Sintesi di nuovi inibitori allosterici di PDK1 a struttura 1,2-diidropiridin-3-carbossiammidica per il trattamento del tumore al pancreas

La conoscenza dei meccanismi alla base della crescita e della diffusione del cancro ha indirizzato la ricerca verso lo sviluppo di nuovi bersagli farmacologici capaci di interferire con le vie di segnalazione coinvolte in tali processi. Studi condotti negli ultimi decenni hanno individuato il pathway PI3K/PDK1 come possibile target per la sintesi di nuove molecole ad azione antitumorale. Alterazioni a tale livello sono difatti implicate nei processi di crescita incontrollata, nello sviluppo di metastasi e nell’insorgenza dei meccanismi di resistenza alla chemioterapia. Nel laboratorio presso il quale ho svolto la mia tesi di laurea, in una prima fase, è stato sintetizzato ex-novo il composto IB35, in quantità adeguate da permetterne lo studio farmacologico, sia in vitro che in vivo, nel tumore al pancreas, forma tumorale particolarmente resistente alle terapie convenzionali. In una seconda fase sono stati, invece, stati progettati e sintetizzati nuovi derivati ibridi ottenuti dalla condensazione del nucleo indolonico, caratteristico di BX 517 e capace di interagire con il sito di legame dell’ATP di PDK1, con il nucleo N-difluorobenzil 2-oxo piridinico, che rappresenta la porzione farmacoforica di MP7 legante il dominio DFG-out

White Paper: Designing the perfect New European Bauhaus neighbourhood

The concept of Smart Healthy Age-Friendly Environments (SHAFE) emphasises the comprehensive person-centred experience as essential to promoting living environments. SHAFE takes an interdisciplinary approach, conceptualising complete and multidisciplinary solutions for an inclusive society. From this approach, we promote participation, health, and well-being experiences by finding the best possible combinations of social, physical, and digital solutions in the community. This initiative emerged bottom-up in Europe from the dream and conviction that innovation can improve health equity, foster caring communities, and sustainable development. Smart, adaptable, and inclusive solutions can promote and support independence and autonomy throughout the lifespan, regardless of age, gender, disabilities, cultural differences, and personal choices, as well as promote happier and fairer living places. The New European Bauhaus initiative gathers "beautiful, sustainable, and inclusive projects and ideas" to inspire a positive transformation around us. The New European Bauhaus 2024 Festival took place between 9-13 April. "Designing the perfect New European Bauhaus neighbourhood: New European Bauhaus meets SHAFE" was a Satellite Event of the Festival, held as an online workshop, organised by the SHAFE Foundation on April 9th, 2024. At the event, a group of 50 participants with a multidisciplinary background discussed how to meet the challenges of the European Garcia family to enable them to live in a perfect neighbourhood. The White Paper presents the findings of the participants with the New European Bauhaus inspiring projects and ideas to house the European Garcia family in their neighbourhood. The White Paper recommends developers, designers, planners, and policymakers to include person-centred design of social and physical environments and technologies. Although awareness of person-centred design is growing, many initiatives still hamper the inclusion of citizens or end-users throughout the development of products and services

White Paper: Designing the perfect New European Bauhaus neighbourhood

The concept of Smart Healthy Age-Friendly Environments (SHAFE) emphasises the comprehensive person-centred experience as essential to promoting living environments. SHAFE takes an interdisciplinary approach, conceptualising complete and multidisciplinary solutions for an inclusive society. From this approach, we promote participation, health, and well-being experiences by finding the best possible combinations of social, physical, and digital solutions in the community. This initiative emerged bottom-up in Europe from the dream and conviction that innovation can improve health equity, foster caring communities, and sustainable development. Smart, adaptable, and inclusive solutions can promote and support independence and autonomy throughout the lifespan, regardless of age, gender, disabilities, cultural differences, and personal choices, as well as promote happier and fairer living places. The New European Bauhaus initiative gathers “beautiful, sustainable, and inclusive projects and ideas” to inspire a positive transformation around us. The New European Bauhaus 2024 Festival took place between 9-13 April. “Designing the perfect New European Bauhaus neighbourhood: New European Bauhaus meets SHAFE” was a Satellite Event of the Festival, held as an online workshop, organised by the SHAFE Foundation on April 9th, 2024

Environmental design for SHAFE approach

The World report on ageing and health highlighted the need to ensure age-friendly environments to foster active and healthy ageing because, as the World Health Organization has estimated, the number of people over 60 is set to double by 2050. Recently, SHAFE (Smart, Healthy, Age-Friendly Environments) has been proposed as a design approach to face the challenge of ageing. SHAFE model is focused on two goals: the promotion of smart and inclusive solutions to improve the independent life throughout the life course, regardless of age, gender, disabilities, cultural differences and personal choices; the optimization of social and physical environments, supported by digital tools and services. Nevertheless, studies on how to apply integrated principles of SHAFE to architectural design are still lacking, even if the interdisciplinary network NET4Age-Friendly is the most recent application of SHAFE model and aims to implement its practice and deployment. Based on a literature review, the paper discusses the contribution of environmental design for improving SHAFE approach on architecture, to build living spaces really responding to the changing needs of people from the ageing in place to the long-life approach