Leptonic Generation Mixing, Noncommutative Geometry and Solar Neutrino Fluxes

Triangular mass matrices for neutrinos and their charged partners contain full information on neutrino mixing in a most concise form. Although the scheme is general and model independent, triangular matrices are typical for reducible but indecomposable representations of graded Lie algebras which, in turn, are characteristic for the standard model in noncommutative geometry. The mixing matrix responsible for neutrino oscillations is worked out analytically for two and three lepton families. The example of two families fixes the mixing angle to just about what is required by the Mikheyev-Smirnov-Wolfenstein resonance oscillation of solar neutrinos. In the case of three families we classify all physically plausible choices for the neutrino mass matrix and derive interesting bounds on some of the moduli of the mixing matrix.Comment: LaTeX, 12 page

Quantum Gravity coupled to Matter via Noncommutative Geometry

We show that the principal part of the Dirac Hamiltonian in 3+1 dimensions emerges in a semi-classical approximation from a construction which encodes the kinematics of quantum gravity. The construction is a spectral triple over a configuration space of connections. It involves an algebra of holonomy loops represented as bounded operators on a separable Hilbert space and a Dirac type operator. Semi-classical states, which involve an averaging over points at which the product between loops is defined, are constructed and it is shown that the Dirac Hamiltonian emerges as the expectation value of the Dirac type operator on these states in a semi-classical approximation.Comment: 15 pages, 1 figur

Quasi-Dirac Operators and Quasi-Fermions

We investigate examples of quasi-spectral triples over two-dimensional commutative sphere, which are obtained by modifying the order-one condition. We find equivariant quasi-Dirac operators and prove that they are in a topologically distinct sector than the standard Dirac operator.Comment: 11 page

Neurohumoral stimulation in type-2-diabetes as an emerging disease concept

Neurohumoral stimulation comprising both autonomic-nervous-system dysfunction and activation of hormonal systems including the renin-angiotensin-aldosterone system (RAAS) was found to be associated with Type-2-diabetes (T2D). Therapeutic strategies such as RAAS interference proved to be beneficial in both T2D treatment and prevention. In addition to an activated RAAS, hyperleptinemia in obesity, hyperinsulinemia in conditions of peripheral insulin resistance and overall oxidative stress in T2D represent known activators of the sympathetic component of the autonomic nervous system. Here, we hypothesize that sympathetic activation may cause peripheral insulin resistance defined as partial blocking of insulin effects on glucose uptake. Resulting hyperinsulinemia or hyperglycemia-related oxidative stress may further aggravate sympatho-excitation. This notion leads to a secondary hypothesis: sympathetic activation worsens from obesity towards insulin resistance, and further towards T2D. In this review, existing evidence relating to neurohumoral stimulation in T2D and consequences thereof, such as oxidative stress and inflammation, are discussed. The aim of this review is to provide a rationale for therapies, which are able to intercept neuroendocrine pathways in T2D and precursor states such as obesity