Synthesis and pharmacological activity of 1-phenyl-2-oxa-5-azabicyclo[4.4.0]decane derivatives

Title compds. I (Z = O, H2; R = H, Me) and II were prepd., and they showed central nervous system stimulant and anticonvulsant activity. Thus, a 2-aminocyclohexanol deriv. was treated with ClCH2COCl and NaOH to give amide III, and III and KOCMe3 in C6H6 were kept at room temp. to give I (Z = O, R = H)