Targeting in situ and imaging multiple inflammatory biomarkers with quantum dots in DSS model of colitis

Poster presented at Biomedical Technology Showcase 2006, Philadelphia, PA. Retrieved 18 Aug 2006 from http://www.biomed.drexel.edu/new04/Content/Biomed_Tech_Showcase/Poster_Presentations/Papazoglou_6.pdf.Inflammatory Bowel Disease affects nearly 1.5 million people. Currently, there are no efficient and reliable methods to quantify the degree of inflammation in these patients. The objective here was to image and quantify in an experimental model of colitis, MPO, IL1_ and TNF_ (proinflammatory cytokines) using Quantum Dots (QDs) conjugated with specific antibodies. The resulting fluorescence intensity was then used as a measure of concentration of MPO and in turn inflammation. The fluorescent images obtained from animals showed sequential increase in fluorescence intensity of MPO correlating (R = 0.96) with clinical disease. Fluorescent images also showed co-localization of all the three markers in both acute as well as chronic inflammation. These observations suggest that QD bioconjugates can be used nanotools to image biomarkers of inflammation

Ofeleein i mi Vlaptin-Volume II: Immunity Following Infection or mRNA Vaccination, Drug Therapies and Non-Pharmacological Management at Post-Two Years SARS-CoV-2 Pandemic.

The persistence of the coronavirus disease 2019 (COVID-19) pandemic has triggered research into limiting transmission, morbidity and mortality, thus warranting a comprehensive approach to guide balanced healthcare policies with respect to people's physical and mental health. The mainstay priority during COVID-19 is to achieve widespread immunity, which could be established through natural contact or vaccination. Deep knowledge of the immune response combined with recent specific data indicates the potential inferiority of induced immunity against infection. Moreover, the prevention of transmission has been founded on general non-pharmacological measures of protection, albeit debate exists considering their efficacy and, among other issues, their socio-psychological burden. The second line of defense is engaged after infection and is supported by a plethora of studied agents, such as antibiotics, steroids and non-steroid anti-inflammatory drugs, antiviral medications and other biological agents that have been proposed, though variability in terms of benefits and adverse events has not allowed distinct solutions, albeit certain treatments might have a role in prevention and/or treatment of the disease. This narrative review summarizes the existing literature on the advantages and weaknesses of current COVID-19 management measures, thus underlining the necessity of acting based on the classical principle of "ofeleein i mi vlaptin", that is, to help or not to harm

Bionanotechnology

This book aims to provide vital information about the growing field of bionanotechnology for undergraduate and graduate students, as well as working professionals in various fields. The fundamentals of nanotechnology are covered along with several specific bionanotechnology applications, including nanobioimaging and drug delivery which is a growing 100 billions industry. The uniqueness of the field has been brought out with unparalleled lucidity; a balance between important insight into the synthetic methods of preparing stable nano-structures and medical applications driven focus educates an

Optical diagnosis and treatment optimization in chronic diabetic wound

Progress report presented at Biomedical Technology Showcase 2006, Philadelphia, PA. Retrieved 18 Aug 2006 from http://www.biomed.drexel.edu/new04/Content/Biomed_Tech_Showcase/ProgrReport_Presentations/Papazoglou_NIR_Wounds.pdf

What the user wants: Drexel engineering perspectives

Presented at "What’s Next? - Embracing Change" PALINET Workshop, Philadelphia and Pittsburgh, PA, April 10th & 11th, 2007. Retrieved June 19, 2007 from http://www.biomed.drexel.edu/new04/Content/academics/student_alumni_center/User_Needs.pdf

An introduction to Bionanotechnology: an interdisciplinary educational program

Poster presented at Biomedical Technology Showcase 2006, Philadelphia, PA. Retrieved 18 Aug 2006 from http://www.biomed.drexel.edu/new04/Content/Biomed_Tech_Showcase/Poster_Presentations/Barbee_3.pdf.Nanotechnology is evolving into a powerful tool and education at the college level is necessary to transform the opportunities into useful biomedical applications. Also appropriate policy decisions regarding safety and use of Bionanotechnology can occur only when thorough research results are disseminated to the public. Drexel Biomed is leading in creating novel lecture, book and lab materials for Bionanotechnology. Thus evolved the program Bionanotechnology, providing scientific knowledge to students via courses and reaching the research scholars through an introductory book

Optical properties of animal tissue as diabetes progresses

Poster presented at Biomedical Technology Showcase 2006, Philadelphia, PA. Retrieved 18 Aug 2006 from http://www.biomed.drexel.edu/new04/Content/Biomed_Tech_Showcase/Poster_Presentations/Papazoglou_7.pdf.Diffuse photon density wave methodology in the near infrared range was used to calculate absorption and scattering in wounds of healthy and diabetic rats. Differences observed as diabetes progresses can be correlated to the delayed healing observed in diabetics