11 research outputs found
Regresija asimetriÄnog tremora gornjih udova nakon transplantacije jetre u bolesnika s hepatalnom encefalopatijom: prikaz sluÄaja
Hepatic encephalopathy (HE) is a brain dysfunction caused by liver failure. Clinically, it can manifests as a wide spectrum of neurological or psychiatric abnormalities. This report presents a case of a 43-year-old male with HE and asymmetric kinetic, postural and resting tremor of upper extremities. Magnetic resonance imaging (MRI) of the brain showed signal abnormalities in numerous areas. The patient underwent liver transplantation and six months after normalization of liver function, tremor as well as brain MRI abnormalities almost completely regressed. This case report presents the asymmetric and reversible kinetic, postural and resting tremor of upper extremities as part of the spectrum of neurological abnormalities in HE.Hepatalna encefalopatija poremeÄaj je funkcije mozga uzrokovan jetrenom insuficijencijom. KliniÄki se može oÄitovati Å”irokim spektrom neuroloÅ”kih i psihijatrijskih poremeÄaja. Ovdje prikazujemo 43-godiÅ”njeg muÅ”karca s hepatalnom encefalopatijom i asimetriÄnim akcijskim, posturalnim i tremorom u mirovanju gornjih udova. Magnetska rezonancija (MR) mozga pokazala je promjene signala u brojnim arejama. Bolesnik je podvrgnut transplantaciji jetre i Å”est mjeseci nakon normalizacije jetrene funkcije tremor i MR promjene mozga gotovo su se potpuno povukle. Ovaj prikaz sluÄaja predoÄuje asimetriÄan i reverzibilan akcijski, posturalni i tremor u mirovanju gornjih udova kao dio spektra neuroloÅ”kih poremeÄaja u hepatalnoj encefalopatiji
Incidencija tumora srediÅ”njega živÄanog sustava u bolesnika hospitaliziranih u KliniÄkom bolniÄkom centru Split od 1. sijeÄnja 2004. do 31. prosinca 2013. godine
The aim was to evaluate the incidence and characteristics of central nervous system tumors in patients hospitalized at the Department of Neurology, Split University Hospital Centre, during a 10-year period. The study included data on 859 patients with the diagnosis of central nervous system (CNS) tumor. Diagnosis was based on the routine CNS neuroimaging methods (computed tomography/magnetic resonance imaging). Access to patient medical records provided demographic and clinical data, continued by collection of data on potential lethal outcome of patients at the Registrarās Office. The study was conducted at the Department of Neurology, Split University Hospital Centre, from January 1, 2004 to December 31, 2013. There were 448 male and 411 female patients. Median age at the diagnosis was 65 (range, 18-95) years. Primary CNS tumors were diagnosed in 527 patients, including 30 primary recurrent tumors, whereas 328 patients had metastatic tumors; in 4 cases, it was impossible to determine whether the tumor was a primary one or metastasis based on CNS neuroimaging. The primary tumors proved to be more common than the metastatic ones (Ļ2-test, p<0.05). Multiple tumor transplants were more common than solitary (211 vs. 117; the conclusion was made at a 95% level of confidence; Ļ2-test, p<0.05). The majority of metastases originated from the lung (bronchus and pleura cancer; 46.41%; Ļ2-test, p<0.05; 95% CI). The most common localization of CNS tumors was supratentorial. Based on the double-logarithmic model, we proved with sta-tistical significance that there was an increase in the incidence of CNS tumors (p=0.001). The most common tumors studied were supratentorially localized meningiomas.Cilj je bio ispitati incidenciju i znaÄajke tumora srediÅ”njega živÄanog sustava (SŽS) u bolesnika hospitaliziranih u Klinici za neurologiju KliniÄkoga bolniÄkog centra Split u desetogodiÅ”njem razdoblju. U razdoblju od 1. sijeÄnja 2004. do 31. prosinca 2013. godine u Klinici za neurologiju je bilo hospitalizirano 859 bolesnika s tumorima SŽS. Dijagnoza se temeljila na nalazima slikovnih dijagnostiÄkih metoda (kompjutorizirana tomografija/magnetska rezonancija mozga). Demografski i kliniÄki podaci su prikupljeni iz povijesti bolesti bolesnika. S ciljem odreÄivanja stope smrtnosti studija je nastavljena i Āprikupljanjem podatka iz MatiÄne knjige umrlih. U promatranom razdoblju ukupno je bilo 448 muÅ”karaca i 411 žena s Ātumorima SŽS. ProsjeÄna dob postavljanja