-Question Alcohol Screening Test

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    BACKGROUND Unhealthy alcohol use is prevalent but under-diagnosed in primary care settings. OBJECTIVE To validate, in primary care, a single-item screening test for unhealthy alcohol use recommended by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). DESIGN Cross-sectional study. PARTICIPANTS Adult English-speaking patients recruited from primary care waiting rooms. MEASUREMENTS Participants were asked the single screening question, "How many times in the past year have you had X or more drinks in a day?", where X is 5 for men and 4 for women, and a response of >1 is considered positive. Unhealthy alcohol use was defined as the presence of an alcohol use disorder, as determined by a standardized diagnostic interview, or risky consumption, as determined using a validated 30-day calendar method. MAIN RESULTS Of 394 eligible primary care patients, 286 (73%) completed the interview. The single-question screen was 81.8% sensitive (95% confidence interval (CI) 72.5% to 88.5%) and 79.3% specific (95% CI 73.1% to 84.4%) for the detection of unhealthy alcohol use. It was slightly more sensitive (87.9%, 95% CI 72.7% to 95.2%) but was less specific (66.8%, 95% CI 60.8% to 72.3%) for the detection of a current alcohol use disorder. Test characteristics were similar to that of a commonly used three-item screen, and were affected very little by subject demographic characteristics. CONCLUSIONS. The single screening question recommended by the NIAAA accurately identified unhealthy alcohol use in this sample of primary care patients. These findings support the use of this brief screen in primary care.National Institute on Alcohol Abuse and Alcoholism (R01-AA010870

    Flavour symmetry breaking in the kaon parton distribution amplitude

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    We compute the kaon's valence-quark (twist-two parton) distribution amplitude (PDA) by projecting its Poincare'-covariant Bethe-Salpeter wave-function onto the light-front. At a scale \zeta=2GeV, the PDA is a broad, concave and asymmetric function, whose peak is shifted 12-16% away from its position in QCD's conformal limit. These features are a clear expression of SU(3)-flavour-symmetry breaking. They show that the heavier quark in the kaon carries more of the bound-state's momentum than the lighter quark and also that emergent phenomena in QCD modulate the magnitude of flavour-symmetry breaking: it is markedly smaller than one might expect based on the difference between light-quark current masses. Our results add to a body of evidence which indicates that at any energy scale accessible with existing or foreseeable facilities, a reliable guide to the interpretation of experiment requires the use of such nonperturbatively broadened PDAs in leading-order, leading-twist formulae for hard exclusive processes instead of the asymptotic PDA associated with QCD's conformal limit. We illustrate this via the ratio of kaon and pion electromagnetic form factors: using our nonperturbative PDAs in the appropriate formulae, FK/Fπ=1.23F_K/F_\pi=1.23 at spacelike-Q2=17GeV2Q^2=17\,{\rm GeV}^2, which compares satisfactorily with the value of 0.92(5)0.92(5) inferred in e+ee^+ e^- annihilation at s=17GeV2s=17\,{\rm GeV}^2.Comment: 7 pages, 2 figures, 3 table

    Identifying Free-Riding in Energy-Conservation Programs Using Revealed Preference Data

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    Identifying the incidence of free-ridership is significant to a range of issues relevant to program evaluation, including the calculation of net program benefits and more general assessments of political acceptability. Estimates of free-ridership in the area of energy policy frequently rely on ex-post surveys that ask program participants whether they would have behaved differently in the absence of program support. The present paper proposes an ex-ante approach to the calculation of the free-rider share using revealed preference data on home renovations from Germany's residential sector. We employ a discrete-choice model to simulate the effect of grants on renovation choices, the output from which is used to assess the extent of free-ridership under a contemporary subsidy program. Aside from its simplicity, a key advantage of the approach is that it bestows policymakers with an estimate of free-ridership prior to program implementation

    BVRI Light Curves for 22 Type Ia Supernovae

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    We present 1210 Johnson/Cousins B,V,R, and I photometric observations of 22 recent type Ia supernovae (SNe Ia): SN 1993ac, SN 1993ae, SN 1994M, SN 1994S, SN 1994T, SN 1994Q, SN 1994ae, SN 1995D, SN 1995E, SN 1995al, SN 1995ac, SN 1995ak, SN 1995bd, SN 1996C, SN 1996X, SN 1996Z, SN 1996ab, SN 1996ai, SN 1996bk, SN 1996bl, SN 1996bo, and SN 1996bv. Most of the photometry was obtained at the Fred Lawrence Whipple Observatory (FLWO) of the Harvard-Smithsonian Center for Astrophysics in a cooperative observing plan aimed at improving the data base for SN Ia. The redshifts of the sample range from czcz=1200 to 37000 km s1^{-1} with a mean of czcz=7000 km s1^{-1}.Comment: Accepted to the Astronomical Journal, 41 pages, 8 figure

