Oligohydramnios sequence and a variant of Dandy-Walker syndrome

Dandy-Walker syndrome is frequently associated with disorders of other areas of the central nervous system, including absence of the area made up of nerve fibers connecting the two cerebral hemispheres (corpus callosum) and malformations of the heart, face, limbs, fingers and toes. In the diagnostic workup, ultrasound is reliable and accurate for making the diagnosis. For diagnostic purposes and confirmation of diagnosis, foetal MRI in utero also has been advocated. Further confirmation may be done with autopsy of neonate after birth. Most of the pregnancies are terminated after antenatal diagnosis on anomaly scan. However if born alive the survival depends on associated anomalies in other systems

Pyrexia in pregnancy: an atypical presentation

Every year approximately 50 million women living in malaria endemic areas become pregnant and are at high risk of adverse health impact of malaria. Pregnancy appears to interfere with immune process in malaria and the disease itself alters immune reactivity. Malaria is a parasite infestation with protozoan Plasmodium; transmitted through bite of female Anopheline mosquito. We present a case of 25 week multigravida with vivax malaria complaining of breathlessness. On further investigations, patient was found to have bilateral pleural effusion.

Growth and Hemato-Immunological Response to Dietary i-Carrageenan in Labeo rohita (Hamilton, 1822) Juveniles

The study was performed over a period of 60 days to evaluate the effect of dietary carrageenan on growth, hematology, biochemistry, and innate immunity in rohu Labeo rohita. A basal diet supplemented with iota (i)Carrageenan at 5, 10 and 20g/kg was fed to three different groups of fish for 60 days. The fish were examined 15, 30, 45, and 60 days after commencement of the study. Parameters for growth (absolute growth, specific growth rate, and percentage weight gain), hematology (total erythrocyte count, total leucocyte count, thrombocyte count and hemoglobin value), biochemistry (total serum protein, albumin, globulin and albuminglobulin ratio), and innate immunity (nitroblue tetrazolium NBT, and myeloperoxidase MPO, activity) were monitored to assess the effect of the iCarrageenan based diet in L. rohita. All the parameters examined (growth, hematology, biochemistry, and innate immunity) increased significantly (P<0.05) in carrageenan-fed groups compared to the control group. However, the highest values for those parameters were found on the 60th day in the group which was fed a 10 g/kg i-Carrageenan diet. The study suggests that a 10 g/kg diet of i-carrageenan enhances immunity and the overall health status in L. rohita

Physiochemical Characteristics Analysis of Garrah River Water at Shahjahanpur, Ganga River Basin, Uttar Pradesh, India

This study focuses on the physiochemical analysis of the Garrah River in Shahjahanpur, within the Ganga River Basin, Uttar Pradesh, India. The research evaluates the impact of various pollutants, including industrial and municipal sewage, on the river's water quality. Water samples were collected from three locations along the river, representing different pollution levels. The analysis included parameters such as pH, dissolved oxygen (DO), total suspended solids (TSS), color, odor, electrical conductivity, temperature, chemical oxygen demand (COD), salinity, and the concentrations of various elements. The findings showed variations in water quality parameters, with DO, TSS, COD, and heavy metals indicating significant pollution, particularly downstream. Color and odor also suggested pollution from nearby industries. The study revealed that some parameters exceeded WHO standards for drinking water, raising concerns about health risks from exposure to contaminants like chromium. Urgent actions are required to treat municipal sewage and industrial effluents before discharging into the Garrah River. This research highlights the need for ongoing monitoring and sustainable management of water resources in the Ganga River Basin to protect the ecosystem and local communities. It underscores the importance of improving water quality in the region

Optimizing Village-Level Targeting of Active Case Detection to Support Visceral Leishmaniasis Elimination in India.

Background: India has made major progress in improving control of visceral leishmaniasis (VL) in recent years, in part through shortening the time infectious patients remain untreated. Active case detection decreases the time from VL onset to diagnosis and treatment, but requires substantial human resources. Targeting approaches are therefore essential to feasibility. Methods: We analyzed data from the Kala-azar Management Information System (KAMIS), using village-level VL cases over specific time intervals to predict risk in subsequent years. We also graphed the time between cases in villages and examined how these patterns track with village-level risk of additional cases across the range of cumulative village case-loads. Finally, we assessed the trade-off between ACD effort and yield. Results: In 2013, only 9.3% of all villages reported VL cases; this proportion shrank to 3.9% in 2019. Newly affected villages as a percentage of all affected villages decreased from 54.3% in 2014 to 23.5% in 2019, as more surveillance data accumulated and overall VL incidence declined. The risk of additional cases in a village increased with increasing cumulative incidence, reaching approximately 90% in villages with 12 cases and 100% in villages with 45 cases, but the vast majority of villages had small cumulative case numbers. The time-to-next-case decreased with increasing case-load. Using a 3-year window (2016-2018), a threshold of seven VL cases at the village level selects 329 villages and yields 23% of cases reported in 2019, while a threshold of three cases selects 1,241 villages and yields 46% of cases reported in 2019. Using a 6-year window increases both effort and yield. Conclusion: Decisions on targeting must consider the trade-off between number of villages targeted and yield and will depend upon the operational efficiencies of existing programs and the feasibility of specific ACD approaches. The maintenance of a sensitive, comprehensive VL surveillance system will be crucial to preventing future VL resurgence

Development and Evaluation of Active Case Detection Methods to Support Visceral Leishmaniasis Elimination in India.