dijagnoze je bila 65 godina. Primarni tumori SŽS su dijagnosticirani u 527 Ābolesnika, ukljuÄivo 30 bolesnika s recidivirajuÄim primarnim tumorima, a 328 bolesnika je imalo metastatske tumore. U 4 bolesnika nije bilo moguÄe odrediti je li se radilo o primarnom tumoru ili metastazi na temelju neuroradioloÅ”kih nalaza. Primarni tumori su bili ÄeÅ”Äi od metastatskih (Ļ2-test, p<0,05). Multiple presadnice su bile ÄeÅ”Äe od solitarnih (211 prema 117, 95% CI; Ļ2-test, p<0,05). VeÄina metastaza je bila podrijetlom iz tumora pluÄa (46,41%; Ļ2-test, p<0,05; 95% CI). NajÄeÅ”Äi su bili supratentorijski lokalizirani tumori SŽS. Primjenom dvostruko-logaritamskog modela pokazali smo da postoji statistiÄki zaÄajan porast incidencije tumora SŽS u ispitivanom razdoblju. Od svih tumora SŽS najÄeÅ”Äi su bili suptratentorijski meningeomi
TENSION-TYPE HEADACHE FROM THE ASPECTS OF PUBLIC HEALTH ISSUES AND TREATMENT POSSIBILITIES
Uvod: Tenzijska glavobolja (TTH) spada u skupinu primarnih glavobolja. Nastanak boli nije posve jasan kao ni patofizioloÅ”ki proces nastanka boli. Glavobolja može biti epizodiÄna (trajanje boli do 15 dana) ili kroniÄnog (trajanje boli 15 ili viÅ”e dana) tipa. Cilj: Cilj ovog rada je procjena javnozdravstvenog problema tenzijske glavobolje kao i moguÄnosti adekvatnog lijeÄenja i profilakse tenzijske glavobolje. Metode: Za ovo ispitivanje koristili smo bazu podataka Pub med uzimajuÄi pojmove; tenzijska glavobolja, prevalencija i lijeÄenje (tension type headache, prevalence, therapy). Rezultati: UÄestalost TTH znaÄajno oscilira u ovisnosti o socioekonomskim uvjetima, a moguÄe i o rasnim razlikama. UÄestalost raste sa životnom dobi. ÄeÅ”Äe se javlja kod žena. LijeÄi se analgeticima i nesteroidnim antireumaticima. Profilaksa kroniÄne TTH provodi se primjenom amitriptilina, mirtazapina, venlafaksina. U sluÄaju potrebe ukljuÄuje se druga linija profilakse koja obuhvaÄa klomipramin, maprotilin i mianserin. Uz to koriste se i nemedikamentne moguÄnosti lijeÄenja kao Å”to su akupunktura, biofeedback metode, kognitivno-bihevioralno lijeÄenje, relaksacijski treninzi. Rasprava: Tenzijska glavobolja je relativno Äest javno-zdravstveni problem u suvremenom svijetu Äiji patofizioloÅ”ki mehanizam nije posve rasvijetljen. Smatra se da je ova glavobolja multifaktorski uvjetovana. Osim epizodiÄne glavobolje znaÄajno veÄi problem je kroniÄna tenzijska glavobolja koja zahtijeva kontinuiranu profilaksu. Nemedikamentne metode profilakse TTH su nedovoljno istražene i zahtijevaju kliniÄko-znanstvenu evaluaciju. ZakljuÄak: U suvremenom svijetu tenzijska glavobolja, posebno kroniÄna TTH, je javnozdravstveni problem koji treba zbrinjavati na adekvatan naÄin. Uz Å”iroku lepezu medikamentne terapije nameÄu se i pomoÄne metode lijeÄenja koje treba dodatno evaluirati.Introduction: Tension-type headache (TTH) belongs to the group of primary headaches. The pain origin is not completely clear, nor is the pathophysiological process of its occurrence. The headache may be of episodic (lasting for up to 15 days) or chronic (lasting for 15 or more days) type. Aim: The aim of the study was to assess public health issues of TTH and the possibilities of its appropriate treatment and prophylaxis. Methods: In this research, we used the PubMed database and the words ātension-type headache, prevalence and therapyā. Results: The TTH prevalence signiļ¬ cantly oscillates depending on socioeconomic conditions and, possibly, race differences. The prevalence increases with age. It is more common in women. It is treated with analgesics and nonsteroidal antirheumatic agents. Chronic TTH prophylaxis includes amitriptyline, mitrazapine and venlafaxine. When necessary, second-line prophylaxis that includes clomipramine, maprotiline and mianserin is administered. Besides these, non-medicamentous treatment methods such as acupuncture, biofeedback, cognitive-behavioral treatment and relaxation trainings are also used. Discussion: In the modern world, TTH is a relatively often public-health issue the pathophysiological mechanism of which has not been clariļ¬ ed yet. This headache is deemed to be of multifactorial cause. Besides episodic headaches, a much greater problem is chronic TTH that requires continuous prophylaxis. The non-medicamentous methods of TTH prophylaxis are insufļ¬ ciently researched and require clinical scientiļ¬ c evaluation. Conclusion: In the modern world, TTH, especially chronic TTH, makes a public-health issue that is to be adequately treated. Besides the wide variety of medicamentous therapies, required are also auxiliary treatment methods that need to be additionally evaluated
