Do text-free diffusion models learn discriminative visual representations?

While many unsupervised learning models focus on one family of tasks, either generative or discriminative, we explore the possibility of a unified representation learner: a model which addresses both families of tasks simultaneously. We identify diffusion models, a state-of-the-art method for generative tasks, as a prime candidate. Such models involve training a U-Net to iteratively predict and remove noise, and the resulting model can synthesize high-fidelity, diverse, novel images. We find that the intermediate feature maps of the U-Net are diverse, discriminative feature representations. We propose a novel attention mechanism for pooling feature maps and further leverage this mechanism as DifFormer, a transformer feature fusion of features from different diffusion U-Net blocks and noise steps. We also develop DifFeed, a novel feedback mechanism tailored to diffusion. We find that diffusion models are better than GANs, and, with our fusion and feedback mechanisms, can compete with state-of-the-art unsupervised image representation learning methods for discriminative tasks - image classification with full and semi-supervision, transfer for fine-grained classification, object detection and segmentation, and semantic segmentation. Our project website (https://mgwillia.github.io/diffssl/) and code (https://github.com/soumik-kanad/diffssl) are available publicly.Comment: Website: see https://mgwillia.github.io/diffssl/ . Code: see https://github.com/soumik-kanad/diffssl . The first two authors contributed equally. 15 pages, 9 figures, 15 tables. Submission under review. (this article supersedes arXiv:2307.08702

Phase I study of MLN8237—investigational Aurora A kinase inhibitor—in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia

Purpose Amplification or over-expression of the mitotic Aurora A kinase (AAK) has been reported in several heme-lymphatic malignancies. MLN8237 (alisertib) is a novel inhibitor of AAK that is being developed for the treatment of advanced malignancies. The objectives of this phase I study were to establish the safety, tolerability, and pharmacokinetic profiles of escalating doses of MLN8237 in patients with relapsed or refractory heme-lymphatic malignancies. Methods Sequential cohorts of patients received MLN8237 orally as either a powder-in-capsule (PIC) or enteric-coated tablet (ECT) formulation. Patients received MLN8237 PIC 25–90 mg for 14 or 21 consecutive days plus 14 or 7 days’ rest, respectively, or MLN8237 ECT, at a starting dose of 40 mg/day once-daily (QD) for 14 days plus 14 days’ rest, all in 28-day cycles. Subsequent cohorts received MLN8237 ECT 30–50 mg twice-daily (BID) for 7 days plus 14 days’ rest in 21-day cycles. Results Fifty-eight patients were enrolled (PIC n = 28, ECT n = 30). The most frequent grade ≥3 drug-related toxicities were neutropenia (45 %), thrombocytopenia (28 %), anemia (19 %), and leukopenia (19 %). The maximum tolerated dose on the ECT 7-day schedule was 50 mg BID. The terminal half-life of MLN8237 was approximately 19 h. Six (13 %) patients achieved partial responses and 13 (28 %) stable disease. Conclusion The recommended phase II dose of MLN8237 ECT is 50 mg BID for 7 days in 21-day cycles, which is currently being evaluated as a single agent in phase II/III trials in patients with peripheral T-cell lymphoma. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10637-013-0050-9) contains supplementary material, which is available to authorized users

Some investigations on the forming behaviour of an indigenous extra-deep drawing low carbon steel: I. Experimental results

This article does not have an abstract

On the correlation between the stress state of deformation and fracture behaviour in an extra-deep drawing low carbon steel

With the aid of a scanning electron microscope, the fracture behaviour of an indigenously produced Al killed, extra-deep drawing, low C steel was studied for varying degrees of bi-axial (tensile) deformation. Using the features present on the fracture surface as indicators, for the first time a meaningful correlation could be established between the stress state and ductility. These results provided confirmatory evidence for the conclusions reached from some formability studies (reported elsewhere), apart from adding useful complementary information. The inferior ductility of one of the six heats used in the study--in spite of its excellent texture, a favourable grain size and a high average plastic strain ratio--could be traced to the detrimental alignment along the rolling direction of sulphide stringers and other inclusions. Graphs, photomicrographs

The formability and fracture behaviour of an extra-deep drawing steel and two aluminium-based alloys

This article does not have an abstract

On the correlation between annealing textures and formability in an extra-deep drawing low-carbon steel

This article does not have an abstract

Targeting CLL-1 for acute myeloid leukemia therapy

Abstract Despite major scientific discoveries and novel therapies over the past four decades, the treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient population remain dismal. In the past few years, an increasing number of targets such as CD33, CD123, CLL-1, CD47, CD70, and TIM3, have been developed for immunotherapy of AML. Among them, CLL-1 has attracted the researchers’ attention due to its high expression in AML while being absent in normal hematopoietic stem cell. Accumulating evidence have demonstrated CLL-1 is an ideal target for AML. In this paper, we will review the expression of CLL-1 on normal cells and AML, the value of CLL-1 in diagnosis and follow-up, and targeting CLL-1 therapy-based antibody and chimeric antigen receptor T cell therapy as well as providing an overview of CLL-1 as a target for AML

Room Temperature formability and fracture behavior of a high strength Al-Zn-Mg alloy

The formability and fracture behavior of a high strength, aluminum alloy made to (French) specification AFNOR 7020 is reported. The formability study included the evaluation of the room temperature forming limit diagram (FLD) of the material in the T4 temper and an analysis of the strain distribution profiles obtained in punch stretching that involved different stress states. The fracture surfaces were examined by scanning electron microscopy and a correlation between the forming and fracture behavior could be obtained