As India moves toward the elimination of visceral leishmaniasis (VL) as a public health problem, comprehensive timely case detection has become increasingly important, in order to reduce the period of infectivity and control outbreaks. During the 2000s, localized research studies suggested that a large percentage of VL cases were never reported in government data. However, assessments conducted from 2013 to 2015 indicated that 85% or more of confirmed cases were eventually captured and reported in surveillance data, albeit with significant delays before diagnosis. Based on methods developed during these assessments, the CARE India team evolved new strategies for active case detection (ACD), applicable at large scale while being sufficiently effective in reducing time to diagnosis. Active case searches are triggered by the report of a confirmed VL case, and comprise two major search mechanisms: 1) case identification based on the index case's knowledge of other known VL cases and searches in nearby houses (snowballing); and 2) sustained contact over time with a range of private providers, both formal and informal. Simultaneously, house-to-house searches were conducted in 142 villages of 47 blocks during this period. We analyzed data from 5030 VL patients reported in Bihar from January 2018 through July 2019. Of these 3033 were detected passively and 1997 via ACD (15 (0.8%) via house-to-house and 1982 (99.2%) by light touch ACD methods). We constructed multinomial logistic regression models comparing time intervals to diagnosis (30-59, 60-89 and ≥90 days with =90 days compared to the referent of <30 days for ACD vs PCD were 0.88, 0.56 and 0.42 respectively. These ACD strategies not only reduce time to diagnosis, and thus risk of transmission, but also ensure that there is a double check on the proportion of cases actually getting captured. Such a process can supplement passive case detection efforts that must go on, possibly perpetually, even after elimination as a public health problem is achieved

STUDIES ON LOSSES IN WHEAT IN RELATION TO STORAGE STRUCTURE IN THE VILLAGES OF BARH UNDER PATNA DISTRICT OF BIHAR STATE

Sixty samples from five different storage structures were collected from eight villages of Barh subdivision under Patna district of Bihar state, at an interval of 1.6 and 10 months of storage after harvest. Among various storage structures traditional method of storing wheat bags in wheat straw was found comparable to modern methods of storing wheat in metal bins and in jute bags with polythene lining. Maximum damage was observed in wheat stored injute bags

Evaluation of aircraft emission at Tribhuvan international airport and its contribution to air quality in Kathmandu, Nepal

The recent rise in the number of aircraft flights and the subsequent increase in emissions has raised concerns worldwide, and this increasing trend is expected to continue. This research provides an overall estimation of the landing and take-off cycle (LTO) emissions from Tribhuvan International Airport (TIA) as well as the associated contribution of these emissions to ambient air quality in Kathmandu valley. The aircraft emissions of nitrogen oxides (NOx), carbon monoxide (CO), hydrocarbon (HC), sulfur dioxide (SO2), volatile organic compounds (VOCs), particulate matter (PM10, and PM2.5), and black carbon (BC) during the LTO are estimated for recent 20 years by using the emission factor method. The corresponding contribution to ambient air quality was simulated using AERMOD and Weather Research and Forecasting (WRF) models. The research reveals that total LTO emissions by aircraft at TIA range from 898 to 2123 tonnes per year (2000–2019). The average LTO emissions of NOx, CO, HC, VOC, SO2, PM10, PM2.5, and BC were around 14512, 8142, 2387, 1737, 1247, 481, 472, and 231 tonnes respectively during the period of 20 years. The highest aircraft emission was shown in taxi/idle mode for the LTO cycle, with major constituents being HC and CO. The LTO emissions and their effect on air quality have continually increased. The highest contribution of the LTO emissions on air quality was found in the pre-monsoon season. The dominant pollutants in TIA were nitrogen oxides and its average 24-h concentration was 158.1 μg/m3, which exceeded the National Ambient Air Quality Standard (NAAQS) limit value. Hence, LTO emission significantly contributed to ambient air quality in Kathmandu city

Isolation, Identification, and Pathogenicity of a Virulent Aeromonas jandaei Associated with Mortality of Farmed Pangasianodon hypophthalmus, in India

The present study was conducted to investigate the bacterial pathogens involved in the mortality of cultured Pangasianodon hypophthalmus. Diseased fish samples were collected from Maharashtra, India for the isolation of pathogenic bacteria. The pathogenic bacterial isolates were identified using 16S rRNA gene sequencing analysis which revealed that they were 99% identical with Aeromonas jandaei. The bacterial isolates were further characterized using biochemical methods. The lowest bacterial dose which caused 50% cumulative mortality (LD50) in Pangasianodon hypophthalmus was 8.84 X 105 CFU per fish. This was achieved by injecting the fish intraperitoneally with pure culture of A.jandaei isolated from diseased fish. Histopathogical studies revealed necrosis hemorrhaging, and other cellular alterations of different tissues of collected organs viz. gill, liver, and kidney of P. hypophthalmus, observed with the diseased conditions