TENSION-TYPE HEADACHE FROM THE ASPECTS OF PUBLIC HEALTH ISSUES AND TREATMENT POSSIBILITIES
Uvod: Tenzijska glavobolja (TTH) spada u skupinu primarnih glavobolja. Nastanak boli nije posve jasan kao ni patofizioloÅ”ki proces nastanka boli. Glavobolja može biti epizodiÄna (trajanje boli do 15 dana) ili kroniÄnog (trajanje boli 15 ili viÅ”e dana) tipa. Cilj: Cilj ovog rada je procjena javnozdravstvenog problema tenzijske glavobolje kao i moguÄnosti adekvatnog lijeÄenja i profilakse tenzijske glavobolje. Metode: Za ovo ispitivanje koristili smo bazu podataka Pub med uzimajuÄi pojmove; tenzijska glavobolja, prevalencija i lijeÄenje (tension type headache, prevalence, therapy). Rezultati: UÄestalost TTH znaÄajno oscilira u ovisnosti o socioekonomskim uvjetima, a moguÄe i o rasnim razlikama. UÄestalost raste sa životnom dobi. ÄeÅ”Äe se javlja kod žena. LijeÄi se analgeticima i nesteroidnim antireumaticima. Profilaksa kroniÄne TTH provodi se primjenom amitriptilina, mirtazapina, venlafaksina. U sluÄaju potrebe ukljuÄuje se druga linija profilakse koja obuhvaÄa klomipramin, maprotilin i mianserin. Uz to koriste se i nemedikamentne moguÄnosti lijeÄenja kao Å”to su akupunktura, biofeedback metode, kognitivno-bihevioralno lijeÄenje, relaksacijski treninzi. Rasprava: Tenzijska glavobolja je relativno Äest javno-zdravstveni problem u suvremenom svijetu Äiji patofizioloÅ”ki mehanizam nije posve rasvijetljen. Smatra se da je ova glavobolja multifaktorski uvjetovana. Osim epizodiÄne glavobolje znaÄajno veÄi problem je kroniÄna tenzijska glavobolja koja zahtijeva kontinuiranu profilaksu. Nemedikamentne metode profilakse TTH su nedovoljno istražene i zahtijevaju kliniÄko-znanstvenu evaluaciju. ZakljuÄak: U suvremenom svijetu tenzijska glavobolja, posebno kroniÄna TTH, je javnozdravstveni problem koji treba zbrinjavati na adekvatan naÄin. Uz Å”iroku lepezu medikamentne terapije nameÄu se i pomoÄne metode lijeÄenja koje treba dodatno evaluirati.Introduction: Tension-type headache (TTH) belongs to the group of primary headaches. The pain origin is not completely clear, nor is the pathophysiological process of its occurrence. The headache may be of episodic (lasting for up to 15 days) or chronic (lasting for 15 or more days) type. Aim: The aim of the study was to assess public health issues of TTH and the possibilities of its appropriate treatment and prophylaxis. Methods: In this research, we used the PubMed database and the words ātension-type headache, prevalence and therapyā. Results: The TTH prevalence signiļ¬ cantly oscillates depending on socioeconomic conditions and, possibly, race differences. The prevalence increases with age. It is more common in women. It is treated with analgesics and nonsteroidal antirheumatic agents. Chronic TTH prophylaxis includes amitriptyline, mitrazapine and venlafaxine. When necessary, second-line prophylaxis that includes clomipramine, maprotiline and mianserin is administered. Besides these, non-medicamentous treatment methods such as acupuncture, biofeedback, cognitive-behavioral treatment and relaxation trainings are also used. Discussion: In the modern world, TTH is a relatively often public-health issue the pathophysiological mechanism of which has not been clariļ¬ ed yet. This headache is deemed to be of multifactorial cause. Besides episodic headaches, a much greater problem is chronic TTH that requires continuous prophylaxis. The non-medicamentous methods of TTH prophylaxis are insufļ¬ ciently researched and require clinical scientiļ¬ c evaluation. Conclusion: In the modern world, TTH, especially chronic TTH, makes a public-health issue that is to be adequately treated. Besides the wide variety of medicamentous therapies, required are also auxiliary treatment methods that need to be additionally evaluated
Vrijeme do prijema u bolnicu kod bolesnika s akutnim moždanim udarom - opservacijska studija u Splitsko-Dalmatinskoj županiji, Hrvatska
