18 research outputs found
Contribution à l'étude du pouvoir antioxydant des antiinflammatoires non stéroidiens
Doctorat en sciences pharmaceutiquesinfo:eu-repo/semantics/nonPublishe
Interaction of nonsteroidal antiinflammatory drugs with horseradish peroxidase in an assay for H2O2 scavenging
info:eu-repo/semantics/nonPublishe
Effet antiradicalaire des antiinflammatoires non stéroïdiens
info:eu-repo/semantics/nonPublishe
Application de la méthode au déoxyribose à l'évaluation du pouvoir antiradicalaire (radical hydroxyle) des antiinflammatoires: étude des paramètres expérimentaux et problèmes méthodologiques
info:eu-repo/semantics/publishe
Application de techniques de peroxydation d'érythrocytes intacts à l'évaluation de l'activité antioxydante de molécules médicamenteuses
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs investigated with a human recombinant enzyme
Non-steroidal anti-inflammatory drugs (NSAIDs) were investigated for their ability to affect the chlorinating activity of human myeloperoxidase and to scavenge HOCl, the main myeloperoxidase system product. Fourteen drugs representative of various NSAIDs families were tested with the chlorination of taurine used as a detection system. All were unable to inhibit taurine chlorination in a system without myeloperoxidase. In contrast, most of them induced a dose-dependent inhibition of the taurine chlorination mediated by a myeloperoxidase/H2O2/Cl- system. This took place at variable drug concentrations and IC50 were calculated. The inhibitory effect was therefore due to a direct interaction with the enzyme rather than to HOCl scavenging. A spectroscopic method used to measure the myeloperoxidase compound II lifetime in presence of the different drugs showed that all the drugs, which inhibited chlorination activity were able to induce accumulation of compound II. The extent of chlorinating activity inhibition (IC50) was inversely related to the duration of the block of enzyme in compound II form. This further demonstrates that myeloperoxidase is an interesting target for anti-inflammatory therapy. The recombinant myeloperoxidase used for the first time in this kind of study was as convenient for pharmacological purposes as the purified one. © 2001 Elsevier Science B.V.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Deviation from linearity of competition plots in the deoxyribose assay for determination of rate constants for reaction of some non steroidal antiinflammatory drugs with hydroxyl radicals
info:eu-repo/semantics/nonPublishe
Linear and non linear competition plots in the deoxyribose assay for determination of rate constants for reaction of non steroidal antiinflammatory drugs with hydroxyl radicals
info:eu-repo/semantics/publishe
Chimie pharmaceutique et analyse des médicaments organiques
info:eu-repo/semantics/publishe
Chimie pharmaceutique et analyse des médicaments organiques :travaux pratiques
1re édition 1994-1995/1A l'usage des étudiants des années du grade en Sciences Pharmaceutiquesinfo:eu-repo/semantics/published