    Real Time Enzyme Inhibition Assays Provide Insights into Differences in Binding of Neuraminidase Inhibitors to Wild Type and Mutant Influenza Viruses

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    The influenza neuraminidase (NA) inhibitors zanamivir, oseltamivir and peramivir were all designed based on the knowledge that the transition state analogue of the cleaved sialic acid, 2-deoxy,2,3-dehydro N-acetyl neuraminic acid (DANA) was a weak inhibitor of NA. While DANA bound rapidly to the NA, modifications leading to the improved potency of these new inhibitors also conferred a time dependent or slow binding phenotype. Many mutations in the NA leading to decreased susceptibility result in loss of slow binding, hence this is a phenotypic marker of many but not all resistant NAs. We present here a simplified approach to determine whether an inhibitor is fast or slow binding by extending the endpoint fluorescent enzyme inhibition assay to a real time assay and monitoring the changes in IC50s with time. We carried out two reactions, one with a 30 min preincubation with inhibitor and the second without. The enzymatic reaction was started via addition of substrate and IC50s were calculated after each 10 min interval up to 60 min. Results showed that without preincubation IC50s for the wild type viruses started high and although they decreased continuously over the 60 min reaction time the final IC50s remained higher than for pre-incubated samples. These results indicate a slow equilibrium of association and dissociation and are consistent with slow binding of the inhibitors. In contrast, for viruses with decreased susceptibility, preincubation had minimal effect on the IC50s, consistent with fast binding. Therefore this modified assay provides additional phenotypic information about the rate of inhibitor binding in addition to the IC50, and critically demonstrates the differential effect of incubation times on the IC50 and Ki values of wild type and mutant viruses for each of the inhibitors

    From the internal market to a banking union: A proposal by the German Council of Economic Experts

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    The European sovereign debt crisis has revealed severe flaws in the design of the internal market. Both, private and public borrowers had incentives for excessive borrowing, which have been created by deficits in the regulatory structure of financial markets. Capital requirements for banks were too low and had procyclical effects (Favara and Ratnovski 2012). Supervision has been ineffective with regard to containing the build-up of risks in banks' balance sheets. Common monetary policy in the Euro Area has not been accompanied by the transfer of authority to supervise and restructure banks which has, in turn, created incentives to shift risks to the European level. Risks of banks and states have become dangerously intertwined. Proposals for a banking union aim at correcting these deficits. In principle, a banking union is a necessary complement to other elements of the internal market. In an integrated capital market, banking distress in one country can have negative externalities for the stability of financial systems in other countries. Such risks are even more pronounced if other countries are affected through a common monetary policy. The banking union currently being discussed has three elements (President of the European Council 2012): banking supervision at the European level, a European authority for bank restructuring and resolution financed by a bank resolution fund, and a European deposit insurance fund. So far, concrete proposals have been made for the establishment of a Single Supervisory Mechanism only. However, a banking union is a long-term project. It is not the key to a solution to the acute problems in Europe's banking sectors (Buch and Weigert 2012, GCEE 2012a).Die europäische Schuldenkrise hat zentrale Defizite des Binnenmarkts offengelegt. Regulatorische Defizite haben Anreize geschaffen, eine zu hohe Verschuldung einzugehen. Zwar wurde eine einheitliche Geldpolitik verfolgt, gleichzeitig aber die Kompetenzen für die Aufsicht und Restrukturierung von Banken auf nationaler Ebene belassen. So sind Anreize entstanden, Risiken auf die europäische Ebene zu verlagern. Eine Bankenunion und die Etablierung eines einheitlichen Aufsichtsmechanismus haben das Ziel, diese Defizite zu beheben. Grundsätzlich ist eine Bankenunion eine notwendige Ergänzung des Binnenmarkts. Sie ist aber vor allem ein langfristiges Projekt, das keinesfalls das aktuelle Problem des privaten und öffentlichen Schuldenüberhangs lösen kann (Buch und Weigert, 2012; SVR, 2012a)

    Spectroscopic characterization of reaction centers of the (M)Y210W mutant of the photosynthetic bacterium Rhodobacter sphaeroides

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    The tyrosine-(M)210 of the reaction center of Rhodobacter sphaeroides 2.4.1 has been changed to a tryptophan using site-directed mutagenesis. The reaction center of this mutant has been characterized by low-temperature absorption and fluorescence spectroscopy, time-resolved sub-picosecond spectroscopy, and magnetic resonance spectroscopy. The charge separation process showed bi-exponential kinetics at room temperature, with a main time constant of 36 ps and an additional fast time constant of 5.1 ps. Temperature dependent fluorescence measurements predict that the lifetime of P* becomes 4–5 times slower at cryogenic temperatures. From EPR and absorbance-detected magnetic resonance (ADMR, LD-ADMR) we conclude that the dimeric structure of P is not significantly changed upon mutation. In contrast, the interaction of the accessory bacteriochlorophyll BA with its environment appears to be altered, possibly because of a change in its position
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