The objective of this prospective observational study was to determine and document the time elapsed from symptom onset to hospital admission in patients with acute stroke. The study was conducted at Emergency Department, University Department of Neurology, Split University Hospital in Split, Croatia, from October 1, 2004 to December 21, 2004, and included 115 patients with acute stroke. Data on the time of onset of stroke symptoms, brain computed tomography finding and current clinical status were noted. Fifteen patients were excluded from the study because the exact time of symptom onset could not be determined. A standardized interview with patients and/or their relatives was taken to collect the information needed. Ischemic stroke was diagnosed in 82 of 100 patients. Only 13 patients arrived in hospital within 3 hours of stroke symptom onset, and 29 were admitted to hospital more than 24 hours of stroke symptom onset. Sex had no significant effect on arrival time. It was concluded that the majority of patients with acute stroke did not present to emergency department within 3 hours of symptom onset, the current time window for thrombolytic therapy. It seems crucial to identify the factors associated with late presentation to the hospital. Public recognition of stroke symptoms and understanding of the importance of early hospital admission are mandatory for improving the results recorded in this study with time elapsed from symptom onset to hospital admission and eligibility for thrombolytic therapy taken as the main outcome measures. Additional public education is needed to increase awareness of the stroke warning signs.Cilj ove prospektivne opservacijske studije bio je utvrditi i dokumentirati vrijeme proteklo od nastupa simptoma do prijema u bolnicu kod bolesnika s akutnim moždanim udarom. Studija je provedena na Hitnom odjelu Klinike za neurologĀ¬iju, KliniÄke bolnice Split u Splitu od 1. listopada 2004. do 21. prosinca 2004. godine i ukljuÄila je 115 bolesnika s akutnim moždanim udarom. Bilježili su se podatci o vremenu nastupa simptoma moždanog udara, nalazu kompjutorizirane tomografije mozga i aktualnom kliniÄkom statusu. Iz studije je iskljuÄeno 15 bolesnika u kojih se toÄno vrijeme nastupa simptoma nije moglo utvrditi. Proveden je standardizirani razgovor s bolesnicima i/ili njihovom rodbinom kako bi se dobile potrebne informacije. Ishemijski moždani udar je utvrÄen u 82 od 100 bolesnika. Samo je 13 bolesnika stiglo u bolnicu unutar 3 sata od nastupa simptoma akutnog moždanog udara, a 29 ih je u bolnicu primljeno vi.e od 24 sata od nastupa simptoma. Spol nije imao znaÄajnog utjecaja na vrijeme dolaska u bolnicu. Rezultati su pokazali kako veÄina bolesnika s akutnim moždanim udarom nije pristigla na hitni odjel unutar 3 sata od nastupa simptoma, Å”to danas predstavlja vremenĀ¬ski okvir za trombolitiÄnu terapiju. Od kljuÄne je važnosti utvrditi Äimbenike koji su povezani sa zakaÅ”njelim dolaskom u bolnicu. OpÄe prepoznavanje simptoma moždanog udara i shvaÄanje važnosti ranog prijema u bolnicu neophodno je za poboljÅ”anje rezultata dobivenih u ovoj studiji, u kojoj su glavne mjere ishoda bili vrijeme proteklo od nastupa simptoma do prijema u bolnicu i podobnost za trombolitiÄnu terapiju. Potrebna je daljnja izobrazba javnosti kako bi se poveÄala svijest o upozoravajuÄim znacima moždanoga udara
UspjeÅ”no lijeÄenje akutnog diseminiranog encefalomijelitisa (ADEM) pravodobnom primjenom imunoglobulina ā prikaz sluÄaja i pregled literature
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that usually affects children and young adults. It most commonly has a monophasic course, although relapses are reported. Clinical presentation of the disease
