1 research outputs found
The Investigation of Effects of Blood Exchange Transfusion on Selenium in Newborn Infants by Instrumental Neutron Activation Analysis Method
Objective: The evidence for the effects of blood exchange transfusion
on selenium (Se) in newborn infants is unknown. This study was
conducted to determine the possible effects of blood exchange
transfusion on Se by comparing the Se blood concentrations before and
after exchange transfusion in jaundiced neonates. Methods: A total of
30 jaundiced term neonates who underwent blood exchange transfusion
(EXT) for first time because of idiopathic unconjugated
hyperbilirubinemia, were recruited. The Se level of 30 blood bank
donors' samples used for EXT were measured and 30 pairs of
uncontaminated umbilical cord blood samples were investigated for Se
before and after exchange transfusion. The samples were analyzed by
instrumental neutron activation analysis method. Serum bilirubin
concentrations were measured by venous blood samples before EXT.
Findings: The average of Se concentration before EXT was higher than
that after EXT (629.78±283.82 SD ppb versus 454.83±213.75 SD
ppb) (P<0.05). There was significant correlation between the blood
concentration of Se before and after EXT and also between the blood
level of Se before EXT and total serum bilirubin level (P<0.05).
There was no significant correlation between the blood concentration of
Se before EXT and babies' gender and weight (P>0.05). The average Se
level in samples obtained from transfused blood products was
507.90±223.56 SD ppb. ±Conclusion: Blood exchange transfusion
caused a 28% decrease of the blood Se level because the blood donors
had lower blood Se levels than the newborns. Furthermore, there was a
significant correlation between the blood level of Se before EXT and
the total serum bilirubin level