Mid-Infrared Imaging of the Protostellar Binary L1448N--IRS3(A,B)

Mid-infrared (10-25 \micron) imaging of the protostellar binary system L1448N-IRS3(A,B) is presented. Only one source, IRS3(A), was detected at mid-infrared wavelengths -- all of the mid-infrared emission from IRS3(A,B) emanates from IRS3(A). The mid-infrared luminosity of IRS3(A) is L_{midir} = 1.3(\frac{d}{300\rm{pc}})^2 L_\sun, which yields a central source mass, depending on the mass infall rate, of M_* = 0.2 M_\sun \frac{10^{-6}M_\sun yr^{-1}}{\dot M}. The envelope mass surrounding IRS3(A) is \sim 0.15 M_\sun, suggesting that the central source and the envelope are of comparable mass. The locations of IRS3(A) and IRS3(B) on an $M_{env} - L_{bol}$ diagram indicate that IRS3(A) and IRS3(B) appear to be class I and class 0 protostars, respectively.Comment: Accepted for publication in The Astrophysical Journa

Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia : Results From a UK National Register

The British Society for Rheumatology (BSR) Biologics Register in Ankylosing Spondylitis is funded by the BSR and they have receive funds for this from Pfizer, AbbVie and UCB. These companies receive advance copies of manuscripts and can provide comments but have no input into determining the topics for analysis, publication and no input into the work involved in this analysis. This analysis is part-funded by Arthritis Research UK (Grant No: 21378)Peer reviewedPublisher PD

Toward a spatial understanding of openness: Richard Sennett’s “five open forms” and/in music

This article offers a new strategy for cognizing musical indeterminacy based on Richard Sennett’s “five open forms for the city,” an intrinsically spatial way of thinking about what is “open” and how it is open. Sennett’s five forms (“synchronicity,” “punctuatedness,” “porosity,” “incompleteness,” and “multiplicity”) are explored individually as they impact our understanding of openness and/in music, illuminated by examples from contemporary experimental music

Scoring the journey: listening to Claudia Molitor's Sonorama

Sonorama is a 2015 sonic artwork by Claudia Molitor, consisting of a number of audio files designed for listening on a train journey between London St Pancras and Margate, and a graphic score based on the composer's own ‘reading’ of this journey. This article analyses the relationship between the sonic and the spatial in the work, exploring how Molitor's site-specific composition interacts with its environment on multiple scales. By drawing on the strategy of ‘situated listening’ developed by Gascia Ouzounian, as well as urbanist language introduced by Richard Sennett, this article seeks to elucidate the relationship between a number of ‘nested’ spaces, present across varying realisations, and the political agenda that energises the work. Written in the midst of summer 2015's European refugee crisis, the work brings into sharp focus themes of British exceptionalism, immigration and inclusion

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation

Watercress is a rich source of phytochemicals with anticancer potential, including phenethyl isothiocyanate (PEITC). We examined the potential for watercress extracts and PEITC to increase the DNA damage caused by ionising radiation (IR) in breast cancer cells and to be protective against radiation-induced collateral damage in healthy breast cells. The metabolic events that mediate such responses were explored using metabolic profiling. H nuclear magnetic resonance spectroscopy-based metabolic profiling was coupled with DNA damage-related assays (cell cycle, Comet assay, viability assays) to profile the comparative effects of watercress and PEITC in MCF-7 breast cancer cells and MCF-10A non-tumorigenic breast cells with and without exposure to IR. Both the watercress extract and PEITC-modulated biosynthetic pathways of lipid and protein synthesis and resulted in changes in cellular bioenergetics. Disruptions to the redox balance occurred with both treatments in the two cell lines, characterised by shifts in the abundance of glutathione. PEITC enhanced the sensitivity of the breast cancer cells to IR increasing the effectiveness of the cancer-killing process. In contrast, watercress-protected non-tumorigenic breast cells from radiation-induced damage. These effects were driven by changes in the cellular content of the antioxidant glutathione following exposure to PEITC and other phytochemicals in watercress. These findings support the potential prophylactic impact of watercress during radiotherapy. Extracted compounds from watercress and PEITC differentially modulate cellular metabolism collectively enhancing the therapeutic outcomes of radiotherapy

Séance and technology: intermundane communication as a methodology for contemporary music

This article examines compositions that stage communion with spirits via technological means. Through analysis of four works, it proposes ‘séancing’ as both a framework for interpreting performances of technologically focused contemporary music, and as a credible methodology for new music composition. In Francesca Fargion’s Louise, gently falling (2023), Vochlea’s Dubler 2 conjures a spectral vocalist that energises both rehearsal and performance. In Laurence Osborn’s Counterfeits (Siminică) (2023), Augmented Instruments Lab’s TouchKeys help stage a theatrical séance that blurs intermundane boundaries. Nwando Ebizie uses Google’s LaMDA (Language Model for Dialogue Applications) to explore questions of sapience, pedagogy, and possession in I Will Fix Myself (Just Circles) (2022). Zubin Kanga’s Metamemory (2023) makes use of PriSM SampleRNN to blur distinctions between real recorded performances and techno-hallucinogenic fictions

New Frontiers for Terrestrial-sized to Neptune-sized Exoplanets In the Era of Extremely Large Telescopes

Surveys reveal that terrestrial- to Neptune-sized planets (1 $< R <$ 4 R$_{\rm{Earth}}$) are the most common type of planets in our galaxy. Detecting and characterizing such small planets around nearby stars holds the key to understanding the diversity of exoplanets and will ultimately address the ubiquitousness of life in the universe. The following fundamental questions will drive research in the next decade and beyond: (1) how common are terrestrial to Neptune-sized planets within a few AU of their host star, as a function of stellar mass? (2) How does planet composition depend on planet mass, orbital radius, and host star properties? (3) What are the energy budgets, atmospheric dynamics, and climates of the nearest worlds? Addressing these questions requires: a) diffraction-limited spatial resolution; b) stability and achievable contrast delivered by adaptive optics; and c) the light-gathering power of extremely large telescopes (ELTs), as well as multi-wavelength observations and all-sky coverage enabled by a comprehensive US ELT Program. Here we provide an overview of the challenge, and promise of success, in detecting and comprehensively characterizing small worlds around the very nearest stars to the Sun with ELTs. This white paper extends and complements the material presented in the findings and recommendations published in the National Academy reports on Exoplanet Science Strategy and Astrobiology Strategy for the Search for Life in the Universe.Comment: Astro2020 Science White Pape

REFLECTIONS ON CYBORG COLLABORATIONS:CROSS-DISCIPLINARY COLLABORATIVE PRACTICE IN TECHNOLOGICALLY-FOCUSED CONTEMPORARY MUSIC

Creating new works combining live musicians with new technologies provides both opportunities and challenges. The Cyborg Soloists research project has commissioned and managed the creation of 46 new works of this type, assembling teams of composers, performers, researchers and technology partners from industry. The majority of these collaborations have been smooth-running and fruitful, but a few have demonstrated complications. This article critically evaluates collaborative methods and methodologies used in the project so far, presenting five case studies involving different types of collaborative work, and exploring the range of professional relationships, the need for different types of expertise within the team and the way technology can act as both a creative catalyst and a source of creative resistance. The conclusions are intended as a toolkit – pragmatic guidelines to inform future practice – and are aimed at artists, technological collaborators, and commissioners and organisations who facilitate these types of creative collaborations