includes encephalopathy and multifocal neurological deficits. There are no established reliable criteria for diagnosis of ADEM and sometimes it is difficult to distinguish it from first attack of multiple sclerosis, especially in adults. The diagnosis of ADEM is based on clinical, radiological and laboratory findings. In the treatment of ADEM, high doses of corticosteroids, plasmapheresis and immunoglobulins are used. We report a case of a young adult female patient with ADEM who fully recovered after prompt administration of high dose methylprednisolone and immunoglobulins.Akutni diseminirani encefalomijelitis (ADEM) je upalna demijelinizirajuÄa bolest srediÅ”njega živÄanog sustava koja obiÄno pogaÄa djecu i mlade odrasle osobe. NajÄeÅ”Äe ima monofazni tijek, iako su zabilježeni i relapsi bolesti. KliniÄka prezentacija bolesti ukljuÄuje encefalopatiju i multifokalne neuroloÅ”ke deficite. Pouzdani kriteriji za dijagnozu ADEM-a nisu utvrÄeni i ponekad ga je teÅ”ko razlikovati od prve atake multiple skleroze, osobito kod odraslih. Dijagnoza ADEM-a temelji se na kliniÄkim, radioloÅ”kim i laboratorijskim nalazima. U lijeÄenju ADEM-a primjenjuju se visoke doze kortikosteroida, plazmafereza i imunoglobulini. Prikazujemo sluÄaj mlade odrasle bolesnice kod koje je potpun oporavak uslijedio nakon pravodobne primjene visoke doze metilprednizolona i imunoglobulina
Psychometric Validation of the Croatian Version of the Quality of Life in Epilepsy Inventory (QOLIE-31)
The primary goals of this study were to adapt the Quality of Life in Epilepsy Inventory ā 31 items (QOLIE-31) questionnaire
to the Croatian language and to assess the translated questionnaireās psychometric properties. Translation/
retranslation of the English version of the QOLIE-31 was done, and all steps for cross-cultural adaptation process were
performed properly by an expert committee. Later, QOLIE-31 questionnaires and previously validated Short Form-36
(SF-36) outcome instruments were given to 200 patients with epilepsy. 172 patients (86%) responded to the first set of
questionnaires, and 114 of the first time respondents (66%) returned their second survey. The two measures of reliability
as internal consistency and reproducibility were determined by Cronbach a statistics and intraclass correlation coefficient,
respectively. Concurrent validity was measured by comparing with a SF-36 questionnaire, and measurement was
made using the Pearson correlation coefficient (r). The study demonstrated satisfactory internal consistency with high
Cronbach a values for all of the corresponding domains (seizure worry 0.84, medication effects 0.80, emotional well-being
0.73, energy/fatigue 0.76, cognitive functioning 0.71, social functioning 0.77, overall quality of life 0.65). The intraclass
correlation coefficient for six domains of QOLIE-31 questionnaire demonstrated excellent test/retest reproducibility
(ICC 0.75), and good test/retest reproducibility (ICC 0.71) in one domain (cognitive functioning). Considering concurrent
validity, three domains had excellent correlation (r=0.75ā1), while 11 had good correlation (r=0.50 to 0.75), and 3
had moderate correlation (r=0.25ā0.50). This study demonstrated that, if measures are to be used across cultures, the
items must not only be translated well linguistically but also must be culturally adapted to maintain the content validity
of the instrument at a conceptual level across different cultures. Croatian version of QOLIE-31 will be a valuable contribution
to outcome measurement in epilepsy patients, particularly in the context of treatment trials, but als in a wider research
context
Kompletni atrioventrikulski blok i asistolija tijekom epileptiÄkog napadaja: prikaz sluÄaja
Cardiac arrhythmias during or after epileptic seizures are one of the possible pathomechanisms of sudden unexpected death in epilepsy. These arrhythmogenic epilepsies are most commonly associated with sinus tachycardia, but atrioventricular block and asystole can also be seen. Although a rare occurrence, these arrhythmias can lead to significant morbidity and mortality, but also can be potentially preventable with pacemaker implantation. Here we describe a patient with recurrent epileptic seizures, diagnosed with ictal third-degree atrioventricular block and asystole during seizure, which required a permanent cardiac pacemaker.SrÄane aritmije tijekom ili nakon epileptiÄkih napadaja jedan su od moguÄih patomehanizama neoÄekivane smrti u bolesnika s epilepsijom. Ove aritmogene epilepsije najÄeÅ”Äe su povezane sa sinus tahikardijom, ali se mogu uoÄiti i atrioventrikulski blok i asistolija. Iako se rijetko pojavljuju, ove aritmije mogu dovesti do znaÄajnog pobola i smrtnosti, ali se takoÄer
