2,673 research outputs found
Effects of a Disulfide Crosslink (XL) on the Trypsin Cleavage Pattern of Rabbit Cardiac Tropomyosin (TM)
Why Dominant Governing Parties Are Cross-Nationally Influential
Previous research suggests that political parties learn from and emulate the successful election strategies of governing parties in other countries. But what explains variation in the degree of influence that governing parties have on their foreign counterparts? We argue that “clarity of responsibility” within government, or the concentration of executive responsibility in the hands of a dominant governing party, allows parties to learn from the most obviously electorally successful incumbents. It therefore enhances the cross-national diffusion of party programs. To test this expectation, we analyze parties’ policy positions in 26 established democracies since 1977. Our results indicate that parties disproportionately learn from and emulate dominant, highclarity foreign incumbents. This finding contributes to a better understanding of the political consequences of “government clarity” and sheds new light on the heuristics that engender party policy diffusion by demonstrating that the most visible foreign incumbents, whose platforms have yielded concentrated power in office, influence party politics “at home.
Orientational order on curved surfaces - the high temperature region
We study orientational order, subject to thermal fluctuations, on a fixed
curved surface. We derive, in particular, the average density of zeros of
Gaussian distributed vector fields on a closed Riemannian manifold. Results are
compared with the density of disclination charges obtained from a Coulomb gas
model. Our model describes the disordered state of two dimensional objects with
orientational degrees of freedom, such as vector ordering in Langmuir
monolayers and lipid bilayers above the hexatic to fluid transition.Comment: final version, 13 Pages, 2 figures, uses iopart.cl
Globalisation and the ethics of transnational biobank networks
Biobanks are increasingly being linked together into global networks in order to maximise their capacity to identify causes of and treatments for disease. While there is great optimism about the potential of these biobank networks to contribute to personalised and data-driven medicine, there are also ethical concerns about, among other things, risks to personal privacy and exploitation of vulnerable populations. Concepts drawn from theories of globalisation can assist with the characterisation of the ethical implications of biobank networking across borders, which can, in turn, inform more ethically sophisticated responses. Using the China Kadoorie Biobank as a case study, we show how distinguishing between the subnational, transnational, supranational and extranational spheres of operation and influence can help researchers, institutions and regulators to understand and manage the ethical issues raised by the globalisation of biobanking.National Health and Medical Research Council (Australia
Psychological interventions in asthma
Asthma is a multifactorial chronic respiratory disease characterised by recurrent episodes of airway obstruction. The current management of asthma focuses principally on pharmacological treatments, which have a strong evidence base underlying their use. However, in clinical practice, poor symptom control remains a common problem for patients with asthma. Living with asthma has been linked with psychological co-morbidity including anxiety, depression, panic attacks and behavioural factors such as poor adherence and suboptimal self-management. Psychological disorders have a higher-than-expected prevalence in patients with difficult-to-control asthma. As psychological considerations play an important role in the management of people with asthma, it is not surprising that many psychological therapies have been applied in the management of asthma. There are case reports which support their use as an adjunct to pharmacological therapy in selected individuals, and in some clinical trials, benefit is demonstrated, but the evidence is not consistent. When findings are quantitatively synthesised in meta-analyses, no firm conclusions are able to be drawn and no guidelines recommend psychological interventions. These inconsistencies in findings may in part be due to poor study design, the combining of results of studies using different interventions and the diversity of ways patient benefit is assessed. Despite this weak evidence base, the rationale for psychological therapies is plausible, and this therapeutic modality is appealing to both patients and their clinicians as an adjunct to conventional pharmacological treatments. What are urgently required are rigorous evaluations of psychological therapies in asthma, on a par to the quality of pharmaceutical trials. From this evidence base, we can then determine which interventions are beneficial for our patients with asthma management and more specifically which psychological therapy is best suited for each patient
Quantum critical phenomena of long-range interacting bosons in a time-dependent random potential
We study the superfluid-insulator transition of a particle-hole symmetric
system of long-range interacting bosons in a time-dependent random potential in
two dimensions, using the momentum-shell renormalization-group method. We find
a new stable fixed point with non-zero values of the parameters representing
the short- and long-range interactions and disorder when the interaction is
asymptotically logarithmic. This is contrasted to the non-random case with a
logarithmic interaction, where the transition is argued to be first-order, and
to the Coulomb interaction case, where either a first-order transition or
an XY-like transition is possible depending on the parameters. We propose that
our model may be relevant in studying the vortex liquid-vortex glass transition
of interacting vortex lines in point-disordered type-II superconductors.Comment: 10 pages, 3 figure
Variational theory of flux-line liquids
We formulate a variational (Hartree like) description of flux line liquids
which improves on the theory we developed in an earlier paper [A.M. Ettouhami,
Phys. Rev. B 65, 134504 (2002)]. We derive, in particular, how the massive term
confining the fluctuations of flux lines varies with temperature and show that
this term vanishes at high enough temperatures where the vortices behave as
freely fluctuating elastic lines.Comment: 10 pages, 1 postscript figur
- …