Synthesis of isoniazid-aldehyde codrugs and their activities against multidrug-resistant mycobacterium tuberculosis

In response to the need for drugs to combat multidrug-resistant tuberculosis (MDR-TB), four isoniazid-aldehyde derivatives have been synthesized, characterized and tested as antimycobacterial agents. The prepated imines were characterized by spectroscopy, FT-IR spectroscopy, HPLC, and 1H and 13C NMR spectroscopy. the expected structure of N\u27-[(E)-(4-medthoxyphenyl)methylene]isonicotinohydrazide and N\u27-[(1E,2Z)-2-bromo-3-phenyl-2propen-1ylidene]isonicotinohydrazide agress with their 1H and13C NMR spectra. Minimum inhibitory concentrations (MIC) of the four products against MDR-TB strain were determined using resazurin mictotiter assay (REMA). The codrugs were found to be less active compared to reference drugs isoniazid, ofloxacin and levofloxacin. For the first time, p-anisaldehyde and and a-bromocinnamaldehyde were reported to have an activity against MDR-TB. Furthermore, a-bromocinnamaldehyde was found to be more active than isoniazid

Effectiveness of Thai Chi in improving balance among patients with chronic stroke

In this pre-experimental study, 27 respondents were selected based on a set inclusion criteria. Out of the 27 participants, 18 agreed to join the study and two (2) respondents dropped out. Baseline and post-test measurements were assessed using the Berg Balance Scale. The intervention used was eight (8) sessions of Tai Chi guided by a video prescribed by a Tai Chi instructor to improve balance. Dependent t-test showed that the balance of the patients with chronic stroke significantly improved after the Tai Chi program except for the three (3) respondents who skipped treatment