mogu prevenirati ugradnjom srÄanog stimulatora. Ovdje opisujemo bolesnika s ponavljajuÄim epileptiÄkim napadajima i dijagnosticiranim atrioventrikulskim blokom treÄeg stupnja i asistolijom tijekom napadaja kojemu je bilo potrebno ugraditi trajni srÄani stimulator
Psychometric Validation of the Croatian Version of the Quality of Life in Epilepsy Inventory (QOLIE-31)
The primary goals of this study were to adapt the Quality of Life in Epilepsy Inventory ā 31 items (QOLIE-31) questionnaire
to the Croatian language and to assess the translated questionnaireās psychometric properties. Translation/
retranslation of the English version of the QOLIE-31 was done, and all steps for cross-cultural adaptation process were
performed properly by an expert committee. Later, QOLIE-31 questionnaires and previously validated Short Form-36
(SF-36) outcome instruments were given to 200 patients with epilepsy. 172 patients (86%) responded to the first set of
questionnaires, and 114 of the first time respondents (66%) returned their second survey. The two measures of reliability
as internal consistency and reproducibility were determined by Cronbach a statistics and intraclass correlation coefficient,
respectively. Concurrent validity was measured by comparing with a SF-36 questionnaire, and measurement was
made using the Pearson correlation coefficient (r). The study demonstrated satisfactory internal consistency with high
Cronbach a values for all of the corresponding domains (seizure worry 0.84, medication effects 0.80, emotional well-being
0.73, energy/fatigue 0.76, cognitive functioning 0.71, social functioning 0.77, overall quality of life 0.65). The intraclass
correlation coefficient for six domains of QOLIE-31 questionnaire demonstrated excellent test/retest reproducibility
(ICC 0.75), and good test/retest reproducibility (ICC 0.71) in one domain (cognitive functioning). Considering concurrent
validity, three domains had excellent correlation (r=0.75ā1), while 11 had good correlation (r=0.50 to 0.75), and 3
had moderate correlation (r=0.25ā0.50). This study demonstrated that, if measures are to be used across cultures, the
items must not only be translated well linguistically but also must be culturally adapted to maintain the content validity
of the instrument at a conceptual level across different cultures. Croatian version of QOLIE-31 will be a valuable contribution
to outcome measurement in epilepsy patients, particularly in the context of treatment trials, but als in a wider research
context
Incidence of Central Nervous System Tumors in Patients Hospitalized at Split University Hospital Centre During a Ten-Year Period (January 1, 2004 ā December 31, 2013)
The aim was to evaluate the incidence and characteristics of central nervous system tumors in patients hospitalized at the Department of Neurology, Split University Hospital Centre, during a 10-year period. The study included data on 859 patients with the diagnosis of central nervous system (CNS) tumor. Diagnosis was based on the routine CNS neuroimaging methods (computed tomography/magnetic resonance imaging). Access to patient medical records provided demographic and clinical data, continued by collection of data on potential lethal outcome of patients at the Registrarās Office. The study was conducted at the Department of Neurology, Split University Hospital Centre, from January 1, 2004 to December 31, 2013. There were 448 male and 411 female patients. Median age at the diagnosis was 65 (range, 18-95) years. Primary CNS tumors were diagnosed in 527 patients, including 30 primary recurrent tumors, whereas 328 patients had metastatic tumors; in 4 cases, it was impossible to determine whether the tumor was a primary one or metastasis based on CNS neuroimaging. The primary tumors proved to be more common than the metastatic ones (Ļ2-test, p<0.05). Multiple tumor transplants were more common than solitary (211 vs. 117; the conclusion was made at a 95% level of confidence; Ļ2-test, p<0.05). The majority of metastases originated from the lung (bronchus and pleura cancer; 46.41%; Ļ2-test, p<0.05; 95% CI). The most common localization of CNS tumors was supratentorial. Based on the double-logarithmic model, we proved with sta-tistical significance that there was an increase in the incidence of CNS tumors (p=0.001). The most common tumors studied were supratentorially localized meningiomas